Deoxycholic acid-iFluor® 647 conjugate
Deoxycholic acid, also known as cholanoic acid is a bile acid. Deoxycholic acid-iFluor® 647 conjugate is a red fluorescent derivative of deoxycholic acid. It is an iFluor® 647-labeled bile acid derivative that closely parallels the cellular binding and uptake properties of deoxycholic acid. It is a divalent 'unipolar' anionic fluorescent bile salt analog that might offer a potentially useful probe for studying cellular mechanisms of deoxycholic acid at the hepatocellular level. Deoxycholic acid-iFluor® 647 conjugate can be used as a tool for the visualization of bile acid transport for the samples that have either strong blue or green fluorescence since its strong red fluorescence is well separated from blue or green fluorescence. Deoxycholic acid is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. The two primary bile acids secreted by the liver are cholic acid and chenodeoxycholic acid. Deoxycholic acid, under the brand name Kybella, is approved by the FDA for reducing moderate-to-severe fat below the chin. When injected into submental fat, deoxycholic acid helps destroy fat cells.
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References
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Cationic nanoparticles self-assembled from amphiphilic chitosan derivatives containing poly(amidoamine) dendrons and deoxycholic acid as a vector for co-delivery of doxorubicin and gene.
Authors: Chen, Shanshan and Deng, Junjie and Zhang, Li-Ming
Journal: Carbohydrate polymers (2021): 117706
Authors: Chen, Shanshan and Deng, Junjie and Zhang, Li-Ming
Journal: Carbohydrate polymers (2021): 117706
Deoxycholic Acid and Lithocholic Acid Alleviate Liver Injury and Inflammation in Mice with Klebsiella pneumoniae-Induced Liver Abscess and Bacteremia.
Authors: Zheng, Yahong and Yue, Chengcheng and Zhang, Hui and Chen, Haoran and Liu, Yanyan and Li, Jiabin
Journal: Journal of inflammation research (2021): 777-789
Authors: Zheng, Yahong and Yue, Chengcheng and Zhang, Hui and Chen, Haoran and Liu, Yanyan and Li, Jiabin
Journal: Journal of inflammation research (2021): 777-789
Efficacy and safety of injectable deoxycholic acid for submental fat reduction: a systematic review and meta-analysis of randomized controlled trials.
Authors: Cunha, Karin Soares and Lima, Flávia and Cardoso, Roberta Marques
Journal: Expert review of clinical pharmacology (2021): 383-397
Authors: Cunha, Karin Soares and Lima, Flávia and Cardoso, Roberta Marques
Journal: Expert review of clinical pharmacology (2021): 383-397
Free Deoxycholic Acid Exacerbates Vascular Calcification in CKD through ER Stress-Mediated ATF4 Activation.
Authors: Miyazaki-Anzai, Shinobu and Masuda, Masashi and Shiozaki, Yuji and Keenan, Audrey L and Chonchol, Michel and Kremoser, Claus and Miyazaki, Makoto
Journal: Kidney360 (2021): 857-868
Authors: Miyazaki-Anzai, Shinobu and Masuda, Masashi and Shiozaki, Yuji and Keenan, Audrey L and Chonchol, Michel and Kremoser, Claus and Miyazaki, Makoto
Journal: Kidney360 (2021): 857-868
pH-sensitive chitosan-deoxycholic acid/alginate nanoparticles for oral insulin delivery.
Authors: Zhang, Ya-Wen and Tu, Ling-Lan and Tang, Zhan and Wang, Qiao and Zheng, Gao-Li and Yin, Li-Na
Journal: Pharmaceutical development and technology (2021): 1-10
Authors: Zhang, Ya-Wen and Tu, Ling-Lan and Tang, Zhan and Wang, Qiao and Zheng, Gao-Li and Yin, Li-Na
Journal: Pharmaceutical development and technology (2021): 1-10
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