AAT Bioquest

CDPI3-CPG [Minor Groove Binder CPG] *1000A*

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H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure


Minor Groove Binder (MGB) molecules selectively bind to the minor groove of a DNA molecule, the shallow furrow in the DNA helix. MGB-labeled oligonucleotides form stable hybrid complexes with complementary DNA and RNA target sequences. Dihydropyrroloindole tripeptide (CDPI3), the analogs of natural product CC-1065, have been shown to arrest sequence-specific primer extension on single-stranded DNA when linked to oligonucleotides. CDPI3-containing oligonucleotides increases both the specificity and the strength of hybridization, thus enhancing the stability of DNA duplexes. The addition of MGB molecules to DNA probes allows the design of shorter hybridization probes useful for molecular diagnostics, e.g., quantitative PCR based assays. Several designs are possible, including Taqman MGB probes. AAT Bioquest offer this CPG support for conveniently adding an MGB moiety to the 3’-terminals of oligos. We also offer MGB phosphoramidite for labeling 5' terminus with an MGB moiety.



View all 4 references: Citation Explorer
The preferential binding of histone H1 to DNA scaffold-associated regions is determined by its C-terminal domain.
Authors: Roque, Alicia and Orrego, Mary and Ponte, Imma and Suau, Pedro
Journal: Nucleic acids research (2004): 6111-9
Oligonucleotide-minor groove binder conjugates and their complexes with complementary DNA: effect of conjugate structural factors on the thermal stability of duplexes.
Authors: Ryabinin, Vladimir A and Boutorine, Alexandre S and Hélène, Claude and Pyshnyi, Dmitrii V and Sinyakov, Alexandre N
Journal: Nucleosides, nucleotides & nucleic acids (2004): 789-803
Synthesis and evaluation of oligo-1,3-thiazolecarboxamide derivatives as HIV-1 reverse transcriptase inhibitors.
Authors: Ryabinin, V A and Zakharova, O D and Yurchenko, E Y and Timofeeva, O A and Martyanov, I V and Tokarev, A A and Belanov, E F and Bormotov, N I and Tarrago-Litvak, L and Andreola, M L and Litvak, S and Nevinsky, G A and Sinyakov, A N
Journal: Bioorganic & medicinal chemistry (2000): 985-93
[Effect of structural factors on the stability of duplexes formed by oligonucleotide conjugates with minor groove ligands].
Authors: Riabinin, V A and Butorin, A S and Elen, K and Denisov, A Iu and Pyshnyĭ, D V and Siniakov, A N
Journal: Bioorganicheskaia khimiia : 159-66