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Ac-DEVD-CHO *CAS 169332-60-9*

Chemical structure for Ac-DEVD-CHO *CAS 169332-60-9*
Chemical structure for Ac-DEVD-CHO *CAS 169332-60-9*
Ordering information
Price ()
Catalog Number13403
Unit Size
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Telephone1-408-733-1055
Fax1-408-733-1304
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ShippingStandard overnight for United States, inquire for international
Physical properties
Molecular weight502.47
SolventDMSO
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
UNSPSC12352200

OverviewpdfSDSpdfProtocol


CAS
169332-60-9
Molecular weight
502.47
Ac-DEVD-CHO is a reversible inhibitor of IL-1? converting enzyme (ICE); inhibits poly(ADP-ribose) polymerase cleavage by apopain (caspase 3).

Calculators


Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Ac-DEVD-CHO *CAS 169332-60-9* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM199.017 µL995.084 µL1.99 mL9.951 mL19.902 mL
5 mM39.803 µL199.017 µL398.034 µL1.99 mL3.98 mL
10 mM19.902 µL99.508 µL199.017 µL995.084 µL1.99 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

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Citations


View all 3 citations: Citation Explorer
Ferrous-Supply-Regeneration Nanoengineering for Cancer Cell Specific Ferroptosis in Combination with Imaging-Guided Photodynamic Therapy
Authors: Liu, Tao and Liu, Wenlong and Zhang, Mingkang and Yu, Wuyang and Gao, Fan and Li, Chuxin and Wang, Shi-Bo and Feng, Jun and Zhang, Xian-Zheng
Journal: ACS nano (2018)
pH-Assisted surface functionalization of selenium nanoparticles with curcumin to achieve enhanced cancer chemopreventive activity
Authors: Yu, Shaoxuan and Wang, Yanru and Zhang, Wentao and Zhang, Yuhuan and Zhu, Wenxin and Liu, Yingnan and Zhang, Daohong and Wang, Jianlong
Journal: RSC Advances (2016): 72213--72223
Synthesis and evaluation of N-acyl-substituted 1, 2-benzisothiazol-3-one derivatives as caspase-3 inhibitors
Authors: Li, Zhenghui and Pan, Yang and Zhong, Weilong and Zhu, Yunpeng and Zhao, Yongle and Li, Lixin and Liu, Wei and Zhou, Honggang and Yang, Cheng
Journal: Bioorganic \& Medicinal Chemistry (2014): 6735--6745

References


View all 67 references: Citation Explorer
In vivo and in vitro sensitization of leukemic cells to adriamycin-induced apoptosis by pentoxifylline. Involvement of caspase cascades and IkappaBalpha phosphorylation
Authors: Lerma-Diaz JM, Hern and ez-Flores G, Dominguez-Rodriguez JR, Ortiz-Lazareno PC, Gomez-Contreras P, Cervantes-Munguia R, Scott-Algara D, Aguilar-Lemarroy A, Jave-Suarez LF, Bravo-Cuellar A.
Journal: Immunol Lett (2006): 149
Measurement of two caspase activities simultaneously in living cells by a novel dual FRET fluorescent indicator probe
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Journal: Cytometry A (2006): 477
Quantitative measurement of caspase-3 activity in a living starfish egg
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Journal: Biochem Biophys Res Commun (2006): 878
Photoreceptor cell apoptosis induced by the 2-nitroimidazole radiosensitizer, CI-1010, is mediated by p53-linked activation of caspase-3
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Diallyl Trisulfide Induces Apoptosis of Human Gastric Cancer Cell Line MGC803 Through Caspase-3 Pathway.
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Journal: Ai Zheng (2006): 1247
Asymmetric dimethylarginine induces apoptosis via p38 MAPK/caspase-3-dependent signaling pathway in endothelial cells
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Journal: J Mol Cell Cardiol (2006): 529
Multiparameter measurement of caspase 3 activation and apoptotic cell death in NT2 neuronal precursor cells using high-content analysis
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Journal: J Biomol Screen (2006): 296
Serofendic acid, a neuroprotective substance derived from fetal calf serum, inhibits mitochondrial membrane depolarization and caspase-3 activation
Authors: Kume T, Taguchi R, Katsuki H, Akao M, Sugimoto H, Kaneko S, Akaike A.
Journal: Eur J Pharmacol (2006): 69
Homogeneous, bioluminescent protease assays: caspase-3 as a model
Authors: O'Brien MA, Daily WJ, Hesselberth PE, Moravec RA, Scurria MA, Klaubert DH, Bulleit RF, Wood KV.
Journal: J Biomol Screen (2005): 137
Caspase-3 activation and induction of PARP cleavage by cyclic dipeptide cyclo(Phe-Pro) in HT-29 cells
Authors: Brauns SC, Dealtry G, Milne P, Naude R, Van de Venter M.
Journal: Anticancer Res (2005): 4197