Name: DBCO PEG4 Amine
Brand: AAT Bioquest
SKU: 4534
Price: 128 USD
Availability: InStock

DBCO PEG4 Amine

DBCO-PEG4-amine is a bifunctional reagent containing a copper-free click chemistry DBCO group and a primary amine separated by a hydrophilic PEG4 spacer, enabling strain-promoted azide-alkyne cycloaddition under biocompatible conditions.

Bifunctional Click Reagent: Combines DBCO for azide reactions with primary amine for further conjugation
PEG4 Hydrophilic Spacer: Increases solubility and reduces non-specific binding in biological systems
Bioorthogonal Chemistry: Selectively reacts with azides without interfering with native biomolecules
Live-Cell Compatible: Enables labeling in physiological conditions without toxicity

Protocol

SDS

COA

Catalog	Size	Price	Quantity
4534	25 mg	Price

Overview

DBCO (dibenzocyclooctyne) PEG4 Amine is an excellent building block for developing DBCO-based labeling probes. The PEG4 arm significantly increases the compound's hydrophilicity. DBCO reagent is a common class of copper-free click chemistry labeling reagents. They exclusively react with azide-tagged biomolecules. The DBCO click chemistry is one of the most common strain-promoted alkyne azide cycloadditions (SPAAC). Early click chemistry reactions required copper as a catalyst. Copper is cytotoxic and thus limits the application of click reactions in cells and other biological samples. The SPAAC of DBCO eliminates the cytotoxicity problem caused by copper. The DBCO click reactions are bio-orthogonal, i.e. they can occur within organisms without interfering with native biochemical processes, and are now widely used in bioconjugation, labeling and chemical biology.

References

View all 50 references: Citation Explorer

Designable Nanoadaptor for Enhanced Recognition of Natural Killer Cell to Tumor via Bio-orthogonal Click Reaction.

Authors:

Yang, Xiaohu and Yang, Hongchao and Li, Tuanwei and Ling, Sisi and Li, Meng and Zhang, Yejun and Wu, Feng and Liu, Shaoqin and Li, Chunyan and Wang, Qiangbin

Journal:

Nano letters (2024): 7698-7705

Integrating Metabolic Oligosaccharide Engineering and SPAAC Click Chemistry for Constructing Fibrinolytic Cell Surfaces.

Authors:

Liu, Shengjie and Yang, He and Heng, Xingyu and Yao, Lihua and Sun, Wei and Zheng, Qing and Wu, Zhaoqiang and Chen, Hong

Journal:

ACS applied materials & interfaces (2024): 35874-35886

Click Chemistry-Mediated Polymannose Surface-Engineering of Natural Killer Cells for Immunotherapy of Triple-Negative Breast Cancer.

Authors:

Niu, Xiaomeng and Yang, He and Guo, Jiangping and Yao, Lihua and Wang, Yichen and Yu, Wenzhuo and Liu, Zhuang and Chen, Hong

Journal:

Advanced healthcare materials (2024): e2400970

Click-Chemistry-Mediated Cell Membrane Glycopolymer Engineering to Potentiate Dendritic Cell Vaccines.

Authors:

Yang, He and Xiong, Zijian and Heng, Xingyu and Niu, Xiaomeng and Wang, Yichen and Yao, Lihua and Sun, Lele and Liu, Zhuang and Chen, Hong

Journal:

Angewandte Chemie (International ed. in English) (2024): e202315782

Bioorthogonal "Click and Release" Reaction-Triggered Aggregation of Gold Nanoparticles Combined with Released Lonidamine for Enhanced Cancer Photothermal Therapy.

Authors:

Yan, Xiao and Li, Ke and Xie, Tian-Qiu and Jin, Xiao-Kang and Zhang, Cheng and Li, Qian-Ru and Feng, Jun and Liu, Chuan-Jun and Zhang, Xian-Zheng

Journal:

Angewandte Chemie (International ed. in English) (2024): e202318539

Physical properties

Molecular weight	523.63
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
CAS	1255942-08-5

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Page updated on September 28, 2025