Name: DSG [Di(N-succinimidyl) glutarate] *CAS 79642-50-5*
Brand: AAT Bioquest
SKU: 4520
Price: 90 USD
Availability: InStock

DSG

Di(N-succinimidyl) glutarate; CAS 79642-50-5

DSG is disuccinimidyl glutarate, a simple homobifunctional crosslinker based on the amine-reactive N-hydroxysuccinimide (NHS) ester group at both ends of a 5-atom (7.7 angstrom) spacer arm. It is used for crosslinking the molecules that have amine moiety. DSG is cell membrane-permeable. It is used in ChIP assays to determine DNA-protein binding interactions. DSG crosslinker must be dissolved in an organic solvent, such as DMSO or DMF, then added to an aqueous crosslinking reaction. Our in-house research demonstrated the DSG-crosslinked peptide conjugates have much better stability and tend to generate the antibodies of high specificity.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
4520	25 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of DSG [Di(N-succinimidyl) glutarate] *CAS 79642-50-5* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	306.504 µL	1.533 mL	3.065 mL	15.325 mL	30.65 mL
5 mM	61.301 µL	306.504 µL	613.008 µL	3.065 mL	6.13 mL
10 mM	30.65 µL	153.252 µL	306.504 µL	1.533 mL	3.065 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	326.26 g/mol	=	mL	x	mM	=	mmol

References

View all 25 references: Citation Explorer

Time-resolved FRET method for typing polymorphic alleles of the human leukocyte antigen system by using a single DNA probe

Authors:

Andreoni A, Bondani M, Nardo L.

Journal:

Photochem Photobiol Sci (2009): 1202

Tumor-specific detection of an optically targeted antibody combined with a quencher-conjugated neutravidin "quencher-chaser": a dual "quench and chase" strategy to improve target to nontarget ratios for molecular imaging of cancer

Authors:

Ogawa M, Kosaka N, Choyke PL, Kobayashi H.

Journal:

Bioconjug Chem (2009): 147

The detection of platelet derived growth factor using decoupling of quencher-oligonucleotide from aptamer/quantum dot bioconjugates

Authors:

Kim GI, Kim KW, Oh MK, Sung YM.

Journal:

Nanotechnology (2009): 175503

Development of a cell-based hepatitis C virus infection fluorescent resonance energy transfer assay for high-throughput antiviral compound screening

Authors:

Yu X, Sainz B, Jr., Uprichard SL.

Journal:

Antimicrob Agents Chemother (2009): 4311

An improved cell-penetrating, caspase-activatable, near-infrared fluorescent peptide for apoptosis imaging

Authors:

Maxwell D, Chang Q, Zhang X, Barnett EM, Piwnica-Worms D.

Journal:

Bioconjug Chem (2009): 702

Physical properties

Molecular weight	326.26
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C)
UNSPSC	12352200
CAS	79642-50-5

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Page updated on October 12, 2025