BOC-Asp(OMe)-FMK [Boc-D(OMe)-FMK]

BOC-Asp(OMe)-FMK

Boc-D(OMe)-FMK

The FMK peptides are potent, cell permeable, irreversible capase inhibitors. It is useful for detecting and monitoring apoptosis in vitro and in vivo applications. BOC-ASP(OMe)-FMK is the key intermediate for developing and preparing FMK-based capase inhibitors and probes. The Asp(OMe)-FMK-based caspase inhibitors are cell permeable and irreversibly binds to activated caspases to block apoptosis. Caspases, which act as molecular chainsaw are the central components of apoptosis response. Caspases are cysteine proteases that cleave after aspartate residue in their substrates. At least 7 of 14 known mammalian caspases have important role in apoptosis.

Protocol

COA

Catalog	Size	Price	Quantity
5310	1 mg	Price
5311	10 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMF needed to reconstitute specific mass of BOC-Asp(OMe)-FMK [Boc-D(OMe)-FMK] to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	379.838 µL	1.899 mL	3.798 mL	18.992 mL	37.984 mL
5 mM	75.968 µL	379.838 µL	759.676 µL	3.798 mL	7.597 mL
10 mM	37.984 µL	189.919 µL	379.838 µL	1.899 mL	3.798 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	263.27 g/mol	=	mL	x	mM	=	mmol

References

View all 31 references: Citation Explorer

Leucine-rich amelogenin peptide induces osteogenesis by activation of the Wnt pathway

Authors:

Warotayanont R, Frenkel B, Snead ML, Zhou Y.

Journal:

Biochem Biophys Res Commun (2009): 558

Design of nontoxic analogues of cathelicidin-derived bovine antimicrobial peptide BMAP-27: the role of leucine as well as phenylalanine zipper sequences in determining its toxicity

Authors:

Ahmad A, Azmi S, Srivastava RM, Srivastava S, P and ey BK, Saxena R, Bajpai VK, Ghosh JK.

Journal:

Biochemistry (2009): 10905

A glycine-leucine-rich peptide structurally related to the plasticins from skin secretions of the frog Leptodactylus laticeps (Leptodactylidae)

Authors:

Conlon JM, Abdel-Wahab YH, Flatt PR, Leprince J, Vaudry H, Jouenne T, Condamine E.

Journal:

Peptides (2009): 888

Leucine-rich amelogenin peptide induces osteogenesis in mouse embryonic stem cells

Authors:

Warotayanont R, Zhu D, Snead ML, Zhou Y.

Journal:

Biochem Biophys Res Commun (2008): 1

Leucine-rich glioma inactivated 3 is involved in amyloid beta peptide uptake by astrocytes and endocytosis itself

Authors:

Okabayashi S, Kimura N.

Journal:

Neuroreport (2008): 1175

Physical properties

Molecular weight	263.27
Solvent	DMF

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12352200
CAS	187389-53-3

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Page updated on October 12, 2025