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Ac-DEVD-CHO *CAS 169332-60-9*

Ac-DEVD-CHO is a reversible inhibitor of IL-1? converting enzyme (ICE); inhibits poly(ADP-ribose) polymerase cleavage by apopain (caspase 3).

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Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Ac-DEVD-CHO *CAS 169332-60-9* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM199.017 µL995.084 µL1.99 mL9.951 mL19.902 mL
5 mM39.803 µL199.017 µL398.034 µL1.99 mL3.98 mL
10 mM19.902 µL99.508 µL199.017 µL995.084 µL1.99 mL

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Citations

View all 3 citations: Citation Explorer
Ferrous-Supply-Regeneration Nanoengineering for Cancer Cell Specific Ferroptosis in Combination with Imaging-Guided Photodynamic Therapy
Authors: Liu, Tao and Liu, Wenlong and Zhang, Mingkang and Yu, Wuyang and Gao, Fan and Li, Chuxin and Wang, Shi-Bo and Feng, Jun and Zhang, Xian-Zheng
Journal: ACS nano (2018)
pH-Assisted surface functionalization of selenium nanoparticles with curcumin to achieve enhanced cancer chemopreventive activity
Authors: Yu, Shaoxuan and Wang, Yanru and Zhang, Wentao and Zhang, Yuhuan and Zhu, Wenxin and Liu, Yingnan and Zhang, Daohong and Wang, Jianlong
Journal: RSC Advances (2016): 72213--72223
Synthesis and evaluation of N-acyl-substituted 1, 2-benzisothiazol-3-one derivatives as caspase-3 inhibitors
Authors: Li, Zhenghui and Pan, Yang and Zhong, Weilong and Zhu, Yunpeng and Zhao, Yongle and Li, Lixin and Liu, Wei and Zhou, Honggang and Yang, Cheng
Journal: Bioorganic \& Medicinal Chemistry (2014): 6735--6745

References

View all 67 references: Citation Explorer
In vivo and in vitro sensitization of leukemic cells to adriamycin-induced apoptosis by pentoxifylline. Involvement of caspase cascades and IkappaBalpha phosphorylation
Authors: Lerma-Diaz JM, Hern and ez-Flores G, Dominguez-Rodriguez JR, Ortiz-Lazareno PC, Gomez-Contreras P, Cervantes-Munguia R, Scott-Algara D, Aguilar-Lemarroy A, Jave-Suarez LF, Bravo-Cuellar A.
Journal: Immunol Lett (2006): 149
Measurement of two caspase activities simultaneously in living cells by a novel dual FRET fluorescent indicator probe
Authors: Wu X, Simone J, Hewgill D, Siegel R, Lipsky PE, He L.
Journal: Cytometry A (2006): 477
Quantitative measurement of caspase-3 activity in a living starfish egg
Authors: Sakaue M, Motoyama Y, Yamamoto K, Shiba T, Teshima T, Chiba K.
Journal: Biochem Biophys Res Commun (2006): 878
Photoreceptor cell apoptosis induced by the 2-nitroimidazole radiosensitizer, CI-1010, is mediated by p53-linked activation of caspase-3
Authors: Miller TJ, Schneider RJ, Miller JA, Martin BP, Al-Ubaidi MR, Agarwal N, Dethloff LA, Philbert MA.
Journal: Neurotoxicology (2006): 44
Diallyl Trisulfide Induces Apoptosis of Human Gastric Cancer Cell Line MGC803 Through Caspase-3 Pathway.
Authors: Xiao XL, Peng J, Su Q, Xiang SL, Tang GH, Huang YS, Zhou XT.
Journal: Ai Zheng (2006): 1247
Page updated on December 6, 2024

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Physical properties

Molecular weight

502.47

Solvent

DMSO

Storage, safety and handling

H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22

Storage

Freeze (< -15 °C); Minimize light exposure
UNSPSC12352200

CAS

169332-60-9
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