Calculator
BAPTA DBCO
BAPTA DBCO is an excellent building block to introduce BAPTA calcium chelator into a biological molecule that contains an azido group such as azido-modified antibodies, proteins, peptides and oligos via the copper-free click chemistry. Compared to BAPTA Alkyne, BAPTA DBCO requires much milder reaction conditions with higher reaction yield. BAPTA (1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid) is a common calcium-specific chelator. The presence of four carboxylic acid functional groups makes BAPTA possibly binding two calcium ions. The extensive flexibility of the carboxylate ligands is critical to the coordination of calcium and other metal ions. BAPTA is commonly used to chelate Ca2+, similarly to EGTA.
References
View all 50 references: Citation Explorer
Cellular effects of BAPTA: Are they only about Ca2+ chelation?
Authors: Sneyers, Flore and Speelman-Rooms, Femke and Verhelst, Steven H L and Bootman, Martin D and Bultynck, Geert
Journal: Biochimica et biophysica acta. Molecular cell research (2024): 119589
Authors: Sneyers, Flore and Speelman-Rooms, Femke and Verhelst, Steven H L and Bootman, Martin D and Bultynck, Geert
Journal: Biochimica et biophysica acta. Molecular cell research (2024): 119589
Calcium chelation independent effects of BAPTA on endogenous ANO6 channels in HEK293T cells.
Authors: Kolesnikov, D O and Nomerovskaya, M A and Grigorieva, E R and Reshetin, D S and Skobeleva, K V and Gusev, K O and Shalygin, A V and Kaznacheyeva, E V
Journal: Biochemical and biophysical research communications (2024): 149378
Authors: Kolesnikov, D O and Nomerovskaya, M A and Grigorieva, E R and Reshetin, D S and Skobeleva, K V and Gusev, K O and Shalygin, A V and Kaznacheyeva, E V
Journal: Biochemical and biophysical research communications (2024): 149378
Elimination of intracellular Ca2+ overload by BAPTA‑AM liposome nanoparticles: A promising treatment for acute pancreatitis.
Authors: Fu, Zailin and Wang, Dingsheng and Zheng, Caiyun and Xie, Minghua and Chen, Yifang and Zhou, Yi and Huang, Yan and Song, Ying and Hong, Weiyong
Journal: International journal of molecular medicine (2024)
Authors: Fu, Zailin and Wang, Dingsheng and Zheng, Caiyun and Xie, Minghua and Chen, Yifang and Zhou, Yi and Huang, Yan and Song, Ying and Hong, Weiyong
Journal: International journal of molecular medicine (2024)
Intracellular BAPTA directly inhibits PFKFB3, thereby impeding mTORC1-driven Mcl-1 translation and killing MCL-1-addicted cancer cells.
Authors: Sneyers, Flore and Kerkhofs, Martijn and Speelman-Rooms, Femke and Welkenhuyzen, Kirsten and La Rovere, Rita and Shemy, Ahmed and Voet, Arnout and Eelen, Guy and Dewerchin, Mieke and Tait, Stephen W G and Ghesquière, Bart and Bootman, Martin D and Bultynck, Geert
Journal: Cell death & disease (2023): 600
Authors: Sneyers, Flore and Kerkhofs, Martijn and Speelman-Rooms, Femke and Welkenhuyzen, Kirsten and La Rovere, Rita and Shemy, Ahmed and Voet, Arnout and Eelen, Guy and Dewerchin, Mieke and Tait, Stephen W G and Ghesquière, Bart and Bootman, Martin D and Bultynck, Geert
Journal: Cell death & disease (2023): 600
Calcium imaging and BAPTA loading of amygdala astrocytes in mouse brain slices.
Authors: Baudon, Angel and Clauss-Creusot, Etienne and Darbon, Pascal and Patwell, Ryan and Grinevich, Valery and Charlet, Alexandre
Journal: STAR protocols (2022): 101159
Authors: Baudon, Angel and Clauss-Creusot, Etienne and Darbon, Pascal and Patwell, Ryan and Grinevich, Valery and Charlet, Alexandre
Journal: STAR protocols (2022): 101159
Page updated on May 13, 2025
Safety data sheet