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AAT Bioquest


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InternationalSee distributors
ShippingStandard overnight for United States, inquire for international
Physical properties
Molecular weight401.27
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure


Molecular weight
cAMP-AM is the cell-permeant cAMP. After permeation and metabolic activation by esterases the polar cAMP is released which is trapped inside the cell and subsequently metabolized quickly, resulting in a pulse-type signal. cAMP is a second messenger, used for intracellular signal transduction, such as transferring into cells the effects of hormones like glucagon and adrenaline, which cannot pass through the plasma membrane. It is involved in the activation of protein kinases and regulates the effects of adrenaline and glucagon. cAMP also binds to and regulates the function of ion channels such as the HCN channels and a few other cyclic nucleotide-binding proteins such as Epac1 and RAPGEF2.


Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of cAMP AM to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM249.209 µL1.246 mL2.492 mL12.46 mL24.921 mL
5 mM49.842 µL249.209 µL498.418 µL2.492 mL4.984 mL
10 mM24.921 µL124.604 µL249.209 µL1.246 mL2.492 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)Molecular weightVolume (Calculate)Concentration (Calculate)Moles



View all 115 references: Citation Explorer
Mechanisms of hydrogen sulfide (H2S) action on synaptic transmission at the mouse neuromuscular junction
Authors: Gerasimova E, Lebedeva J, Yakovlev A, Zefirov A, Giniatullin R, Sitdikova G.
Journal: Neuroscience (2015): 577
Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic beta-Cells
Authors: Shang J, Li J, Keller MP, Hohmeier HE, Wang Y, Feng Y, Zhou HH, Shen X, Rabaglia M, Soni M, Attie AD, Newgard CB, Thornberry NA, Howard AD, Zhou YP.
Journal: Mol Endocrinol (2015): 1243
Store-operated cAMP signaling contributes to Ca2+-activated Cl- secretion in T84 colonic cells
Authors: Nichols JM, Maiellaro I, Abi-Jaoude J, Curci S, Hofer AM.
Journal: Am J Physiol Gastrointest Liver Physiol (2015): G670
Exchange protein directly activated by cAMP mediates slow delayed-rectifier current remodeling by sustained beta-adrenergic activation in guinea pig hearts
Authors: Aflaki M, Qi XY, Xiao L, Ordog B, Tadevosyan A, Luo X, Maguy A, Shi Y, Tardif JC, Nattel S.
Journal: Circ Res (2014): 993
The nephrotoxic Ifosfamide-metabolite chloroacetaldehyde interferes with renal extracellular matrix homeostasis
Authors: Benesic A, Schwerdt G, Hennemeier I, Sauvant C, Mildenberger S, Gekle M.
Journal: Cell Physiol Biochem (2014): 1106
The secretogranin II gene is a signal integrator of glutamate and dopamine inputs
Authors: Iwase K, Ishihara A, Yoshimura S, Andoh Y, Kato M, Seki N, Matsumoto E, Hiwasa T, Muller D, Fukunaga K, Takiguchi M.
Journal: J Neurochem (2014): 233
Serotonin triggers cAMP and PKA-mediated intracellular calcium waves in Malpighian tubules of Rhodnius prolixus
Authors: Gioino P, Murray BG, Ianowski JP.
Journal: Am J Physiol Regul Integr Comp Physiol (2014): R828
Prostaglandin E2 induces chloride secretion through crosstalk between cAMP and calcium signaling in mouse inner medullary collecting duct cells
Authors: Rajagopal M, Thomas SV, Kathpalia PP, Chen Y, Pao AC.
Journal: Am J Physiol Cell Physiol (2014): C263
Exchange protein activated by cAMP (Epac) induces vascular relaxation by activating Ca2+-sensitive K+ channels in rat mesenteric artery
Authors: Roberts OL, Kamishima T, Barrett-Jolley R, Quayle JM, Dart C.
Journal: J Physiol (2013): 5107
Involvement of PKA-dependent upregulation of nNOS-CGRP in adrenomedullin-initiated mechanistic pathway underlying CFA-induced response in rats
Authors: Wang D, Ruan L, Hong Y, Chabot JG, Quirion R.
Journal: Exp Neurol (2013): 111