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DNP-PEG4 NHS ester

Compared to the commonly used DNP-X SE (#2021), DNP-PEG4 NHS ester has much better water solubility. It is an excellent amine-reactive building block for developing DNP probes that can be recognized by anti-DNP antibodies. It might be also used as an excellent amine-reactive FRET quencher paired with Trp or Tyr. Its terminal NHS ester group readily reacts with primary amines to form a stable amide bond. The hydrophilic PEG linker increases enable increasing number of DNP groups conjugated to a biological molecule without causing precipitation.

References

View all 50 references: Citation Explorer
Preventative and Therapeutic Effects of Low-dose Ionizing Radiation on the Allergic Response of Rat Basophilic Leukemia Cells.
Authors: Joo, Hae Mi and Hong, Eun Hee and Cho, Seong-Jun and Nam, Seon Young and Kim, Ji Young
Journal: Scientific reports (2019): 16079
Age-associated oxidative modifications of mitochondrial α-subunit of F1 ATP synthase from mouse skeletal muscles.
Authors: Das, N and Jana, C K
Journal: Free radical research (2015): 954-61
Rapid desensitization induces internalization of antigen-specific IgE on mouse mast cells.
Authors: Oka, Tatsuya and Rios, Eon J and Tsai, Mindy and Kalesnikoff, Janet and Galli, Stephen J
Journal: The Journal of allergy and clinical immunology (2013): 922-32.e1-16
IgG immune complex induces the recruitment of inflammatory cells into the airway and TNF-mediated late airway hyperresponsiveness via NF-κB activation in mice.
Authors: Lee, Chang-Hoon and Kim, Young-Suk and Kang, Nam-In and Lee, Young-Man and Kim, Kyoung-Jin and Chai, Ok-Hee and Song, Chang-Ho and Kim, Hae-Kyoung and Im, Suhn-Young and Oh, Dae-Kyu and Lee, Hern-Ku
Journal: The Journal of asthma : official journal of the Association for the Care of Asthma (2011): 757-66
Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease.
Authors: Moreira, Paula I and Sayre, Lawrence M and Zhu, Xiongwei and Nunomura, Akihiko and Smith, Mark A and Perry, George
Journal: Methods in molecular biology (Clifton, N.J.) (2010): 419-34
Page updated on November 12, 2024

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Catalog Number2023
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Physical properties

Molecular weight

528.47

Solvent

DMSO

Storage, safety and handling

H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22

Storage

Freeze (< -15 °C); Minimize light exposure
UNSPSC12171501

CAS

858126-78-0
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