cAMP AM | AAT Bioquest

cAMP AM

cAMP-AM is the cell-permeant cAMP. After permeation and metabolic activation by esterases the polar cAMP is released which is trapped inside the cell and subsequently metabolized quickly, resulting in a pulse-type signal. cAMP is a second messenger, used for intracellular signal transduction, such as transferring into cells the effects of hormones like glucagon and adrenaline, which cannot pass through the plasma membrane. It is involved in the activation of protein kinases and regulates the effects of adrenaline and glucagon. cAMP also binds to and regulates the function of ion channels such as the HCN channels and a few other cyclic nucleotide-binding proteins such as Epac1 and RAPGEF2.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
20300	1 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of cAMP AM to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	249.209 µL	1.246 mL	2.492 mL	12.46 mL	24.921 mL
5 mM	49.842 µL	249.209 µL	498.418 µL	2.492 mL	4.984 mL
10 mM	24.921 µL	124.604 µL	249.209 µL	1.246 mL	2.492 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	401.27 g/mol	=	mL	x	mM	=	mmol

References

View all 115 references: Citation Explorer

Mechanisms of hydrogen sulfide (H2S) action on synaptic transmission at the mouse neuromuscular junction

Authors:

Gerasimova E, Lebedeva J, Yakovlev A, Zefirov A, Giniatullin R, Sitdikova G.

Journal:

Neuroscience (2015): 577

Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic beta-Cells

Authors:

Shang J, Li J, Keller MP, Hohmeier HE, Wang Y, Feng Y, Zhou HH, Shen X, Rabaglia M, Soni M, Attie AD, Newgard CB, Thornberry NA, Howard AD, Zhou YP.

Journal:

Mol Endocrinol (2015): 1243

Store-operated cAMP signaling contributes to Ca2+-activated Cl- secretion in T84 colonic cells

Authors:

Nichols JM, Maiellaro I, Abi-Jaoude J, Curci S, Hofer AM.

Journal:

Am J Physiol Gastrointest Liver Physiol (2015): G670

Exchange protein directly activated by cAMP mediates slow delayed-rectifier current remodeling by sustained beta-adrenergic activation in guinea pig hearts

Authors:

Aflaki M, Qi XY, Xiao L, Ordog B, Tadevosyan A, Luo X, Maguy A, Shi Y, Tardif JC, Nattel S.

Journal:

Circ Res (2014): 993

The nephrotoxic Ifosfamide-metabolite chloroacetaldehyde interferes with renal extracellular matrix homeostasis

Authors:

Benesic A, Schwerdt G, Hennemeier I, Sauvant C, Mildenberger S, Gekle M.

Journal:

Cell Physiol Biochem (2014): 1106

Physical properties

Molecular weight	401.27
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12352200

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Page updated on July 26, 2023