Diazepam azide

Product key features

Azide-functionalized for click chemistry – Enables selective conjugation via CuAAC or SPAAC, facilitating site-specific modification.
Pharmacologically active benzodiazepine core – Maintains high-affinity interaction with GABA_A receptors, suitable for receptor binding & modulation studies.
Broad probe compatibility – Reacts efficiently with alkyne-modified fluorophores, biotin, or drug delivery platforms for downstream applications.
Sterically accessible reactive site – Optimized structural design minimizes interference with conjugation efficiency & receptor binding.
Application versatility – Ideal for use in receptor localization, ligand-target engagement, mechanistic pharmacology & imaging-based assays.

Product description

Diazepam azide is an azide-functionalized analog of diazepam designed for site-specific conjugation using bioorthogonal click chemistry, including copper-catalyzed azide–alkyne cycloaddition (CuAAC) and strain-promoted azide–alkyne cycloaddition (SPAAC). The presence of the azide group allows for efficient and selective labeling while maintaining the pharmacologically active benzodiazepine scaffold that interacts with GABA_A receptors. This compound is well suited for applications in neuropharmacology and chemical biology, enabling covalent attachment to alkyne-containing fluorophores, affinity probes, or drug delivery systems. Diazepam azide supports real-time imaging, receptor binding studies, and mechanistic investigations by combining biological functionality with chemical reactivity. Its structural design minimizes steric hindrance around the reactive site, ensuring compatibility with conjugation strategies and retention of native receptor interactions. This reagent offers a flexible platform for exploring benzodiazepine receptor activity, visualizing ligand localization, and developing conjugate-based research tools.

References

View all 9 references: Citation Explorer

Impact of Benzodiazepine Delorazepam on Growth and Behaviour of Artemia salina Nauplii.
Authors: Fogliano, Chiara and Carotenuto, Rosa and Agnisola, Claudio and Motta, Chiara Maria and Avallone, Bice
Journal: Biology (2024)

Prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (Anguilla anguilla) from the Adour estuary (Basque Country, France).
Authors: Alvarez-Mora, Iker and Bolliet, Valérie and Lopez-Herguedas, Naroa and Castro, Lyen and Anakabe, Eneritz and Monperrus, Mathilde and Etxebarria, Nestor
Journal: Environmental pollution (Barking, Essex : 1987) (2022): 120016

An Experimental Study of Diazepam and Alprazolam Kinetics in Urine and Oral Fluid Following Single Oral Doses.
Authors: Temte, Vidar and Kjeldstadli, Kari and Bruun, Lina Dorthea and Birdal, Morris and Bachs, Liliana and Karinen, Ritva and Middelkoop, Gerrit and Øiestad, Elisabeth and Høiseth, Gudrun
Journal: Journal of analytical toxicology (2019): 104-111

Urinary diazepam metabolite distribution in a chronic pain population.
Authors: Luk, Samantha and Atayee, Rabia S and Ma, Joseph D and Best, Brookie M
Journal: Journal of analytical toxicology (2014): 135-42

In vitro diazepam metabolism in horses.
Authors: Hayami, Aki and Darwish, Wageh Sobhy and Ikenaka, Yoshinori and Nakayama, Shouta M M and Ishizuka, Mayumi
Journal: The Japanese journal of veterinary research (2013): S82-4

Page updated on June 27, 2025

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