Name: Ac-DEVD-AMC *CAS 169332-61-0*
Brand: AAT Bioquest
SKU: 13402
Price: 118 USD
Availability: InStock

Ac-DEVD-AMC

CAS 169332-61-0

Ac-DEVD-AMC is a fluorogenic substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.

Protocol

SDS

Catalog	Size	Price	Quantity
13402	5 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Ac-DEVD-AMC *CAS 169332-61-0* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	148.008 µL	740.039 µL	1.48 mL	7.4 mL	14.801 mL
5 mM	29.602 µL	148.008 µL	296.016 µL	1.48 mL	2.96 mL
10 mM	14.801 µL	74.004 µL	148.008 µL	740.039 µL	1.48 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	675.64 g/mol	=	mL	x	mM	=	mmol

Citations

View all 6 citations: Citation Explorer

Eicosapentaenoic Acid Suppresses Tumor Growth and Enhances Chemosensitivity via AKT/mTOR Signaling in Uterine Serous Carcinoma

Authors:

Zhang, Haomeng and Kong, Weimin and Shen, Xiaochang and Chen, Shuning and Boyles, Glenn and Vranes, Chelsey and Singleton, Miller and Diggs, Alexandra and Zhou, Chunxiao and Bae-Jump, Victoria L

Journal:

Cancers (2026): 1120

Assessment of caspase activity in post mortem muscle as a way to explain characteristics of DFD beef

Authors:

Fuente-Garc{\'\i}a, Claudia and Aldai, Noelia and Sentandreu, Enrique and Oliv{\'a}n, Mamen and Franco, Daniel and Garc{\'\i}a-Torres, Susana and Sentandreu, Miguel {\'A}ngel

Journal:

Journal of Food Composition and Analysis (2022): 104599

Ipatasertib, an oral AKT inhibitor, inhibits cell proliferation and migration, and induces apoptosis in serous endometrial cancer

Authors:

Buckingham, Lindsey and Hao, Tianran and O’Donnell, Jillian and Zhao, Ziyi and Zhang, Xin and Fan, Yali and Sun, Wenchuan and Zhang, Yingao and Suo, Hongyan and Secord, Angeles Alvarez and others,

Journal:

American Journal of Cancer Research (2022): 2850

ONC206, an imipridone derivative, induces cell death through activation of the integrated stress response in serous endometrial cancer in vitro

Authors:

Zhang, Yingao and Huang, Yu and Yin, Yajie and Fan, Yali and Sun, Wenchuan and Zhao, Xiaoling and Tucker, Katherine and Staley, Allison and Paraghamian, Sarah and Hawkins, Gabrielle and others,

Journal:

Frontiers in Oncology (2020): 577141

Overexpression of ILK promotes temozolomide resistance in glioma cells

Authors:

Liang, Feng and Wang, Bing and Bao, Long and Zhao, Yin-Sheng and Zhang, Shi-Min and Zhang, Shu-Qin

Journal:

Molecular medicine reports (2017): 1297--1304

References

View all 67 references: Citation Explorer

Quantitative measurement of caspase-3 activity in a living starfish egg

Authors:

Sakaue M, Motoyama Y, Yamamoto K, Shiba T, Teshima T, Chiba K.

Journal:

Biochem Biophys Res Commun (2006): 878

Serofendic acid, a neuroprotective substance derived from fetal calf serum, inhibits mitochondrial membrane depolarization and caspase-3 activation

Authors:

Kume T, Taguchi R, Katsuki H, Akao M, Sugimoto H, Kaneko S, Akaike A.

Journal:

Eur J Pharmacol (2006): 69

Multiparameter measurement of caspase 3 activation and apoptotic cell death in NT2 neuronal precursor cells using high-content analysis

Authors:

Fennell M, Chan H, Wood A.

Journal:

J Biomol Screen (2006): 296

Asymmetric dimethylarginine induces apoptosis via p38 MAPK/caspase-3-dependent signaling pathway in endothelial cells

Authors:

Jiang DJ, Jia SJ, Dai Z, Li YJ.

Journal:

J Mol Cell Cardiol (2006): 529

Diallyl Trisulfide Induces Apoptosis of Human Gastric Cancer Cell Line MGC803 Through Caspase-3 Pathway.

Authors:

Xiao XL, Peng J, Su Q, Xiang SL, Tang GH, Huang YS, Zhou XT.

Journal:

Ai Zheng (2006): 1247

Physical properties

Molecular weight	675.64
Solvent	DMSO

Spectral properties

Excitation (nm)	341
Emission (nm)	441

Usage and storage

Intended use	Research Use Only (RUO)
Storage	Freeze (< -15 °C); Minimize light exposure
CAS	169332-61-0

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Page updated on July 17, 2026