Name: Diazepam KLH Conjugate
Brand: AAT Bioquest
SKU: 50666
Price: 989 USD
Availability: InStock

Diazepam KLH Conjugate

Diazepam KLH conjugate is a highly immunogenic conjugate linking diazepam to keyhole limpet hemocyanin carrier protein, optimized for antibody production against benzodiazepines in therapeutic drug monitoring applications.

Efficient Antibody Generation: Covalent linkage of diazepam to KLH promotes robust immunogenicity for the development of high-affinity polyclonal and monoclonal antibodies
Preservation of Epitope Integrity: Conjugation strategies maintain the native structural features of diazepam, ensuring selective and specific antibody responses
Assay Development Compatibility: Suitable for use in competitive ELISA, lateral flow assays, and other immunoanalytical methods targeting benzodiazepines
Research and Diagnostic Utility: Enables sensitive detection of diazepam in biological samples for pharmacokinetic, forensic, and clinical toxicology applications

The chemical structure of Diazepam KLH Conjugate.

Datasheet

SDS

COA

Catalog	Size	Price	Quantity
50666	1 mg	Price

Overview

Diazepam KLH conjugate consists of diazepam covalently linked to keyhole limpet hemocyanin (KLH), a high-molecular-weight, immunogenic carrier protein commonly used for hapten immunogen preparation. The conjugation is performed via established coupling chemistries that preserve the structural integrity of the diazepam moiety while maximizing epitope availability for immune recognition. This conjugate is specifically designed for the generation of anti-diazepam polyclonal and monoclonal antibodies, as well as for use in the development of competitive immunoassays. Diazepam, a benzodiazepine that acts as a positive allosteric modulator of GABAA receptors, is widely studied for its pharmacological effects, including anxiolytic, sedative, muscle relaxant, and anticonvulsant activities. The diazepam-KLH conjugate enables sensitive and specific detection of diazepam and related compounds in biological matrices. It is suitable for applications in pharmacokinetic studies, forensic toxicology, therapeutic drug monitoring, and the development of diagnostic assays.

References

View all 50 references: Citation Explorer

Neutralization of acyl CoA binding protein (ACBP) for the experimental treatment of osteoarthritis.

Authors:

Nogueira-Recalde, Uxía and Lambertucci, Flavia and Montégut, Léa and Motiño, Omar and Chen, Hui and Lachkar, Sylvie and Anagnostopoulos, Gerasimos and Stoll, Gautier and Li, Sijing and Carbonier, Vincent and Saavedra Díaz, Ester and Blanco, Francisco J and van Tetering, Geert and de Boer, Mark and Maiuri, Maria Chiara and Caramés, Beatriz and Martins, Isabelle and Kroemer, Guido

Journal:

Cell death and differentiation (2025)

Autophagy-dependent hepatocyte secretion of DBI/ACBP induced by glucocorticoids determines the pathogenesis of Cushing syndrome.

Authors:

Pan, Hui and Tian, Ai-Ling and Castinetti, Fréderic and Martins, Isabelle and Kepp, Oliver and Kroemer, Guido

Journal:

Autophagy (2025): 678-680

ACBP/DBI neutralization for the experimental treatment of fatty liver disease.

Authors:

Motiño, Omar and Lambertucci, Flavia and Joseph, Adrien and Durand, Sylvère and Anagnostopoulos, Gerasimos and Li, Sijing and Carbonnier, Vincent and Nogueira-Recalde, Uxía and Montégut, Léa and Chen, Hui and Aprahamian, Fanny and Nirmalathasan, Nitharsshini and Maiuri, Maria Chiara and Pietrocola, Federico and Valla, Dominique and Laouénan, Cédric and Gautier, Jean-François and Castera, Laurent and , and Martins, Isabelle and Kroemer, Guido

Journal:

Cell death and differentiation (2025): 434-446

Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance.

Authors:

Montégut, Léa and Liu, Peng and Zhao, Liwei and Pérez-Lanzón, María and Chen, Hui and Mao, Misha and Zhang, Shuai and Derosa, Lisa and Naour, Julie Le and Lambertucci, Flavia and Mingoia, Silvia and Nogueira-Recalde, Uxía and Mena-Osuna, Rafael and Herranz-Montoya, Irene and Djouder, Nabil and Baulande, Sylvain and Pan, Hui and Joseph, Adrien and Messaoudene, Meriem and Routy, Bertrand and Fidelle, Marine and Ben Ahmed, Tarek and Caron, Olivier and Busson, Pierre and Boulate, David and Deschasaux-Tanguy, Mélanie and Arnault, Nathalie and Pol, Jonathan G and Piaggio, Eliane and Touvier, Mathilde and Zitvogel, Laurence and Delaloge, Suzette and Martins, Isabelle and Kroemer, Guido

Journal:

Molecular cancer (2024): 187

Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing's syndrome.

Authors:

Pan, Hui and Tian, Ai-Ling and Chen, Hui and Xia, Yifan and Sauvat, Allan and Moriceau, Stephanie and Lambertucci, Flavia and Motiño, Omar and Zhao, Liwei and Liu, Peng and Mao, Misha and Li, Sijing and Zhang, Shuai and Joseph, Adrien and Durand, Sylvère and Aprahamian, Fanny and Luo, Zeyu and Ou, Yang and Shen, Zhe and Xue, Enfu and Pan, Yuhong and Carbonnier, Vincent and Stoll, Gautier and Forveille, Sabrina and Leduc, Marion and Cerrato, Giulia and Cerone, Alexandra and Maiuri, Maria Chiara and Castinetti, Frederic and Brue, Thierry and Wang, Hongsheng and Ma, Yuting and Martins, Isabelle and Kepp, Oliver and Kroemer, Guido

Journal:

Nature metabolism (2024): 2281-2299

Physical properties

Solvent

DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure

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Page updated on May 8, 2026