Buccutite™ Fc Site-Specific MTA Antibody Modification Kit is designed for selective modification of antibodies with MTA groups through Fc region-specific Buccutite™ modification chemistry. The Buccutite™ technology selectively targets accessible Fc glycans for controlled antibody modification while minimizing labeling within antigen-binding regions. This site-specific approach helps preserve antibody binding activity and generates more uniform antibody conjugates compared to random lysine-labeling methods. The kit is optimized for labeling 100 µg protein per reaction and offers a cost-effective approach for preparing Fc-specific MTA-modified antibodies for downstream conjugation workflows.

The resulting MTA-modified antibodies are designed for covalent conjugation with Buccutite™ FOL-functionalized biomolecules under mild neutral conditions. Buccutite™ Fc site-specific modification technology provides a controlled alternative to random lysine-labeling approaches for generating more uniform antibody conjugates under mild reaction conditions.