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Diazepam Biotin Conjugate
Product key features
- Biotin-functionalized diazepam analog designed for high-affinity interaction with streptavidin-based affinity systems.
- Maintains GABAA receptor binding integrity, preserving the pharmacophore of diazepam for target-specific studies.
- Facilitates affinity-based isolation and characterization of diazepam-interacting proteins from complex biological matrices.
- Enables sensitive and specific receptor-ligand interaction assays, including pull-downs, ELISAs, and biosensor platforms.
- Adaptable to high-throughput screening workflows for drug discovery and mechanistic studies involving GABAergic signaling.
Product description
Diazepam Biotin Conjugate is a structurally defined, biotinylated analog of diazepam engineered for affinity-based applications in neuropharmacological and biochemical research. The molecule features a stable covalent linkage between diazepam and biotin via a suitable spacer, designed to preserve the pharmacologically active benzodiazepine core while enabling high-affinity interaction with streptavidin, avidin, or neutravidin matrices. This dual functionality allows for the selective capture, enrichment, or immobilization of GABAA receptor subunits or diazepam-binding proteins in complex biological samples. The conjugate is particularly useful in receptor-ligand binding assays, affinity purification, and target deconvolution workflows, where it facilitates sensitive and specific interrogation of GABAergic signaling pathways. Its compatibility with biotin-binding platforms also supports its use in biosensor development and high-throughput screening for drug discovery.
References
View all 8 references: Citation Explorer
Acyl-CoA binding protein for the experimental treatment of anorexia.
Authors: Chen, Hui and Moriceau, Stéphanie and Joseph, Adrien and Mailliet, Francois and Li, Sijing and Tolle, Virginie and Duriez, Philibert and Dardennes, Roland and Durand, Sylvère and Carbonnier, Vincent and Stoll, Gautier and Sauvat, Allan and Lachkar, Sylvie and Aprahamian, Fanny and Alves Costa Silva, Carolina and Pan, Hui and Montégut, Léa and Anagnostopoulos, Gerasimos and Lambertucci, Flavia and Motiño, Omar and Nogueira-Recalde, Uxía and Bourgin, Mélanie and Mao, Misha and Pan, Yuhong and Cerone, Alexandra and Boedec, Erwan and Gouveia, Zelia L and Marmorino, Federica and Cremolini, Chiara and Derosa, Lisa and Zitvogel, Laurence and Kepp, Oliver and López-Otín, Carlos and Maiuri, Maria Chiara and Perez, Franck and Gorwood, Philip and Ramoz, Nicolas and Oury, Franck and Martins, Isabelle and Kroemer, Guido
Journal: Science translational medicine (2024): eadl0715
Authors: Chen, Hui and Moriceau, Stéphanie and Joseph, Adrien and Mailliet, Francois and Li, Sijing and Tolle, Virginie and Duriez, Philibert and Dardennes, Roland and Durand, Sylvère and Carbonnier, Vincent and Stoll, Gautier and Sauvat, Allan and Lachkar, Sylvie and Aprahamian, Fanny and Alves Costa Silva, Carolina and Pan, Hui and Montégut, Léa and Anagnostopoulos, Gerasimos and Lambertucci, Flavia and Motiño, Omar and Nogueira-Recalde, Uxía and Bourgin, Mélanie and Mao, Misha and Pan, Yuhong and Cerone, Alexandra and Boedec, Erwan and Gouveia, Zelia L and Marmorino, Federica and Cremolini, Chiara and Derosa, Lisa and Zitvogel, Laurence and Kepp, Oliver and López-Otín, Carlos and Maiuri, Maria Chiara and Perez, Franck and Gorwood, Philip and Ramoz, Nicolas and Oury, Franck and Martins, Isabelle and Kroemer, Guido
Journal: Science translational medicine (2024): eadl0715
Regulation of anxiety-like behaviors by S-palmitoylation and S-nitrosylation in basolateral amygdala.
Authors: Shen, Zu-Cheng and Liu, Jian-Min and Zheng, Jie-Yan and Li, Meng-Die and Tian, Dan and Pan, Yue and Tao, Wu-Cheng and Gao, Shuang-Qi and Xia, Zhi-Xuan
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2023): 115859
Authors: Shen, Zu-Cheng and Liu, Jian-Min and Zheng, Jie-Yan and Li, Meng-Die and Tian, Dan and Pan, Yue and Tao, Wu-Cheng and Gao, Shuang-Qi and Xia, Zhi-Xuan
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2023): 115859
Gephyrin Palmitoylation in Basolateral Amygdala Mediates the Anxiolytic Action of Benzodiazepine.
Authors: Shen, Zu-Cheng and Wu, Peng-Fei and Wang, Fang and Xia, Zhi-Xuan and Deng, Qiao and Nie, Tai-Lei and Zhang, Shao-Qi and Zheng, Hui-Ling and Liu, Wen-Hui and Lu, Jia-Jing and Gao, Shuang-Qi and Yao, Xia-Ping and Long, Li-Hong and Hu, Zhuang-Li and Chen, Jian-Guo
Journal: Biological psychiatry (2019): 202-213
Authors: Shen, Zu-Cheng and Wu, Peng-Fei and Wang, Fang and Xia, Zhi-Xuan and Deng, Qiao and Nie, Tai-Lei and Zhang, Shao-Qi and Zheng, Hui-Ling and Liu, Wen-Hui and Lu, Jia-Jing and Gao, Shuang-Qi and Yao, Xia-Ping and Long, Li-Hong and Hu, Zhuang-Li and Chen, Jian-Guo
Journal: Biological psychiatry (2019): 202-213
Excitatory tonus is required for the survival of granule cell precursors during postnatal development within the cerebellum.
Authors: Kanungo, A K and Liadis, N and Robertson, J and Woo, M and Henderson, J T
Journal: Neuroscience (2009): 1364-77
Authors: Kanungo, A K and Liadis, N and Robertson, J and Woo, M and Henderson, J T
Journal: Neuroscience (2009): 1364-77
Spatio-temporal profile of DNA fragmentation and its relationship to patterns of epileptiform activity following focally evoked limbic seizures.
Authors: Henshall, D C and Sinclair, J and Simon, R P
Journal: Brain research (2000): 290-302
Authors: Henshall, D C and Sinclair, J and Simon, R P
Journal: Brain research (2000): 290-302
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