Name: Beta-Amyloid (1-42)
Brand: AAT Bioquest
SKU: 81100
Price: 250 USD
Availability: InStock

Beta-Amyloid (1-42)

Beta-amyloid (1-42) (Aβ1-42) is a 42-amino acid peptide that is the primary pathogenic species associated with Alzheimer's disease (AD).

Sequence Length: 42 amino acids from the N-terminal region of the full Aβ peptide
Hydrophilicity: Highly hydrophobic, making it more prone to aggregation compared to Abeta(1-28) and Abeta(1-40)
Biomarker: It is used as a highly accurate diagnostic marker for AD pathology

Chemical structure of Beta-Amyloid (1-42).

Datasheet

SDS

COA

Catalog	Size	Price	Quantity
81100	1 mg	Price

Overview

Beta-amyloid (1-42) (Aβ1-42) is a 42-amino acid peptide that is the primary pathogenic species associated with Alzheimer's disease (AD). It has the amino acid sequence of H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH (DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA). It is a major component of the amyloid plaques that accumulate in the brains of patients with AD, a hallmark of the disease. Aβ1-42 is produced by the sequential cleavage of a larger protein, the amyloid precursor protein (APP), by two enzymes: beta-secretase and gamma-secretase. In Alzheimer's disease, the production and/or clearance of Aβ1-42 are dysregulated, leading to its accumulation. It is highly hydrophobic and prone to misfolding and aggregating into small, toxic oligomers and larger, insoluble fibrils. These aggregates form the amyloid plaques found between neurons in the brain. Aβ1-42 has a much higher propensity to aggregate into amyloid fibrils than the more abundant, shorter Aβ1-40 form. This aggregation is believed to be an initial event in the progression of AD, potentially initiating neurotoxic processes like synaptic dysfunction, chronic inflammation, and ultimately, nerve cell death. The ratio of Aβ1-42 to Aβ1-40 is used as a highly accurate diagnostic marker for AD pathology. It is also a drug target for developing AD medicines. AAT Bioquest’s beta-Amyloid (1-42) material is thoroughly analyzed to ensure its quality by HPLC, electrophoresis and cell functional analysis.

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Beta-Amyloid (1-42) to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	22.153 µL	110.765 µL	221.529 µL	1.108 mL	2.215 mL
5 mM	4.431 µL	22.153 µL	44.306 µL	221.529 µL	443.058 µL
10 mM	2.215 µL	11.076 µL	22.153 µL	110.765 µL	221.529 µL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	4514.08 g/mol	=	mL	x	mM	=	mmol

References

View all 50 references: Citation Explorer

An integrative and efficient microbiosensor for β-amyloid42 based on a molecularly imprinted layer coordinating built-in hemin on the acupuncture needle.

Authors:

Kong, Xue and Yu, Zimei and Sun, Qinghua and Liu, Yan and Yin, Zheng-Zhi

Journal:

Bioelectrochemistry (Amsterdam, Netherlands) (2026): 109095

Longitudinal plasma proteomic evidence linking SARS-CoV-2 infection to increased β-amyloid pathology.

Authors:

Yuan, Shiqi and Xu, Jun

Journal:

Science China. Life sciences (2025): 3792-3793

RvD1 signaling in peripheral macrophages promotes systemic β-amyloid clearance to mitigate the progression of perioperative neurocognitive disorders in mice.

Authors:

Ding, Yi and Xing, Guang-Yuan and Mao, Zhen-Yun and Zhang, Zhi-Yuan and Li, Yong-Qiang and Xu, Lu

Journal:

Experimental neurology (2025): 115486

Prediction of continuous amyloid positron emission tomography with fluid measures of phosphorylated tau and β-amyloid.

Authors:

Mattsson-Carlgren, Niklas and Karlsson, Linda and Tang, Weizhong and Blennow, Kaj and Zetterberg, Henrik and Bateman, Randall J and Schindler, Suzanne E and Barthelemy, Nicolas and Palmqvist, Sebastian and Stomrud, Erik and Janelidze, Shorena and Hansson, Oskar

Journal:

EMBO molecular medicine (2025)

Cell-weighted polygenic risk scores are associated with β-amyloid and tau biomarkers in Alzheimer's disease.

Authors:

Kumar, Atul and Pichet Binette, Alexa and Bali, Divya and Janelidze, Shorena and Stomrud, Erik and Palmqvist, Sebastian and Vogel, Jacob W and Hansson, Oskar and Mattsson-Carlgren, Niklas

Journal:

Brain communications (2025): fcaf353

Physical properties

Molecular weight	4514.08
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
CAS	107761-42-2

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Page updated on April 4, 2026