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AMCA, succinimidyl ester

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Physical properties
Molecular weight330.29
Spectral properties
Correction Factor (280 nm)0.153
Extinction coefficient (cm -1 M -1)19000
Excitation (nm)346
Emission (nm)434
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
Alternative formats
AMCA Azide
AMCA Alkyne


Molecular weight
Correction Factor (280 nm)
Extinction coefficient (cm -1 M -1)
Excitation (nm)
Emission (nm)
AMCA is one of the brightest blue fluorescent labeling dyes. It can be well excited at 365 nm. It is quite photostable, and its fluorescence is pH-independent from pH 4 to 10. AMCA, succinimidyl ester can be used for labeling aliphatic amine compounds.


Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of AMCA, succinimidyl ester to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM302.764 µL1.514 mL3.028 mL15.138 mL30.276 mL
5 mM60.553 µL302.764 µL605.528 µL3.028 mL6.055 mL
10 mM30.276 µL151.382 µL302.764 µL1.514 mL3.028 mL

Molarity calculator

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Spectral properties

Correction Factor (280 nm)0.153
Extinction coefficient (cm -1 M -1)19000
Excitation (nm)346
Emission (nm)434



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Time-resolved energy transfer measurements of donor-acceptor distance distributions and intramolecular flexibility of a CCHH zinc finger peptide
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Journal: Biochemistry (1993): 7981
Improved indirect fluorescence immunocytochemical method using counterstains
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Journal: Biotechniques (1992): 536
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