Cyluc1 [(4S)-2-(6,7-Dihydro-5H-thiazolo[4,5-f]indol-2-yl)-4,5-dihydro-thiazole-4-carboxylic acid]

Cyluc1

(4S)-2-(6,7-Dihydro-5H-thiazolo[4,5-f]indol-2-yl)-4,5-dihydro-thiazole-4-carboxylic acid

Cyluc1 is a synthetic cyclic alkylaminoluciferin that exhibits properties that are superior to those of D-luciferin for in vivo imaging due to its red-shifted luminescence. It binds to luciferase with higher affinity and and emits about 5.7-fold more light than aminoluciferin and 3.2-fold more light than D-luciferin. Its superior light output is maintained over a wide range (1-100 µM). It has been demonstrated that Cyluc1 readily crosses the blood-brain barrier in mice and provides much improved noninvasive bioluminescence imaging (BLI) of the brain at lower dose when compared to D-luciferin. It yields about 10-fold higher bioluminescent signal than D-luciferin when Luc2 luciferase expressing 4T1 breast cancer cells are implanted into the mammary fat pads of BABL/c mice. A rapid (4-5 min), long-lasting, and steady signal peak is observed following an i.v injection CycLuc1 in mice.

Protocol

COA

Catalog	Size	Price
12480	5 mg	Price
12481	25 mg	Price
12482	100 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Cyluc1 [(4S)-2-(6,7-Dihydro-5H-thiazolo[4,5-f]indol-2-yl)-4,5-dihydro-thiazole-4-carboxylic acid] to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	327.472 µL	1.637 mL	3.275 mL	16.374 mL	32.747 mL
5 mM	65.494 µL	327.472 µL	654.943 µL	3.275 mL	6.549 mL
10 mM	32.747 µL	163.736 µL	327.472 µL	1.637 mL	3.275 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	305.37 g/mol	=	mL	x	mM	=	mmol

Physical properties

Molecular weight	305.37
Solvent	DMSO

Spectral properties

Correction factor (260 nm)	0.218
Correction factor (280 nm)	0.312
Extinction coefficient (cm ^-1 M ^-1)	18231
Excitation (nm)	362
Emission (nm)	542

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	41105331
CAS	1247879-16-8

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Page updated on October 12, 2025