CDPI3-CPG [Minor Groove Binder CPG] *500A*
Ordering information
Price | |
Catalog Number | |
Unit Size | |
Quantity |
Additional ordering information
Telephone | 1-800-990-8053 |
Fax | 1-800-609-2943 |
sales@aatbio.com | |
International | See distributors |
Bulk request | Inquire |
Custom size | Inquire |
Shipping | Standard overnight for United States, inquire for international |
Physical properties
Molecular weight | N/A |
Solvent | MeCN |
Storage, safety and handling
H-phrase | H303, H313, H333 |
Hazard symbol | XN |
Intended use | Research Use Only (RUO) |
R-phrase | R20, R21, R22 |
Storage | Freeze (< -15 °C); Minimize light exposure |
UNSPSC | 12171501 |
Alternative formats
CDPI3-CPG [Minor Groove Binder CPG] *1000A* |
Overview | SDSProtocol |
Molecular weight N/A |
Minor Groove Binder (MGB) molecules selectively bind to the minor groove of a DNA molecule, the shallow furrow in the DNA helix. MGB-labeled oligonucleotides form stable hybrid complexes with complementary DNA and RNA target sequences. Dihydropyrroloindole tripeptide (CDPI3), the analogs of natural product CC-1065, have been shown to arrest sequence-specific primer extension on single-stranded DNA when linked to oligonucleotides. CDPI3-containing oligonucleotides increases both the specificity and the strength of hybridization, thus enhancing the stability of DNA duplexes. The addition of MGB molecules to DNA probes allows the design of shorter hybridization probes useful for molecular diagnostics, e.g., quantitative PCR based assays. Several designs are possible, including Taqman MGB probes. AAT Bioquest offer this CPG support for conveniently adding an MGB moiety to the 3’-terminals of oligos. We also offer MGB phosphoramidite for labeling 5' terminus with an MGB moiety.
References
View all 50 references: Citation Explorer
Capecitabine as a minor groove binder of DNA: molecular docking, molecular dynamics, and multi-spectroscopic studies.
Authors: Zhang, Shuangshuang and Yang, Hongqin and Zhao, Ludan and Gan, Ruixue and Tang, Peixiao and Sun, Qiaomei and Xiong, Xinnuo and Li, Hui
Journal: Journal of biomolecular structure & dynamics (2019): 1451-1463
Authors: Zhang, Shuangshuang and Yang, Hongqin and Zhao, Ludan and Gan, Ruixue and Tang, Peixiao and Sun, Qiaomei and Xiong, Xinnuo and Li, Hui
Journal: Journal of biomolecular structure & dynamics (2019): 1451-1463
Minor groove binder modification of widely used TaqMan hydrolysis probe for detection of dengue virus reduces risk of false-negative real-time PCR results for serotype 4.
Authors: Gray, Eleanor R and Heaney, Judith and Ferns, R Bridget and Sequeira, Patricia C and Nastouli, Eleni and Garson, Jeremy A
Journal: Journal of virological methods (2019): 17-23
Authors: Gray, Eleanor R and Heaney, Judith and Ferns, R Bridget and Sequeira, Patricia C and Nastouli, Eleni and Garson, Jeremy A
Journal: Journal of virological methods (2019): 17-23
A rapid minor groove binder PCR method for distinguishing the vaccine strain Brucella abortus 104M.
Authors: Nan, Wenlong and Qin, Lide and Wang, Yong and Zhang, Yueyong and Tan, Pengfei and Chen, Yuqi and Mao, Kairong and Chen, Yiping
Journal: BMC veterinary research (2018): 27
Authors: Nan, Wenlong and Qin, Lide and Wang, Yong and Zhang, Yueyong and Tan, Pengfei and Chen, Yuqi and Mao, Kairong and Chen, Yiping
Journal: BMC veterinary research (2018): 27
Influence of Divalent Counterions on the Dynamics in DNA as Probed by Using a Minor-Groove Binder.
Authors: Paul, Sneha and Ahmed, Tasnim and Samanta, Anunay
Journal: Chemphyschem : a European journal of chemical physics and physical chemistry (2017): 2058-2064
Authors: Paul, Sneha and Ahmed, Tasnim and Samanta, Anunay
Journal: Chemphyschem : a European journal of chemical physics and physical chemistry (2017): 2058-2064
Origin of DNA-Induced Circular Dichroism in a Minor-Groove Binder.
Authors: Holmgaard List, Nanna and Knoops, Jérémie and Rubio-Magnieto, Jenifer and Idé, Julien and Beljonne, David and Norman, Patrick and Surin, Mathieu and Linares, Mathieu
Journal: Journal of the American Chemical Society (2017): 14947-14953
Authors: Holmgaard List, Nanna and Knoops, Jérémie and Rubio-Magnieto, Jenifer and Idé, Julien and Beljonne, David and Norman, Patrick and Surin, Mathieu and Linares, Mathieu
Journal: Journal of the American Chemical Society (2017): 14947-14953
Development of a real-time quantitative PCR assay using a TaqMan minor groove binder probe for the detection of α-lactalbumin in food.
Authors: Xiao, Guan and Qin, Cai and Wenju, Zhang and Qin, Chen
Journal: Journal of dairy science (2016): 1716-1724
Authors: Xiao, Guan and Qin, Cai and Wenju, Zhang and Qin, Chen
Journal: Journal of dairy science (2016): 1716-1724
Synthesis of a novel 4H-pyran analog as minor groove binder to DNA using ethidium bromide as fluorescence probe.
Authors: Ramana, M M V and Betkar, Rahul and Nimkar, Amey and Ranade, Prasanna and Mundhe, Balaji and Pardeshi, Sachin
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2016): 165-71
Authors: Ramana, M M V and Betkar, Rahul and Nimkar, Amey and Ranade, Prasanna and Mundhe, Balaji and Pardeshi, Sachin
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2016): 165-71
Grandivittin as a natural minor groove binder extracted from Ferulago macrocarpa to ct-DNA, experimental and in silico analysis.
Authors: Ahmadi, F and Valadbeigi, S and Sajjadi, S E and Shokoohinia, Y and Azizian, H and Taheripak, G
Journal: Chemico-biological interactions (2016): 89-101
Authors: Ahmadi, F and Valadbeigi, S and Sajjadi, S E and Shokoohinia, Y and Azizian, H and Taheripak, G
Journal: Chemico-biological interactions (2016): 89-101
Glycosaminoglycans are potential pharmacological targets for classic DNA minor groove binder drugs berenil and pentamidine.
Authors: Zsila, Ferenc
Journal: Physical chemistry chemical physics : PCCP (2015): 24560-5
Authors: Zsila, Ferenc
Journal: Physical chemistry chemical physics : PCCP (2015): 24560-5
Dacarbazine as a minor groove binder of DNA: Spectroscopic, biophysical and molecular docking studies.
Authors: Ahmad, Irshad and Ahmad, Masood
Journal: International journal of biological macromolecules (2015): 193-200
Authors: Ahmad, Irshad and Ahmad, Masood
Journal: International journal of biological macromolecules (2015): 193-200