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Actinomycin D
Actinomycin is a polypeptide antibiotic isolated from soil bacteria of the genus Streptomyces. It binds to DNA duplexes, thereby interfering with the action of enzymes engaged in replication and transcription. Actinomycin D is one of the old chemotherapy drugs which have been used in therapy for many years.
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Common stock solution preparation
Table 1. Volume of DMSO needed to reconstitute specific mass of Actinomycin D to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 79.655 µL | 398.273 µL | 796.546 µL | 3.983 mL | 7.965 mL |
| 5 mM | 15.931 µL | 79.655 µL | 159.309 µL | 796.546 µL | 1.593 mL |
| 10 mM | 7.965 µL | 39.827 µL | 79.655 µL | 398.273 µL | 796.546 µL |
Molarity calculator
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Citations
View all 16 citations: Citation Explorer
N6-methyladenosine-modified circ\_0000517 promotes non-small cell lung cancer metastasis via miR-1233-3p/CDH6 axis
Authors: Lin, Weixian and Huang, Lifang and Ou, Zhu’an and Xuan, Yiwen and Zhu, Daoqi and Zhang, Qipeng and Xu, Enwu
Journal: Journal of Molecular Histology (2025): 1--13
Authors: Lin, Weixian and Huang, Lifang and Ou, Zhu’an and Xuan, Yiwen and Zhu, Daoqi and Zhang, Qipeng and Xu, Enwu
Journal: Journal of Molecular Histology (2025): 1--13
hsa\_circ\_0008305 facilitates the malignant progression of hepatocellular carcinoma by regulating AKR1C3 expression and sponging miR-379-5p
Authors: Huang, Shenglan and Liu, Kan and Xu, Yongkan and Wang, Hua and Fu, Shumin and Wu, Jianbing
Journal: Scientific Reports (2025): 1309
Authors: Huang, Shenglan and Liu, Kan and Xu, Yongkan and Wang, Hua and Fu, Shumin and Wu, Jianbing
Journal: Scientific Reports (2025): 1309
Hypoxia-driven M2-polarized macrophages facilitate the epithelial-mesenchymal transition of glioblastoma via extracellular vesicles
Authors: Liu, Liang and Wang, Ran and Alifu, Aogesi and Xiao, Yong and Liu, Yong and Qian, Chunfa and Zhao, Mengjie and Tang, Xianglong and Xie, Yandong and Shi, Yan and others,
Journal: Theranostics (2024): 6392
Authors: Liu, Liang and Wang, Ran and Alifu, Aogesi and Xiao, Yong and Liu, Yong and Qian, Chunfa and Zhao, Mengjie and Tang, Xianglong and Xie, Yandong and Shi, Yan and others,
Journal: Theranostics (2024): 6392
METTL14 inhibits the malignant processes of gastric cancer cells by promoting N6-methyladenosine (m6A) methylation of TAF10
Authors: Zhao, Xin and Lu, Jingfen and Wu, Weimin and Li, Jiahui
Journal: Heliyon (2024)
Authors: Zhao, Xin and Lu, Jingfen and Wu, Weimin and Li, Jiahui
Journal: Heliyon (2024)
Circ\_0044235 regulates the development of osteoarthritis by the modulation of miR-375/PIK3R3 axis
Authors: Qian, Wenjie and Mei, Kai and Zhu, Lei and Chu, Ying and Lv, Jinpeng and Yun, Changjun
Journal: Journal of Orthopaedic Surgery and Research (2024): 241
Authors: Qian, Wenjie and Mei, Kai and Zhu, Lei and Chu, Ying and Lv, Jinpeng and Yun, Changjun
Journal: Journal of Orthopaedic Surgery and Research (2024): 241
References
View all 66 references: Citation Explorer
Soluble TRAIL gene and actinomycin D synergistically suppressed multiple metastasis of TRAIL-resistant colon cancer in the liver
Authors: Ishii M, Iwai M, Harada Y, Kishida T, Asada H, Shin-Ya M, Itoh Y, Imanishi J, Okanoue T, Mazda O.
Journal: Cancer Lett. (2006)
Authors: Ishii M, Iwai M, Harada Y, Kishida T, Asada H, Shin-Ya M, Itoh Y, Imanishi J, Okanoue T, Mazda O.
Journal: Cancer Lett. (2006)
Downregulation of inhibitor of apoptosis proteins in apoptotic human chondrocytes treated with tumor necrosis factor-alpha and actinomycin D
Authors: Yoshimura F, Kanno H, Uzuki M, Tajima K, Shimamura T, Sawai T.
Journal: Osteoarthritis Cartilage (2006): 435
Authors: Yoshimura F, Kanno H, Uzuki M, Tajima K, Shimamura T, Sawai T.
Journal: Osteoarthritis Cartilage (2006): 435
Anti-apoptotic effect of hepatocyte growth factor from actinomycin D in hepatocyte-derived HL7702 cells is associated with activation of PI3K/Akt signaling
Authors: Li W, Cai S, Cai L, Li X.
Journal: Toxicol Lett (2006): 142
Authors: Li W, Cai S, Cai L, Li X.
Journal: Toxicol Lett (2006): 142
Carbon monoxide protects hepatocytes from TNF-alpha/Actinomycin D by inhibition of the caspase-8-mediated apoptotic pathway
Authors: Kim HS, Loughran PA, Kim PK, Billiar TR, Zuckerbraun BS.
Journal: Biochem Biophys Res Commun (2006): 1172
Authors: Kim HS, Loughran PA, Kim PK, Billiar TR, Zuckerbraun BS.
Journal: Biochem Biophys Res Commun (2006): 1172
Single-dose actinomycin D: Efficacy in the prophylaxis of postmolar gestational trophoblastic neoplasia in adolescents with high-risk hydatidiform mole
Authors: Uberti EM, Diestel MC, Guimaraes FE, De Napoli G, Schmid H.
Journal: Gynecol Oncol (2006): 325
Authors: Uberti EM, Diestel MC, Guimaraes FE, De Napoli G, Schmid H.
Journal: Gynecol Oncol (2006): 325
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