Bodi Fluor™ 488-Cephaeline Conjugate

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Physical properties

Molecular weight	740.70
Solvent	DMSO

Spectral properties

Correction Factor (260 nm)	0.015
Correction Factor (280 nm)	0.018
Extinction coefficient (cm ^-1 M ^-1)	81000
Excitation (nm)	504
Emission (nm)	510

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501

Overview SDS Protocol

Molecular weight

740.70

Correction Factor (260 nm)

0.015

Correction Factor (280 nm)

0.018

Extinction coefficient (cm ^-1 M ^-1)

81000

Excitation (nm)

504

Emission (nm)

510

Cephaeline is an alkaloid that is found in Cephaelis ipecacuanha and other plant species including Psychotria acuminate. Cephaeline induces vomiting by stimulating the stomach lining and is found in commercial products such as syrup of ipecac. Chemically, it is closely related to emetine. It has been reported that the expectorant action of ipecacuanha is due in whole or in major part to its content of emetine and cephaeline. The expectorant action of synthetic 2-dehydroemetine is essentially similar to that of emetine and cephaeline. This Bodipy-labeled has been used to study the mechanism of cephaeline.

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Bodi Fluor™ 488-Cephaeline Conjugate to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	135.007 µL	675.037 µL	1.35 mL	6.75 mL	13.501 mL
5 mM	27.001 µL	135.007 µL	270.015 µL	1.35 mL	2.7 mL
10 mM	13.501 µL	67.504 µL	135.007 µL	675.037 µL	1.35 mL

Molarity calculator

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Spectrum

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Spectral properties

Correction Factor (260 nm)	0.015
Correction Factor (280 nm)	0.018
Extinction coefficient (cm ^-1 M ^-1)	81000
Excitation (nm)	504
Emission (nm)	510

Images

Figure 1. Chemical structure for Bodi Fluor™ 488-Cephaeline Conjugate

References

View all 17 references: Citation Explorer

distribution and excretion of 3H-labeled cephaeline- and emetine-spiked ipecac syrup in rats
Authors: Asano, T.; Ishihara, K.; Wakui, Y.; Yanagisawa, T.; Kimura, M.; Kamei, H.; Yoshida, T.; Kuroiwa, Y.; Fujii, Y.; Yamashita, M.; Kuramochi, T.; Tomisawa, H.; Tateishi, M., Absorption
Journal: Eur J Drug Metab Pharmacokinet (2002): 17-27

Biotransformation of the ipecac alkaloids cephaeline and emetine from ipecac syrup in rats
Authors: Asano, T.; Watanabe, J.; Sadakane, C.; Ishihara, K.; Hirakura, K.; Wakui, Y.; Yanagisawa, T.; Kimura, M.; Kamei, H.; Yoshida, T.; Fujii, Y.; Yamashita, M.
Journal: Eur J Drug Metab Pharmacokinet (2002): 29-35

High-performance liquid chromatographic assay with fluorescence detection for the determination of cephaeline and emetine in human plasma and urine
Authors: Asano, T.; Sadakane, C.; Ishihara, K.; Yanagisawa, T.; Kimura, M.; Kamei, H.
Journal: J Chromatogr B Biomed Sci Appl (2001): 197-206

and their inhibitory effects on P450 enzyme activities
Authors: Asano, T.; Kushida, H.; Sadakane, C.; Ishihara, K.; Wakui, Y.; Yanagisawa, T.; Kimura, M.; Kamei, H.; Yoshida, T., Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, undefined
Journal: Biol Pharm Bull (2001): 678-82

in pharmaceutical preparations by high-performance liquid chromatography using spectrofluorimetric detection
Authors: Elvidge, D. A.; Johnson, G. W.; Harrison, J. R., Selective, stability-indicating assay of the major ipecacuanha alkaloids, emetine and cephaeline, undefined
Journal: J Chromatogr (1989): 107-18

Production of the alkaloids emetine and cephaeline in callus cultures of Cephaelis ipecacuanha
Authors: Jha, S.; Sahu, N. P.; Mahato, S. B.
Journal: Planta Med (1988): 504-6

Quantitative analysis of emetine and cephaeline by reversed-phase high performance liquid chromatography with fluorescence detection
Authors: Crouch, D. J.; Moran, D. M.; Finkle, B. S.; Peat, M. A.
Journal: J Anal Toxicol (1984): 63-5

The simultaneous assay of emetine and cephaeline in ipecacuanha and its preparations by spectrofluorimetry
Authors: Davidson, A. G.; Hassan, S. M.
Journal: J Pharm Biomed Anal (1984): 441-8

Determination of cephaeline in Radix Ipecacuanhae
Authors: Sobiczewska, M.; Borkowski, B.
Journal: Acta Pol Pharm (1970): 469-72

A new method for the determination of total alkaloids and of cephaeline in Ipecacuanha
Authors: Graf, E.; Ronsberg, W.
Journal: Arch Pharm Ber Dtsch Pharm Ges (1970): 209-17