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BG-TMR Conjugate
Site-specific labeling of cellular proteins with chemical probes is a powerful tool for studying protein functions in living cells. The SNAP-tag is a modified form of the DNA repair enzyme, human O6-alkylguanine-DNA-alkyltransferase (AGT) and undergoes a self-labeling reaction to form a covalent bond with O6-benzylguanine (BG) derivatives. BG-TMR conjugate is a fluorescent SNAP substrate that can be used to label SNAP tag-fused target proteins. In the labeling reaction, the substituted benzyl group of the substrate is covalently attached to the SNAP-tag. SNAP-TMR substrate enables the specific, covalent attachment of TMR fluorophore to a protein of interest. The labeled proteins can be imaged with TRITC or Cy3 filter set.
References
View all 50 references: Citation Explorer
Revealing receptor-ligand interactions of atypical antipsychotic drugs and screening anti-schizophrenia ingredients in Magnolia officinalis based on 5-HTR2A-SNAP-Tag/CMC and DRD2-SNAP-Tag/CMC models.
Authors: Gao, Chunlei and Zhou, Tongpei and Liu, Sihan and Miao, Chenyang and Feng, Jingting and Ding, Yifan and Lv, Yanni
Journal: Journal of chromatography. A (2024): 464784
Authors: Gao, Chunlei and Zhou, Tongpei and Liu, Sihan and Miao, Chenyang and Feng, Jingting and Ding, Yifan and Lv, Yanni
Journal: Journal of chromatography. A (2024): 464784
KIT-SNAP-tag/cell membrane chromatography model coupled with liquid chromatography-mass spectrometry for anti-GIST compound screening from Evodia rutaecarpa.
Authors: Feng, Jingting and Jiang, Yuhan and Liu, Sihan and Deng, Linge and Lv, Yanni and Chen, Nanzheng and Han, Shengli
Journal: Analytical and bioanalytical chemistry (2024): 1457-1468
Authors: Feng, Jingting and Jiang, Yuhan and Liu, Sihan and Deng, Linge and Lv, Yanni and Chen, Nanzheng and Han, Shengli
Journal: Analytical and bioanalytical chemistry (2024): 1457-1468
Mapping histone variant genomic distribution: Exploiting SNAP-tag labeling to follow the dynamics of incorporation of H3 variants.
Authors: Forest, Audrey and Quivy, Jean-Pierre and Almouzni, Geneviève
Journal: Methods in cell biology (2024): 49-65
Authors: Forest, Audrey and Quivy, Jean-Pierre and Almouzni, Geneviève
Journal: Methods in cell biology (2024): 49-65
Application of SNAP-tag-EGFR cell membrane chromatography model in screening antitumor active components of Silybum marianum (L.) Gaertn.
Authors: Zhang, Xin and Jiang, Yuhan and Guo, Na and Ding, Yifan and Feng, Jingting and Miao, Chenyang and Lv, Yanni
Journal: Journal of pharmaceutical and biomedical analysis (2024): 115816
Authors: Zhang, Xin and Jiang, Yuhan and Guo, Na and Ding, Yifan and Feng, Jingting and Miao, Chenyang and Lv, Yanni
Journal: Journal of pharmaceutical and biomedical analysis (2024): 115816
The Evolution of SNAP-Tag Labels.
Authors: Dreyer, Rudolf and Pfukwa, Rueben and Barth, Stefan and Hunter, Roger and Klumperman, Bert
Journal: Biomacromolecules (2023): 517-530
Authors: Dreyer, Rudolf and Pfukwa, Rueben and Barth, Stefan and Hunter, Roger and Klumperman, Bert
Journal: Biomacromolecules (2023): 517-530
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