cOVA *Optimized for Maximum Immunization Response*

cOVA

Optimized for Maximum Immunization Response

cOVA is the ovalbumin (OVA) modified with ethylenediamine to make the proteins bear more amine groups (thus more positive charges at neutral pH). It is proven to be a superior carrier protein for developing antibodies since cOVA conjugates have stronger imunological responses than the unmodifed OVA cinjugates.

Rabbits are immunized with BSA, BSA-AHD (Aminohydantoin), cBSA-AHD and hBSA-AHD conjugates. Antisera from immunized rabbits are tested for the immune response against AHD.   Data indicate  cBSA-AHD and hBSA-AHD exhibit a stronger immune response to AHD in comparison with BSA-AHD. Similar results are obtained for cOval and hOval conjugates (Mol Pharm. 2011 August 1; 8(4): 1174–1185).

Protocol

SDS

COA

Catalog	Size	Price	Quantity
5605	10 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of appropriate solvent needed to reconstitute specific mass of cOVA *Optimized for Maximum Immunization Response* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	1.667 µL	8.333 µL	16.667 µL	83.333 µL	166.667 µL
5 mM	333.333 nL	1.667 µL	3.333 µL	16.667 µL	33.333 µL
10 mM	166.667 nL	833.333 nL	1.667 µL	8.333 µL	16.667 µL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	60000 g/mol	=	mL	x	mM	=	mmol

References

View all 29 references: Citation Explorer

Optimization of the preparation process of vinblastine sulfate (VBLS)-loaded folate-conjugated bovine serum albumin (BSA) nanoparticles for tumor-targeted drug delivery using response surface methodology (RSM)

Authors:

Zu Y, Zhang Y, Zhao X, Zhang Q, Liu Y, Jiang R.

Journal:

Int J Nanomedicine (2009): 321

Characterization of bovine serum albumin glycated with glucose, galactose and lactose

Authors:

Ledesma-Osuna AI, Ramos-Clamont G, Vazquez-Moreno L.

Journal:

Acta Biochim Pol (2008): 491

Improvement of functional properties of bovine serum albumin through phosphorylation by dry-heating in the presence of pyrophosphate

Authors:

Enomoto H, Li CP, Morizane K, Ibrahim HR, Sugimoto Y, Ohki S, Ohtomo H, Aoki T.

Journal:

J Food Sci (2008): C84

Polyethylene glycol improves conjugation of bovine hemoglobin and human serum albumin in a controlled ratio

Authors:

Zheng C, Bi J, Ma G, Su Z.

Journal:

Artif Cells Blood Substit Immobil Biotechnol (2007): 568

Purification of denatured bovine serum albumin coated CdTe quantum dots for sensitive detection of silver(I) ions

Authors:

Wang JH, Wang HQ, Zhang HL, Li XQ, Hua XF, Cao YC, Huang ZL, Zhao YD.

Journal:

Anal Bioanal Chem (2007): 969

Physical properties

Molecular weight

60000

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C)
UNSPSC	12352200

Telephone
Fax
Email	sales@aatbio.com
International	See distributors
Bulk request	Inquire
Custom size	Inquire
Technical Support	Contact us
Request quotation	Request
Purchase order	Send to sales@aatbio.com
Shipping	Standard overnight for United States, inquire for international

Page updated on October 12, 2025