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BAPTA Tetrazine
BAPTA Tetrazine is an excellent building block to introduce BAPTA calcium chelator into a biological molecule that contains a TCO (trans‐cyclooctene) group such as TCO-modified antibodies, proteins, peptides and oligos via TCO-tetrazine ligation. The TCO‐tetrazine click reaction follows an inverse‐electron demand Diels‐Alder cycloaddition reaction of TCO with tetrazine. The bioorthogonal reaction possesses exceptional kinetics (k > 800 M‐1s‐1) and selectivity. Such excellent reaction rate constants are unparalleled by any other bioorthogonal reaction pair. BAPTA (1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid) is a common calcium-specific chelator. The presence of four carboxylic acid functional groups makes BAPTA possibly binding two calcium ions. The extensive flexibility of the carboxylate ligands is critical to the coordination of calcium and other metal ions. BAPTA is commonly used to chelate Ca2+, similarly to EGTA.
References
View all 50 references: Citation Explorer
A novel transient receptor potential C3/C6 selective activator induces the cellular uptake of antisense oligonucleotides.
Authors: Kohashi, Hiroto and Nagata, Ryu and Tamenori, Yusuke and Amatani, Tomorrow and Ueda, Yoshifumi and Mori, Yasuo and Kasahara, Yuuya and Obika, Satoshi and Shimojo, Masahito
Journal: Nucleic acids research (2024): 4784-4798
Authors: Kohashi, Hiroto and Nagata, Ryu and Tamenori, Yusuke and Amatani, Tomorrow and Ueda, Yoshifumi and Mori, Yasuo and Kasahara, Yuuya and Obika, Satoshi and Shimojo, Masahito
Journal: Nucleic acids research (2024): 4784-4798
Nitric oxide augments signaling for contraction in hypoxic pulmonary arterial smooth muscle-Implications for hypoxic pulmonary hypertension.
Authors: Hinton, Martha and Thliveris, James A and Hatch, Grant M and Dakshinamurti, Shyamala
Journal: Frontiers in physiology (2023): 1144574
Authors: Hinton, Martha and Thliveris, James A and Hatch, Grant M and Dakshinamurti, Shyamala
Journal: Frontiers in physiology (2023): 1144574
Sperm induce a secondary increase in ATP levels in mouse eggs that is independent of Ca2+ oscillations.
Authors: Ikie-Eshalomi, Cindy and Aliyev, Elnur and Hoehn, Sven and Jurkowski, Tomasz P and Swann, Karl
Journal: The Biochemical journal (2023): 2023-2035
Authors: Ikie-Eshalomi, Cindy and Aliyev, Elnur and Hoehn, Sven and Jurkowski, Tomasz P and Swann, Karl
Journal: The Biochemical journal (2023): 2023-2035
Rutaecarpine Prevents High Glucose-Induced Endothelial Cell Senescence Through Transient Receptor Potential Vanilloid Subtype 1/ SIRT1 Pathway.
Authors: Xiong, Yan and Wang, Han-Xia and Yan, Hang and Zhu, Si-Lu and Guo, Shu-Wen and Peng, Wei-Jie and Luo, Dan
Journal: Journal of cardiovascular pharmacology (2022): e129-e137
Authors: Xiong, Yan and Wang, Han-Xia and Yan, Hang and Zhu, Si-Lu and Guo, Shu-Wen and Peng, Wei-Jie and Luo, Dan
Journal: Journal of cardiovascular pharmacology (2022): e129-e137
Extracellular application of the N-methyl-D-aspartate receptor allosteric modulator rapastinel acts remotely to regulate Ca2+ inactivation at an intracellular locus.
Authors: Zhang, Xiao-Lei and Berglund, Nils A and Burgdorf, Jeffrey S and Donello, John E and Moskal, Joseph R and Stanton, Patric K
Journal: Neuroreport (2022): 312-319
Authors: Zhang, Xiao-Lei and Berglund, Nils A and Burgdorf, Jeffrey S and Donello, John E and Moskal, Joseph R and Stanton, Patric K
Journal: Neuroreport (2022): 312-319
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