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Acridinium Azide
Acridinium is a univalent radical derived from acridine. Acridinium azides are synthetic molecules known for their strong chemiluminescence, commonly used to label terminal alkynes on peptides, antibodies, and other biomolecules through copper-catalyzed click reactions. The chemiluminescence of acridinium maleimides is triggered by exposure to an alkaline hydrogen peroxide solution, facilitating their use in sensitive detection methodologies within immunoassays and various biological assays. For accurate signal detection in a chemiluminescence analyzer, a trigger solution containing (A) 0.1% H₂O₂ and 0.1 M HNO₃, and (B) 0.25 M NaOH and 2% Triton X-100 is recommended.
References
View all 50 references: Citation Explorer
Synthesis of 9-(substituted phenoxycarbonyl)-10-methylacridinium trifluoromethanesulfonates: Effects of the leaving group on chemiluminescent properties.
Authors: Smith, Keith and Holland, Andy M and Woodhead, J Stuart and El-Hiti, Gamal A
Journal: Luminescence : the journal of biological and chemical luminescence (2024): e4794
Authors: Smith, Keith and Holland, Andy M and Woodhead, J Stuart and El-Hiti, Gamal A
Journal: Luminescence : the journal of biological and chemical luminescence (2024): e4794
Development of a rapid and ultrasensitive magnetic chemiluminescence immunoassay for the detection of adiponectin and its clinical application.
Authors: Li, Jiexia and Fan, Zhuqiao and Chen, Hanqi and Maria Da Costa, Ernestina and Zhou, Xiaomian and Yu, Nan
Journal: Journal of pharmaceutical and biomedical analysis (2024): 115961
Authors: Li, Jiexia and Fan, Zhuqiao and Chen, Hanqi and Maria Da Costa, Ernestina and Zhou, Xiaomian and Yu, Nan
Journal: Journal of pharmaceutical and biomedical analysis (2024): 115961
Acridinium-Based Chemiluminescent Receptor-Ligand Binding Assay for Protein/Peptide Hormones.
Authors: Daubermann, André Guilherme and Dressano, Keini and de Oliveira Ceciliato, Paulo Henrique and Moura, Daniel S
Journal: Methods in molecular biology (Clifton, N.J.) (2024): 253-263
Authors: Daubermann, André Guilherme and Dressano, Keini and de Oliveira Ceciliato, Paulo Henrique and Moura, Daniel S
Journal: Methods in molecular biology (Clifton, N.J.) (2024): 253-263
Synthesis, structure elucidation, and chemiluminescent activity of new 9-substituted 10-(ω-(succinimidyloxycarbonyl)alkyl)acridinium esters.
Authors: Smith, Keith and Mu, Xiaojing and Li, Zhaoqiang and Holland, Andy M and Woodhead, J Stuart and El-Hiti, Gamal A
Journal: Luminescence : the journal of biological and chemical luminescence (2023): 487-496
Authors: Smith, Keith and Mu, Xiaojing and Li, Zhaoqiang and Holland, Andy M and Woodhead, J Stuart and El-Hiti, Gamal A
Journal: Luminescence : the journal of biological and chemical luminescence (2023): 487-496
Synthesis and chemiluminescent characteristics of two new acridinium esters.
Authors: Smith, Keith and Mu, Xiaojing and Li, Zhaoqiang and Woodhead, J Stuart and El-Hiti, Gamal A
Journal: Luminescence : the journal of biological and chemical luminescence (2023): 1857-1863
Authors: Smith, Keith and Mu, Xiaojing and Li, Zhaoqiang and Woodhead, J Stuart and El-Hiti, Gamal A
Journal: Luminescence : the journal of biological and chemical luminescence (2023): 1857-1863
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