Chrysamine G *CAS 6472-91-9*

Chrysamine G

CAS 6472-91-9

Chrysamine G is a lipophilic, bis-salicylic acid analog of Congo Red that displays both high (Kd = 200 nM; Bmax = 1.13 moles per mole of Ab40) and low (Kd = 38.77 µM; Bmax = 23.10 moles per mole of Ab40) affinity binding sites for beta-amyloid (Ab) fibrils. It can cross the blood-brain barrier and serve as a useful probe for detecting senile plaques (Ab aggregate).

Protocol

SDS

COA

Catalog	Size	Price	Quantity
23055	5 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Chrysamine G *CAS 6472-91-9* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	207.28 µL	1.036 mL	2.073 mL	10.364 mL	20.728 mL
5 mM	41.456 µL	207.28 µL	414.559 µL	2.073 mL	4.146 mL
10 mM	20.728 µL	103.64 µL	207.28 µL	1.036 mL	2.073 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	482.44 g/mol	=	mL	x	mM	=	mmol

References

View all 13 references: Citation Explorer

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo

Authors:

Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM.

Journal:

J Biol Chem (2005): 5892

Imaging beta-amyloid plaques and neurofibrillary tangles in the aging human brain

Authors:

Mathis CA, Wang Y, Klunk WE.

Journal:

Curr Pharm Des (2004): 1469

Amyloid binding ligands as Alzheimer's disease therapies

Authors:

Lee VM., undefined

Journal:

Neurobiol Aging (2002): 1039

Chrysamine G and its derivative reduce amyloid beta-induced neurotoxicity in mice

Authors:

Ishii K, Klunk WE, Arawaka S, Debnath ML, Furiya Y, Sahara N, Shoji S, Tamaoka A, Pettegrew JW, Mori H.

Journal:

Neurosci Lett (2002): 5

Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative

Authors:

Klunk WE, Bacskai BJ, Mathis CA, Kajdasz ST, McLellan ME, Frosch MP, Debnath ML, Holt DP, Wang Y, Hyman BT.

Journal:

J Neuropathol Exp Neurol (2002): 797

Physical properties

Molecular weight	482.44
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12352200
CAS	6472-91-9

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Page updated on October 13, 2025