Beta-trifluoromethylumbelliferone [7-Hydroxy-4-trifluoromethylcoumarin] *CAS 575-03-1*

Beta-trifluoromethylumbelliferone

7-Hydroxy-4-trifluoromethylcoumarin; CAS 575-03-1

This coumarin compound is used as a calibration standard for 7-hydroxy-4-trifluoromethylcoumarin-based enzyme substrates. It has pH-dependent fluorescence.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
82	100 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Beta-trifluoromethylumbelliferone [7-Hydroxy-4-trifluoromethylcoumarin] *CAS 575-03-1* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	434.518 µL	2.173 mL	4.345 mL	21.726 mL	43.452 mL
5 mM	86.904 µL	434.518 µL	869.036 µL	4.345 mL	8.69 mL
10 mM	43.452 µL	217.259 µL	434.518 µL	2.173 mL	4.345 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	230.14 g/mol	=	mL	x	mM	=	mmol

References

View all 15 references: Citation Explorer

Determination of CYP2B6 component of 7-ethoxy-4-trifluoromethylcoumarin O-deethylation activity in human liver microsomes

Authors:

Chang TK, Crespi CL, Waxman DJ.

Journal:

Methods Mol Biol (2006): 97

Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases

Authors:

Sridar C, Goosen TC, Kent UM, Williams JA, Hollenberg PF.

Journal:

Drug Metab Dispos (2004): 587

Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of posaconazole (Noxafil)

Authors:

Ghosal A, Hapangama N, Yuan Y, Achanfuo-Yeboah J, Iannucci R, Chowdhury S, Alton K, Patrick JE, Zbaida S.

Journal:

Drug Metab Dispos (2004): 267

Generation and validation of rapid computational filters for cyp2d6 and cyp3a4

Authors:

Ekins S, Berbaum J, Harrison RK.

Journal:

Drug Metab Dispos (2003): 1077

Functional characterization of wild-type and variant (T202I and M59I) human UDP-glucuronosyltransferase 1A10

Authors:

Jinno H, Saeki M, Tanaka-Kagawa T, Hanioka N, Saito Y, Ozawa S, Ando M, Shirao K, Minami H, Ohtsu A, Yoshida T, Saijo N, Sawada J.

Journal:

Drug Metab Dispos (2003): 528

Physical properties

Molecular weight	230.14
Solvent	DMSO

Spectral properties

Excitation (nm)	385
Emission (nm)	499

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501
CAS	575-03-1

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