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BG Succinimidyl Ester

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InternationalSee distributors
ShippingStandard overnight for United States, inquire for international
Physical properties
Molecular weight481.47
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
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Molecular weight
SNAP protein labeling system enables the specific, covalent attachment of virtually any molecule to a protein of interest. The SNAP-tag is a protein based on human O6-alkylguanine-DNA-alkyltransferase (hAGT). SNAP-tag substrates are fluorophores, biotin or beads conjugated to guanine or chloropyrimidine leaving groups via a benzyl linker. In the labeling reaction, the substituted benzyl group of the substrate is covalently attached to the SNAP-tag. BG Succinimidyl Ester is an amine-reactive building block for preparing of SNAP substrates from amine-containing labels or biological targets. BG Succinimidyl Ester building block facilities the development of various SNAP-tag substrates for labeling SNAP-tag fusion proteins for a wide range of biological applications.


Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of BG Succinimidyl Ester to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM207.697 µL1.038 mL2.077 mL10.385 mL20.77 mL
5 mM41.539 µL207.697 µL415.395 µL2.077 mL4.154 mL
10 mM20.77 µL103.849 µL207.697 µL1.038 mL2.077 mL

Molarity calculator

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View all 50 references: Citation Explorer
Photo-SNAP-tag, a Light-Regulated Chemical Labeling System.
Authors: Cleveland, Joseph D and Tucker, Chandra L
Journal: ACS chemical biology (2020)
The covalent SNAP tag for protein display quantification and low-pH protein engineering.
Authors: Jin, Wei and Madan, Bharat and Mussman, Brooklyn K and Hailemariam, Amen T and Fahad, Ahmed S and Wolfe, Jacy R and Kwon, Young Do and Zhang, Baoshan and Shapiro, Lawrence and Kwong, Peter D and DeKosky, Brandon J
Journal: Journal of biotechnology (2020): 50-56
Visualizing and Manipulating Biological Processes by Using HaloTag and SNAP-Tag Technologies.
Authors: Hoelzel, Conner A and Zhang, Xin
Journal: Chembiochem : a European journal of chemical biology (2020): 1935-1946
[Combined application of SNAP-tag and fluorescence technique in in-situ protein analysis].
Authors: Qiao, Qinglong and Zhou, Wei and Chen, Jie and Liu, Wenjuan and Miao, Lu and Yin, Wenting and Xu, Zhaochao
Journal: Se pu = Chinese journal of chromatography (2019): 872-877
A SNAP-tag fluorogenic probe mimicking the chromophore of the red fluorescent protein Kaede.
Authors: Jung, Kwan Ho and Fares, Matthew and Grainger, Leeann S and Wolstenholme, Charles H and Hou, Anna and Liu, Yu and Zhang, Xin
Journal: Organic & biomolecular chemistry (2019): 1906-1915
One-step site-specific antibody fragment auto-conjugation using SNAP-tag technology.
Authors: Hussain, Ahmad Fawzi and Heppenstall, Paul A and Kampmeier, Florian and Meinhold-Heerlein, Ivo and Barth, Stefan
Journal: Nature protocols (2019): 3101-3125
Applications of SNAP-tag technology in skin cancer therapy.
Authors: Padayachee, Eden Rebecca and Adeola, Henry Ademola and Van Wyk, Jennifer Catherine and Nsole Biteghe, Fleury Augustine and Chetty, Shivan and Khumalo, Nonhlanhla Patience and Barth, Stefan
Journal: Health science reports (2019): e103
Beyond O6-Benzylguanine: O6-(5-Pyridylmethyl)guanine as a Substrate for the Self-Labeling Enzyme SNAP-Tag.
Authors: Macias-Contreras, Miguel and He, Huan and Zhu, Lei
Journal: Bioconjugate chemistry (2018): 4104-4109
Imaging Newly Synthesized and Old Histone Variant Dynamics Dependent on Chaperones Using the SNAP-Tag System.
Authors: Torné, Júlia and Orsi, Guillermo A and Ray-Gallet, Dominique and Almouzni, Geneviève
Journal: Methods in molecular biology (Clifton, N.J.) (2018): 207-221
SNAP-Tag-Based Subcellular Protein Labeling and Fluorescent Imaging with Naphthalimides.
Authors: Wang, Chao and Song, Xinbo and Xiao, Yi
Journal: Chembiochem : a European journal of chemical biology (2017): 1762-1769