Name: Diazepam azide
Brand: AAT Bioquest
SKU: 50662
Price: 989 USD
Availability: InStock

Diazepam azide

Diazepam azide is an azide-functionalized benzodiazepine that maintains pharmacological activity while enabling site-specific bioconjugation through click chemistry, useful for creating diazepam-based affinity probes and targeted delivery systems.

Azide-functionalized for click chemistry: Enables selective conjugation via CuAAC or SPAAC, facilitating site-specific modification
Sterically accessible reactive site: Optimized structural design minimizes interference with conjugation efficiency and receptor binding
Broad probe compatibility: Reacts efficiently with alkyne-modified fluorophores, biotin, or drug delivery platforms for downstream applications
Benzodiazepine activity preserved: Maintains GABAA receptor affinity for functional neuropharmacological studies

The chemical structure of Diazepam azide.

Datasheet

SDS

COA

Catalog	Size	Price	Quantity
50662	1 mg	Price

Overview

Diazepam azide is an azide-functionalized analog of diazepam designed for site-specific conjugation using bioorthogonal click chemistry, including copper-catalyzed azide–alkyne cycloaddition (CuAAC) and strain-promoted azide–alkyne cycloaddition (SPAAC). The presence of the azide group allows for efficient and selective labeling while maintaining the pharmacologically active benzodiazepine scaffold that interacts with GABAA receptors. This compound is well suited for applications in neuropharmacology and chemical biology, enabling covalent attachment to alkyne-containing fluorophores, affinity probes, or drug delivery systems. Diazepam azide supports real-time imaging, receptor binding studies, and mechanistic investigations by combining biological functionality with chemical reactivity. Its structural design minimizes steric hindrance around the reactive site, ensuring compatibility with conjugation strategies and retention of native receptor interactions. This reagent offers a flexible platform for exploring benzodiazepine receptor activity, visualizing ligand localization, and developing conjugate-based research tools.

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Diazepam azide to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	220.78 µL	1.104 mL	2.208 mL	11.039 mL	22.078 mL
5 mM	44.156 µL	220.78 µL	441.56 µL	2.208 mL	4.416 mL
10 mM	22.078 µL	110.39 µL	220.78 µL	1.104 mL	2.208 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	452.94 g/mol	=	mL	x	mM	=	mmol

References

View all 9 references: Citation Explorer

Impact of Benzodiazepine Delorazepam on Growth and Behaviour of Artemia salina Nauplii.

Authors:

Fogliano, Chiara and Carotenuto, Rosa and Agnisola, Claudio and Motta, Chiara Maria and Avallone, Bice

Journal:

Biology (2024)

Prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (Anguilla anguilla) from the Adour estuary (Basque Country, France).

Authors:

Alvarez-Mora, Iker and Bolliet, Valérie and Lopez-Herguedas, Naroa and Castro, Lyen and Anakabe, Eneritz and Monperrus, Mathilde and Etxebarria, Nestor

Journal:

Environmental pollution (Barking, Essex : 1987) (2022): 120016

An Experimental Study of Diazepam and Alprazolam Kinetics in Urine and Oral Fluid Following Single Oral Doses.

Authors:

Temte, Vidar and Kjeldstadli, Kari and Bruun, Lina Dorthea and Birdal, Morris and Bachs, Liliana and Karinen, Ritva and Middelkoop, Gerrit and Øiestad, Elisabeth and Høiseth, Gudrun

Journal:

Journal of analytical toxicology (2019): 104-111

Urinary diazepam metabolite distribution in a chronic pain population.

Authors:

Luk, Samantha and Atayee, Rabia S and Ma, Joseph D and Best, Brookie M

Journal:

Journal of analytical toxicology (2014): 135-42

In vitro diazepam metabolism in horses.

Authors:

Hayami, Aki and Darwish, Wageh Sobhy and Ikenaka, Yoshinori and Nakayama, Shouta M M and Ishizuka, Mayumi

Journal:

The Japanese journal of veterinary research (2013): S82-4

Physical properties

Molecular weight	452.94
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure

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Page updated on April 15, 2026