Deoxycholic acid-iFluor® 647 conjugate
Ordering information
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Additional ordering information
Telephone | 1-800-990-8053 |
Fax | 1-800-609-2943 |
sales@aatbio.com | |
International | See distributors |
Bulk request | Inquire |
Custom size | Inquire |
Shipping | Standard overnight for United States, inquire for international |
Physical properties
Molecular weight | 1253.63 |
Solvent | DMSO |
Spectral properties
Correction Factor (260 nm) | 0.03 |
Correction Factor (280 nm) | 0.03 |
Correction Factor (656 nm) | 0.0793 |
Extinction coefficient (cm -1 M -1) | 2500001 |
Excitation (nm) | 656 |
Emission (nm) | 670 |
Quantum yield | 0.251 |
Storage, safety and handling
H-phrase | H303, H313, H333 |
Hazard symbol | XN |
Intended use | Research Use Only (RUO) |
R-phrase | R20, R21, R22 |
Storage | Freeze (< -15 °C); Minimize light exposure |
UNSPSC | 12171501 |
Overview | SDSProtocol |
See also: iFluor® Dyes and Kits
Molecular weight 1253.63 | Correction Factor (260 nm) 0.03 | Correction Factor (280 nm) 0.03 | Correction Factor (656 nm) 0.0793 | Extinction coefficient (cm -1 M -1) 2500001 | Excitation (nm) 656 | Emission (nm) 670 | Quantum yield 0.251 |
Deoxycholic acid, also known as cholanoic acid is a bile acid. Deoxycholic acid-iFluor® 647 conjugate is a red fluorescent derivative of deoxycholic acid. It is an iFluor® 647-labeled bile acid derivative that closely parallels the cellular binding and uptake properties of deoxycholic acid. It is a divalent 'unipolar' anionic fluorescent bile salt analog that might offer a potentially useful probe for studying cellular mechanisms of deoxycholic acid at the hepatocellular level. Deoxycholic acid-iFluor® 647 conjugate can be used as a tool for the visualization of bile acid transport for the samples that have either strong blue or green fluorescence since its strong red fluorescence is well separated from blue or green fluorescence. Deoxycholic acid is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. The two primary bile acids secreted by the liver are cholic acid and chenodeoxycholic acid. Deoxycholic acid, under the brand name Kybella, is approved by the FDA for reducing moderate-to-severe fat below the chin. When injected into submental fat, deoxycholic acid helps destroy fat cells.
Calculators
Common stock solution preparation
Table 1. Volume of DMSO needed to reconstitute specific mass of Deoxycholic acid-iFluor® 647 conjugate to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
1 mM | 79.768 µL | 398.842 µL | 797.684 µL | 3.988 mL | 7.977 mL |
5 mM | 15.954 µL | 79.768 µL | 159.537 µL | 797.684 µL | 1.595 mL |
10 mM | 7.977 µL | 39.884 µL | 79.768 µL | 398.842 µL | 797.684 µL |
Molarity calculator
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Spectrum
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Spectral properties
Correction Factor (260 nm) | 0.03 |
Correction Factor (280 nm) | 0.03 |
Correction Factor (656 nm) | 0.0793 |
Extinction coefficient (cm -1 M -1) | 2500001 |
Excitation (nm) | 656 |
Emission (nm) | 670 |
Quantum yield | 0.251 |
References
View all 50 references: Citation Explorer
Effective oral delivery of Exenatide-Zn2+ complex through distal ileum-targeted double layers nanocarriers modified with deoxycholic acid and glycocholic acid in diabetes therapy.
Authors: Han, Ying and Liu, Wei and Chen, Liqing and Xin, Xin and Wang, Qiming and Zhang, Xintong and Jin, Mingji and Gao, Zhonggao and Huang, Wei
Journal: Biomaterials (2021): 120944
Authors: Han, Ying and Liu, Wei and Chen, Liqing and Xin, Xin and Wang, Qiming and Zhang, Xintong and Jin, Mingji and Gao, Zhonggao and Huang, Wei
Journal: Biomaterials (2021): 120944
Evaluating a Topical Adjunctive Post Submental ATX-101 (Deoxycholic Acid) Injections for Improved Recovery: A Single-Center, Double-Blind, Randomized Controlled Pilot Study.
Authors: Shridharani, Sachin M
Journal: Aesthetic surgery journal. Open forum (2021): ojab028
Authors: Shridharani, Sachin M
Journal: Aesthetic surgery journal. Open forum (2021): ojab028
The integrity and barrier function of porcine vocal fold epithelium: its susceptibility to damage by deoxycholic acid compared with pepsin.
Authors: Lou, Zhewei and Gong, Ting and Zhang, Chi and Silverman, Matthew and Li, Xiaxia and Lin, Zhihong and Jiang, Jack J
Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies ( (2021)
Authors: Lou, Zhewei and Gong, Ting and Zhang, Chi and Silverman, Matthew and Li, Xiaxia and Lin, Zhihong and Jiang, Jack J
Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies ( (2021)
Deoxycholic acid induces proinflammatory cytokine production by model oesophageal cells via lipid rafts.
Authors: Quilty, Francis and Freeley, Michael and Gargan, Siobhan and Gilmer, John and Long, Aideen
Journal: The Journal of steroid biochemistry and molecular biology (2021): 105987
Authors: Quilty, Francis and Freeley, Michael and Gargan, Siobhan and Gilmer, John and Long, Aideen
Journal: The Journal of steroid biochemistry and molecular biology (2021): 105987
Deoxycholic Acid Upregulates Serum Golgi Protein 73 through Activating NF-κB Pathway and Destroying Golgi Structure in Liver Disease.
Authors: Yang, Danli and Yao, Mingjie and Yan, Ying and Liu, Yanna and Wen, Xiajie and Chen, Xiangmei and Lu, Fengmin
Journal: Biomolecules (2021)
Authors: Yang, Danli and Yao, Mingjie and Yan, Ying and Liu, Yanna and Wen, Xiajie and Chen, Xiangmei and Lu, Fengmin
Journal: Biomolecules (2021)
Safety and Efficacy of Deoxycholic Acid Injection for Hypogastric Fat Reduction: A Pilot Study.
Authors: Salvador, Laura and Benito-Ruiz, Jesús
Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (2021): e132-e137
Authors: Salvador, Laura and Benito-Ruiz, Jesús
Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (2021): e132-e137
The novel nanocomplexes containing deoxycholic acid-grafted chitosan and oleanolic acid displays the hepatoprotective effect against CCl4-induced liver injury in vivo.
Authors: Xin, Chao and Liu, Shuang and Qu, Hang and Wang, Zhenyu
Journal: International journal of biological macromolecules (2021): 338-349
Authors: Xin, Chao and Liu, Shuang and Qu, Hang and Wang, Zhenyu
Journal: International journal of biological macromolecules (2021): 338-349
Deoxycholic acid activates and sensitizes vagal nociceptive afferent C-fibers in guinea pig esophagus.
Authors: Yu, Xiaoyun and Hu, Youtian and Yu, Mingwei and Undem, Bradley J and Yu, Shaoyong
Journal: American journal of physiology. Gastrointestinal and liver physiology (2021): G149-G156
Authors: Yu, Xiaoyun and Hu, Youtian and Yu, Mingwei and Undem, Bradley J and Yu, Shaoyong
Journal: American journal of physiology. Gastrointestinal and liver physiology (2021): G149-G156
Hemolysis after subcutaneous deoxycholic acid overdose.
Authors: Sharpe, Abigail and O'Keefe, Mary and Windsor, Katie and Theobald, Jillian and Feldman, Ryan
Journal: The American journal of emergency medicine (2021)
Authors: Sharpe, Abigail and O'Keefe, Mary and Windsor, Katie and Theobald, Jillian and Feldman, Ryan
Journal: The American journal of emergency medicine (2021)
Self-assembly of dextran - b - deoxycholic acid polyester copolymers: Copolymer composition and self-assembly procedure tune the aggregate size and morphology.
Authors: Nichifor, Marieta and Stanciu, Magdalena Cristina and Doroftei, Florica
Journal: Carbohydrate polymers (2021): 117147
Authors: Nichifor, Marieta and Stanciu, Magdalena Cristina and Doroftei, Florica
Journal: Carbohydrate polymers (2021): 117147
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What is the difference between FluoroQuest Anti-fading Kit I and FluoroQuest Anti-fading Kit II?