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Di-4-ANBDQBS
JPW6033
Di-4-ANEPPS is considered a "gold standard" of optical mapping membrane potentials. However, its short wavelength, higher internalization rate and small fluorescence change limit its use in some biological samples. Di-4-ANBDQPQ and Di-4-ANBDQBS demonstrated 50-100% deltaF/F signal enhancement than di-4-ANEPPS in Tyrode's perfused ventricular wall preparations. The longer excitation wavelength of Di-4-ANBDQPQ and Di-4-ANBDQBS is well separated from the absorption maximum of blood (~580 nm), conveying a major advantage in blood-perfused preparations. Di-4-ANBDQPQ and Di-4ANBDQBS increase the depth of imaging of electrical activity in tissues, and facilitate imaging during blood perfusion. These two dyes are also useful in conventional epicardial mapping applications. In summary, Di-4-ANBDQPQ and Di-4ANBDQBS have greater ?F/F, slower internalization rate and easy cell loading. Moreover, the red shift of excitation and emission is likely to be another useful feature. These dyes may as well be useful for optical mapping of monolayers and individual cardiac myocytes, given the ability of these dyes to respond to low levels of illumination (1 mW/mm2) and high deltaF/F. Monolayers and individual cardiac myocytes usually require high intensities of illumination, which often results in photobleaching.
Chemical structure for Di-4-ANBDQBS  [JPW6033]
Chemical structure for Di-4-ANBDQBS  [JPW6033]
CatalogSize
Price
Quantity
215001 mg
Price
 
Physical properties

Molecular weight570.78
SolventDMSO
Storage, safety and handling

H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
UNSPSC12352200
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Page updated on July 26, 2023