Calculator
(-)-Blebbistatin *CAS#: 856925-71-8*
Ordering information
| Price | |
| Catalog Number | |
| Unit Size | |
| Quantity |
Additional ordering information
| Telephone | 1-800-990-8053 |
| Fax | 1-800-609-2943 |
| sales@aatbio.com | |
| International | See distributors |
| Bulk request | Inquire |
| Custom size | Inquire |
| Shipping | Standard overnight for United States, inquire for international |
Physical properties
| Molecular weight | 292.33 |
| Solvent | DMSO |
Storage, safety and handling
| H-phrase | H303, H313, H333 |
| Hazard symbol | XN |
| Intended use | Research Use Only (RUO) |
| R-phrase | R20, R21, R22 |
| Storage | Freeze (< -15 °C); Minimize light exposure |
| UNSPSC | 12352200 |
| Overview |  SDSProtocol |
CAS 856925-71-8 | Molecular weight 292.33 |
(-)-Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of 2 µM. It does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly.
Calculators
Common stock solution preparation
Table 1. Volume of DMSO needed to reconstitute specific mass of (-)-Blebbistatin *CAS#: 856925-71-8* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 342.079 µL | 1.71 mL | 3.421 mL | 17.104 mL | 34.208 mL |
| 5 mM | 68.416 µL | 342.079 µL | 684.158 µL | 3.421 mL | 6.842 mL |
| 10 mM | 34.208 µL | 171.04 µL | 342.079 µL | 1.71 mL | 3.421 mL |
Molarity calculator
Enter any two values (mass, volume, concentration) to calculate the third.
| Mass (Calculate) | Molecular weight | Volume (Calculate) | Concentration (Calculate) | Moles | ||||
| / | = | x | = |
Images
Figure 1. Chemical structure for (-)-Blebbistatin *CAS#: 856925-71-8*
References
View all 41 references: Citation Explorer
The mechanical uncoupler blebbistatin is associated with significant electrophysiological effects in the isolated rabbit heart
Authors: Brack KE, Narang R, Winter J, Ng GA.
Journal: Exp Physiol (2013): 1009
Authors: Brack KE, Narang R, Winter J, Ng GA.
Journal: Exp Physiol (2013): 1009
Homology model of nonmuscle myosin heavy chain IIA and binding mode analysis with its inhibitor blebbistatin
Authors: Lv Y, Lu S, Lu T, Kou J, Yu B.
Journal: J Mol Model (2013): 1801
Authors: Lv Y, Lu S, Lu T, Kou J, Yu B.
Journal: J Mol Model (2013): 1801
Enrichment of cell populations in metaphase, anaphase, and telophase by synchronization using nocodazole and blebbistatin: a novel method suitable for examining dynamic changes in proteins during mitotic progression
Authors: Matsui Y, Nakayama Y, Okamoto M, Fukumoto Y, Yamaguchi N.
Journal: Eur J Cell Biol (2012): 413
Authors: Matsui Y, Nakayama Y, Okamoto M, Fukumoto Y, Yamaguchi N.
Journal: Eur J Cell Biol (2012): 413
Modifications of mechanoelectric feedback induced by 2,3-butanedione monoxime and Blebbistatin in Langendorff-perfused rabbit hearts
Authors: Brines L, Such-Miquel L, Gallego D, Trapero I, Del Canto I, Zarzoso M, Soler C, Pelechano F, Canoves J, Alberola A, Such L, Chorro FJ.
Journal: Acta Physiol (Oxf) (2012): 29
Authors: Brines L, Such-Miquel L, Gallego D, Trapero I, Del Canto I, Zarzoso M, Soler C, Pelechano F, Canoves J, Alberola A, Such L, Chorro FJ.
Journal: Acta Physiol (Oxf) (2012): 29
Blebbistatin, a myosin inhibitor, is phototoxic to human cancer cells under exposure to blue light
Authors: Mikulich A, Kavaliauskiene S, Juzenas P.
Journal: Biochim Biophys Acta (2012): 870
Authors: Mikulich A, Kavaliauskiene S, Juzenas P.
Journal: Biochim Biophys Acta (2012): 870
The role of dynamic instability and wavelength in arrhythmia maintenance as revealed by panoramic imaging with blebbistatin vs. 2,3-butanedione monoxime
Authors: Lou Q, Li W, Efimov IR.
Journal: Am J Physiol Heart Circ Physiol (2012): H262
Authors: Lou Q, Li W, Efimov IR.
Journal: Am J Physiol Heart Circ Physiol (2012): H262
Properties of blebbistatin for cardiac optical mapping and other imaging applications
Authors: Swift LM, Asfour H, Posnack NG, Arutunyan A, Kay MW, Sarvazyan N.
Journal: Pflugers Arch (2012): 503
Authors: Swift LM, Asfour H, Posnack NG, Arutunyan A, Kay MW, Sarvazyan N.
Journal: Pflugers Arch (2012): 503
Inhibition of suicidal erythrocyte death by blebbistatin
Authors: Lang E, Qadri SM, Zelenak C, Gu S, Rotte A, Draeger A, Lang F.
Journal: Am J Physiol Cell Physiol (2011): C490
Authors: Lang E, Qadri SM, Zelenak C, Gu S, Rotte A, Draeger A, Lang F.
Journal: Am J Physiol Cell Physiol (2011): C490
Perivascular delivery of blebbistatin reduces neointimal hyperplasia after carotid injury in the mouse
Authors: Huang J, Zhang J, Pathak A, Li J, Stouffer GA.
Journal: J Pharmacol Exp Ther (2011): 116
Authors: Huang J, Zhang J, Pathak A, Li J, Stouffer GA.
Journal: J Pharmacol Exp Ther (2011): 116
In vitro and in vivo relaxation of urinary bladder smooth muscle by the selective myosin II inhibitor, blebbistatin
Authors: Zhang X, Kuppam DS, Melman A, DiSanto ME.
Journal: BJU Int (2011): 310
Authors: Zhang X, Kuppam DS, Melman A, DiSanto ME.
Journal: BJU Int (2011): 310