AMC [7-Amino-4-methylcoumarin] CAS 26093-31-2

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Physical properties

Molecular weight	175.19
Solvent	DMSO

Spectral properties

Excitation (nm)	341
Emission (nm)	441

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501

Overview SDS Protocol

CAS

26093-31-2

Molecular weight

175.19

Excitation (nm)

341

Emission (nm)

441

This compound is the precursor for a variety of AMC enzyme substrates. It is also used as a calibration standard for AMC-based enzyme substrates. Fluorogenic AMC substrates are widely used for measuring a variety of protease activities.

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of AMC [7-Amino-4-methylcoumarin] *CAS 26093-31-2* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	570.809 µL	2.854 mL	5.708 mL	28.54 mL	57.081 mL
5 mM	114.162 µL	570.809 µL	1.142 mL	5.708 mL	11.416 mL
10 mM	57.081 µL	285.404 µL	570.809 µL	2.854 mL	5.708 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
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Spectrum

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Spectral properties

Excitation (nm)	341
Emission (nm)	441

Images

Figure 1. Chemical structure for AMC [7-Amino-4-methylcoumarin] *CAS 26093-31-2*

Citations

View all 1 citations: Citation Explorer

Modulation of CD4&plus; T-cell activation by CD95 co-stimulation
Authors: Paulsen, Maren and Valentin, Signe and Mathew, Biny and Adam-Klages, Sabine and Bertsch, Uwe and Lavrik, Inna and Krammer, Peter H and Kabelitz, Dieter and Janssen, Ottmar
Journal: Cell Death & Differentiation (2011): 619--631

References

View all 142 references: Citation Explorer

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Journal: Neurology (2006): 529

Active cathepsins B, H, K, L and S in human inflammatory bronchoalveolar lavage fluids
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Journal: Biol Cell (2006): 15

A role for Angiotensin-converting enzyme in the characterization, enrichment, and proliferation potential of adult murine pituitary colony-forming cells
Authors: Lepore DA, Jokubaitis VJ, Simmons PJ, Roeszler KN, Rossi R, Bauer K, Thomas PQ.
Journal: Stem Cells (2006): 2382

Paenidase, a Novel D-Aspartyl Endopeptidase from Paenibacillus sp. B38: Purification and Substrate Specificity
Authors: Takahashi S, Ogasawara H, Hiwatashi K, Hori K, Hata K, Tachibana T, Itoh Y, Sugiyama T.
Journal: J Biochem (Tokyo) (2006): 197

Recovery of free oligosaccharides from derivatives labeled by reductive amination
Authors: Suzuki S, Fujimori T, Yodoshi M.
Journal: Anal Biochem (2006): 94

Characterization and microbial utilization of dissolved organic carbon in groundwater contaminated with chlorophenols
Authors: Langwaldt JH, Munster U, Puhakka JA.
Journal: Chemosphere (2005): 983

Discovery of a sulfated tetrapeptide that binds to vascular endothelial growth factor
Authors: Maynard HD, Hubbell JA.
Journal: Acta Biomater (2005): 451

Mechanism of human SIRT1 activation by resveratrol
Authors: Borra MT, Smith BC, Denu JM.
Journal: J Biol Chem (2005): 17187

Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers
Authors: Herter S, Piper DE, Aaron W, Gabriele T, Cutler G, Cao P, Bhatt AS, Choe Y, Craik CS, Walker N, Meininger D, Hoey T, Austin RJ.
Journal: Biochem J (2005): 125

delta-(D -alpha-Aminoadipoyl)-cleaving amidase of Ochrobactrum anthropi
Authors: Patett F, Fischer L.
Journal: Biotechnol Lett (2005): 1915