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BAPTA, AM *CAS 126150-97-8*

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Physical properties
Molecular weight764.68
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure


Molecular weight
BAPTA AM is cell-permeable version of BAPTA (1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid), a cell-permeable calcium chelator. This BAPTA derivative is used for adjusting calcium concentrations in cells and tissues. BAPTA is a calcium-specific aminopolycarboxylic acid. The presence of four carboxylic acid functional groups makes possible the binding of two calcium ions. The extensive flexibility of the carboxylate ligands is critical to the coordination of calcium and other metal ions.


Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of BAPTA, AM *CAS 126150-97-8* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM130.774 µL653.868 µL1.308 mL6.539 mL13.077 mL
5 mM26.155 µL130.774 µL261.547 µL1.308 mL2.615 mL
10 mM13.077 µL65.387 µL130.774 µL653.868 µL1.308 mL

Molarity calculator

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View all 11 citations: Citation Explorer
Regulation of Calcium entry by cyclic GMP signaling in Toxoplasma gondii
Authors: Triana, Miryam A Hortua and M{\'a}rquez-Nogueras, Karla M and Fazli, Mojtaba Sedigh and Quinn, Shannon and Moreno, Silvia NJ
Journal: Journal of Biological Chemistry (2024): 105771
RNA granules hitchhike on lysosomes for long-distance transport, using annexin A11 as a molecular tether
Authors: Liao, Ya-Cheng and Fernandopulle, Michael S and Wang, Guozhen and Choi, Heejun and Hao, Ling and Drerup, Catherine M and Patel, Rajan and Qamar, Seema and Nixon-Abell, Jonathon and Shen, Yi and others,
Journal: Cell (2019): 147--164
The role of calcium signalling in autophagy
Authors: Chehab, Tala
Journal: (2018)
Angiotensin II regulates phosphorylation of actin-associated proteins in human podocytes
Authors: Schenk, Laura K and M{\"o}ller-Kerutt, Annika and Klosowski, Rafael and Wolters, Dirk and Schaffner-Reckinger, Elisabeth and Weide, Thomas and Pavenst{\"a}dt, Hermann and Vollenbr{\"o}ker, Beate
Journal: The FASEB Journal (2017): 5019--5035
Licochalcone A induces T24 bladder cancer cell apoptosis by increasing intracellular calcium levels
Authors: Yang, Xinhui and Jiang, Jiangtao and Yang, Xinyan and Han, Jichun and Zheng, Qiusheng
Journal: Molecular medicine reports (2016): 911--919
Helicobacter pylori induces IL-1&beta; protein through the inflammasome activation in differentiated macrophagic cells
Authors: Kameoka, Shoichiro and Kameyama, Takeshi and Hayashi, Takaya and Sato, Seiichi and Ohnishi, Naomi and Hayashi, Takeru and Murata-Kamiya, Naoko and Higashi, Hideaki and Hatakeyama, Masanori and Takaoka, Akinori
Journal: Biomedical Research (2016): 21--27
Spautin-1 Ameliorates Acute Pancreatitis via Inhibiting Impaired Autophagy and Alleviating Calcium Overload
Authors: Xiao, Juan and Feng, Xueping and Huang, Xiao-Ying and Huang, Zhongshi and Huang, Yanqiang and Li, Chaogan and Li, Genliang and Nong, Song and Wu, Ruoshi and Huang, Yongzhi and others, undefined
Journal: Molecular Medicine (2016): 643
Ras guanyl nucleotide releasing protein 2 affects cell viability and cell--matrix adhesion in ECV304 endothelial cells
Authors: Takino, Junichi and Nagamine, Kentaro and Hori, Takamitsu
Journal: Cell adhesion &amp; migration (2013): 262--266
Delayed administration of the nucleic acid analog 2Cl-C. OXT-A attenuates brain damage and enhances functional recovery after ischemic stroke
Authors: Okabe, Naohiko and Nakamura, Emi and Himi, Naoyuki and Narita, Kazuhiko and Tsukamoto, Ikuko and Maruyama, Tokumi and Sakakibara, Norikazu and Nakamura, Takehiro and Itano, Toshifumi and Miyamoto, Osamu
Journal: Brain research (2013): 115--131


View all 43 references: Citation Explorer
Determination of BAPTA-AM, the acetoxymethyl tetraester of BAPTA, in rat plasma by liquid chromatography tandem mass spectrometry
Authors: Zheng F, Hang T, Wu C, Di B, Liu W, Xu J, Zhai C, Sun D, Liu J, Wei W.
Journal: J Mass Spectrom (2006): 1615
Abrogation of DTH response and mitogenic lectin- and alloantigen-induced activation of lymphocytes by calcium inhibitors TMB-8 and BAPTA-AM
Authors: Saxena HM, Dikshit M.
Journal: Immunol Lett (2005): 60
BAPTA induces frequency shifts in vivo of spontaneous otoacoustic emissions of the bobtail lizard
Authors: Manley GA, Kirk DL.
Journal: Audiol Neurootol (2005): 248
Ca2+-dependent interaction of BAPTA with phospholipids
Authors: Rousset M, Cens T, Vanmau N, Charnet P.
Journal: FEBS Lett (2004): 41
Calcium-independent cytoskeleton disassembly induced by BAPTA
Authors: Saoudi Y, Rousseau B, Doussiere J, Charrasse S, Gauthier-Rouviere C, Morin N, Sautet-Laugier C, Denarier E, Scaife R, Mioskowski C, Job D.
Journal: Eur J Biochem (2004): 3255
Disturbed cooperation of hepatocytes in the rhythm of protein synthesis by chelating agent of cytoplasmic calcium BAPTA-AM
Authors: Zvesdina ND, Nechaeva NV, Gracheva EV, Novikova TE, Gvazava IG, Fateeva VI, Mal'chenko LA, Brodskii V.
Journal: Izv Akad Nauk Ser Biol (2003): 14
Loading neurons with BAPTA-AM activates xbp1 processing indicative of induction of endoplasmic reticulum stress
Authors: Paschen W, Hotop S, Aufenberg C.
Journal: Cell Calcium (2003): 83
Imaging of changes in sarcoplasmic reticulum [Ca(2+)] using Oregon Green BAPTA 5N and confocal laser scanning microscopy
Authors: White C, McGeown G.
Journal: Cell Calcium (2002): 151
BAPTA/AM, an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures
Authors: Wie MB, Koh JY, Won MH, Lee JC, Shin TK, Moon CJ, Ha HJ, Park SM, Kim HC.
Journal: Prog Neuropsychopharmacol Biol Psychiatry (2001): 1641
The calcium chelator BAPTA affects the binding of assembly protein AP-2 to membranes
Authors: Alberdi A, Jimenez-Ortiz V, Sosa MA.
Journal: Biocell (2001): 167