BG Succinimidyl Ester

SNAP protein labeling system enables the specific, covalent attachment of virtually any molecule to a protein of interest. The SNAP-tag is a protein based on human O6-alkylguanine-DNA-alkyltransferase (hAGT). SNAP-tag substrates are fluorophores, biotin or beads conjugated to guanine or chloropyrimidine leaving groups via a benzyl linker. In the labeling reaction, the substituted benzyl group of the substrate is covalently attached to the SNAP-tag. BG Succinimidyl Ester is an amine-reactive building block for preparing of SNAP substrates from amine-containing labels or biological targets. BG Succinimidyl Ester building block facilities the development of various SNAP-tag substrates for labeling SNAP-tag fusion proteins for a wide range of biological applications.

Protocol

SDS

COO

COA

Catalog	Size	Price	Quantity
12564	1 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of BG Succinimidyl Ester to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	207.697 µL	1.038 mL	2.077 mL	10.385 mL	20.77 mL
5 mM	41.539 µL	207.697 µL	415.395 µL	2.077 mL	4.154 mL
10 mM	20.77 µL	103.849 µL	207.697 µL	1.038 mL	2.077 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	481.47 g/mol	=	mL	x	mM	=	mmol

References

View all 50 references: Citation Explorer

Photo-SNAP-tag, a Light-Regulated Chemical Labeling System.

Authors:

Cleveland, Joseph D and Tucker, Chandra L

Journal:

ACS chemical biology (2020)

The covalent SNAP tag for protein display quantification and low-pH protein engineering.

Authors:

Jin, Wei and Madan, Bharat and Mussman, Brooklyn K and Hailemariam, Amen T and Fahad, Ahmed S and Wolfe, Jacy R and Kwon, Young Do and Zhang, Baoshan and Shapiro, Lawrence and Kwong, Peter D and DeKosky, Brandon J

Journal:

Journal of biotechnology (2020): 50-56

Visualizing and Manipulating Biological Processes by Using HaloTag and SNAP-Tag Technologies.

Authors:

Hoelzel, Conner A and Zhang, Xin

Journal:

Chembiochem : a European journal of chemical biology (2020): 1935-1946

[Combined application of SNAP-tag and fluorescence technique in in-situ protein analysis].

Authors:

Qiao, Qinglong and Zhou, Wei and Chen, Jie and Liu, Wenjuan and Miao, Lu and Yin, Wenting and Xu, Zhaochao

Journal:

Se pu = Chinese journal of chromatography (2019): 872-877

A SNAP-tag fluorogenic probe mimicking the chromophore of the red fluorescent protein Kaede.

Authors:

Jung, Kwan Ho and Fares, Matthew and Grainger, Leeann S and Wolstenholme, Charles H and Hou, Anna and Liu, Yu and Zhang, Xin

Journal:

Organic & biomolecular chemistry (2019): 1906-1915

Physical properties

Molecular weight	481.47
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501

Documents

Protocol
Safety Data Sheet
Certificate of Origin
Certificate of Analysis

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Page updated on November 20, 2025