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Acridinium Alkyne
Acridinium is a univalent radical derived from acridine. Acridinium alkynes are synthetic molecules known for their strong chemiluminescence, commonly used to label azides on peptides, antibodies, and other biomolecules through copper-catalyzed click reactions. The chemiluminescence of acridinium maleimides is triggered by exposure to an alkaline hydrogen peroxide solution, facilitating their use in sensitive detection methodologies within immunoassays and various biological assays. For accurate signal detection in a chemiluminescence analyzer, a trigger solution containing (A) 0.1% H₂O₂ and 0.1 M HNO₃, and (B) 0.25 M NaOH and 2% Triton X-100 is recommended.
References
View all 50 references: Citation Explorer
Acridinium-Based Chemiluminescent Receptor-Ligand Binding Assay for Protein/Peptide Hormones.
Authors: Daubermann, André Guilherme and Dressano, Keini and de Oliveira Ceciliato, Paulo Henrique and Moura, Daniel S
Journal: Methods in molecular biology (Clifton, N.J.) (2024): 253-263
Authors: Daubermann, André Guilherme and Dressano, Keini and de Oliveira Ceciliato, Paulo Henrique and Moura, Daniel S
Journal: Methods in molecular biology (Clifton, N.J.) (2024): 253-263
Novel Competitive Chemiluminescence DNA Assay Based on Fe3O4@SiO2@Au-Functionalized Magnetic Nanoparticles for Sensitive Detection of p53 Tumor Suppressor Gene.
Authors: Wang, Linyu and Yao, Manwen and Fang, Xiangyi and Yao, Xi
Journal: Applied biochemistry and biotechnology (2019): 152-162
Authors: Wang, Linyu and Yao, Manwen and Fang, Xiangyi and Yao, Xi
Journal: Applied biochemistry and biotechnology (2019): 152-162
Analytical characterization of the Siemens Dimension EXL high-sensitivity cardiac troponin I assay.
Authors: Kavsak, Peter A and MacCuish, Jackie and Boreyko, Jill and Roy, Chantele and Lamers, Shana and Clark, Lorna
Journal: Clinical biochemistry (2019): 52-56
Authors: Kavsak, Peter A and MacCuish, Jackie and Boreyko, Jill and Roy, Chantele and Lamers, Shana and Clark, Lorna
Journal: Clinical biochemistry (2019): 52-56
Chemiluminescent Receptor Binding Assay for Ciguatoxins and Brevetoxins Using Acridinium Brevetoxin-B2.
Authors: Murata, Kazuya and Yasumoto, Takeshi
Journal: Toxins (2019)
Authors: Murata, Kazuya and Yasumoto, Takeshi
Journal: Toxins (2019)
Assay for galactose-deficient IgA1 enables mechanistic studies with primary cells from IgA nephropathy patients.
Authors: Reily, Colin and Rizk, Dana V and Julian, Bruce A and Novak, Jan
Journal: BioTechniques (2018): 71-77
Authors: Reily, Colin and Rizk, Dana V and Julian, Bruce A and Novak, Jan
Journal: BioTechniques (2018): 71-77
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