Name: CDPI3 Alkyne [Minor Groove Binder Alkyne]
Brand: AAT Bioquest
SKU: 6910
Price: 221 USD
Availability: InStock

CDPI3 Alkyne

Minor Groove Binder Alkyne

Minor Groove Binder (MGB) molecules selectively bind to the minor groove of a DNA molecule, the shallow furrow in the DNA helix. MGB-labeled oligonucleotides form stable hybrid complexes with complementary DNA and RNA target sequences. Dihydropyrroloindole tripeptide (CDPI3), the analogs of natural product CC-1065, have been shown to arrest sequence-specific primer extension on single-stranded DNA when linked to oligonucleotides. CDPI3-containing oligonucleotides increases both the specificity and the strength of hybridization, thus enhancing the stability of DNA duplexes. The addition of MGB molecules to DNA probes allows the design of shorter hybridization probes useful for molecular diagnostics, e.g., quantitative PCR based assays. Several designs are possible, including Taqman MGB probes. Compared to other commercial MGB probes, AAT Bioquest offer this MGB building block that contains a methylpiperazine moiety (derived from Hoechst 33258, another popular MGB molecule) to further enhance its DNA affinity. We offer CDPI3 alkyne for labeling azide-modified oligos.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
6910	1 mg	Price

References

View all 50 references: Citation Explorer

Mammalian DNA Polymerase Kappa Activity and Specificity.

Authors:

Stern, Hannah R and Sefcikova, Jana and Chaparro, Victoria E and Beuning, Penny J

Journal:

Molecules (Basel, Switzerland) (2019)

Canonical DNA minor groove insertion of bisbenzamidine-Ru(ii) complexes with chiral selectivity.

Authors:

Sánchez, Mateo I and Rama, Gustavo and Calo-Lapido, Renata and Ucar, Kübra and Lincoln, Per and López, Miguel Vázquez and Melle-Franco, Manuel and Mascareñas, José L and Vázquez, M Eugenio

Journal:

Chemical science (2019): 8668-8674

Synthesis of N2 -Aryl-2'-Deoxyguanosine Modified Phosphoramidites and Oligonucleotides.

Authors:

Ghodke, Pratibha P and Pradeepkumar, P I

Journal:

Current protocols in nucleic acid chemistry (2019): e93

Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model.

Authors:

Depauw, Sabine and Lambert, Mélanie and Jambon, Samy and Paul, Ananya and Peixoto, Paul and Nhili, Raja and Marongiu, Laura and Figeac, Martin and Dassi, Christelle and Paul-Constant, Charles and Billoré, Benjamin and Kumar, Arvind and Farahat, Abdelbasset A and Ismail, Mohamed A and Mineva, Ekaterina and Sweat, Daniel P and Stephens, Chad E and Boykin, David W and Wilson, W David and David-Cordonnier, Marie-Hélène

Journal:

Journal of medicinal chemistry (2019): 1306-1329

Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct.

Authors:

Yoon, Jung-Hoon and Hodge, Richard P and Hackfeld, Linda C and Park, Jeseong and Roy Choudhury, Jayati and Prakash, Satya and Prakash, Louise

Journal:

The Journal of biological chemistry (2018): 2949-2958

Physical properties

Molecular weight	1403.64
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501

Documents

Protocol
Safety Data Sheet
Certificate of Analysis

Telephone
Fax
Email	sales@aatbio.com
International	See distributors
Bulk request	Inquire
Custom size	Inquire
Technical Support	Contact us
Request quotation	Request
Purchase order	Send to sales@aatbio.com
Shipping	Standard overnight for United States, inquire for international

Page updated on October 18, 2025