Acetic Acid N-Succinimidyl Ester

Acetic Acid N-Succinimidyl Ester is a convenient reagent for blocking amino groups of biological molecules. It has an extremely small size, thus minimizing the negative effect of the molecules to be modified. It readily reacts with biological molecules (such as antibodies, peptides, amino-modified oligos) under mild conditions with optimized pH from 7.5 to 9.0.

Datasheet

SDS

COA

Catalog	Size	Price	Quantity
4508	100 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Acetic Acid N-Succinimidyl Ester to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	636.416 µL	3.182 mL	6.364 mL	31.821 mL	63.642 mL
5 mM	127.283 µL	636.416 µL	1.273 mL	6.364 mL	12.728 mL
10 mM	63.642 µL	318.208 µL	636.416 µL	3.182 mL	6.364 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	157.13 g/mol	=	mL	x	mM	=	mmol

References

View all 50 references: Citation Explorer

Small RNA SmsR1 modulates acidogenicity and cariogenic virulence by affecting protein acetylation in Streptococcus mutans.

Authors:

Li, Jing and Ma, Qizhao and Huang, Jun and Liu, Yaqi and Zhou, Jing and Yu, Shuxing and Zhang, Qiong and Lin, Yongwang and Wang, Lingyun and Zou, Jing and Li, Yuqing

Journal:

PLoS pathogens (2024): e1012147

The Protein Acetylation after Traumatic Spinal Cord Injury: Mechanisms and Therapeutic Opportunities.

Authors:

Li, Hong-Wei and Zhang, Hai-Hong

Journal:

International journal of medical sciences (2024): 725-731

Sense or nonsense? The role of protein acetylation in cyanobacterial photosynthesis and growth.

Authors:

Yokoyama, Ryo

Journal:

Plant physiology (2024): 595-597

Serine synthesis sustains macrophage IL-1β production via NAD+-dependent protein acetylation.

Authors:

Wang, Chuanlong and Chen, Qingyi and Chen, Siyuan and Fan, Lijuan and Gan, Zhending and Zhao, Muyang and Shi, Lexuan and Bin, Peng and Yang, Guan and Zhou, Xihong and Ren, Wenkai

Journal:

Molecular cell (2024): 744-759.e6

Quantifying Protein Acetylation in Diabetic Nephropathy from Formalin-Fixed Paraffin-Embedded Tissue.

Authors:

Schwab, Stefanie K and Harris, Peter S and Michel, Cole and McGinnis, Courtney D and Nahomi, Rooban B and Assiri, Mohammed A and Reisdorph, Richard and Henriksen, Kammi and Orlicky, David J and Levi, Moshe and Rosenberg, Avi and Nagaraj, Ram H and Fritz, Kristofer S

Journal:

Proteomics. Clinical applications (2024): e202400018

Physical properties

Molecular weight	157.13
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
CAS	14464-29-0

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Page updated on May 6, 2026