(-)-Blebbistatin *CAS#: 856925-71-8*

(-)-Blebbistatin

CAS#: 856925-71-8

(-)-Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of 2 µM. It does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
80001	1 mg	Price

References

View all 41 references: Citation Explorer

The mechanical uncoupler blebbistatin is associated with significant electrophysiological effects in the isolated rabbit heart

Authors:

Brack KE, Narang R, Winter J, Ng GA.

Journal:

Exp Physiol (2013): 1009

Homology model of nonmuscle myosin heavy chain IIA and binding mode analysis with its inhibitor blebbistatin

Authors:

Lv Y, Lu S, Lu T, Kou J, Yu B.

Journal:

J Mol Model (2013): 1801

Enrichment of cell populations in metaphase, anaphase, and telophase by synchronization using nocodazole and blebbistatin: a novel method suitable for examining dynamic changes in proteins during mitotic progression

Authors:

Matsui Y, Nakayama Y, Okamoto M, Fukumoto Y, Yamaguchi N.

Journal:

Eur J Cell Biol (2012): 413

Modifications of mechanoelectric feedback induced by 2,3-butanedione monoxime and Blebbistatin in Langendorff-perfused rabbit hearts

Authors:

Brines L, Such-Miquel L, Gallego D, Trapero I, Del Canto I, Zarzoso M, Soler C, Pelechano F, Canoves J, Alberola A, Such L, Chorro FJ.

Journal:

Acta Physiol (Oxf) (2012): 29

Blebbistatin, a myosin inhibitor, is phototoxic to human cancer cells under exposure to blue light

Authors:

Mikulich A, Kavaliauskiene S, Juzenas P.

Journal:

Biochim Biophys Acta (2012): 870

Physical properties

Molecular weight	292.33
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12352200
CAS	856925-71-8

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