Name: EDTA Alkyne
Brand: AAT Bioquest
SKU: 65008
Price: 301 USD
Availability: InStock

EDTA Alkyne

EDTA alkyne is a click chemistry-enabled metal chelator that combines ethylenediaminetetraacetic acid with an alkyne group, allowing site-specific introduction of metal-binding capabilities into biomolecules via CuAAC reactions.

Click Chemistry Compatible: Alkyne group enables CuAAC reactions with azide-containing molecules
Metal Chelation Capacity: Retains full EDTA chelating ability for transition metal ions
Bioconjugation Versatility: Creates site-specific metal-binding probes for imaging and therapy
Mild Reaction Conditions: Compatible with sensitive biomolecules and physiological pH

Datasheet

SDS

COA

Catalog	Size	Price	Quantity
65008	5 mg	Price

Overview

EDTA alkyne is an excellent building block to develop site-specific ethylenediaminetetraacetic acid (EDTA) probes for variety of biomedical applications. It readily reacts with an azido compound (such as DBCO) under the well-known click chemistry conditions. EDTA is the most commonly used chelator for complexing transitional metal ions. EDTA chelation therapy uses the chelating agent, EDTA, to remove heavy metals and minerals from the body. It involves injecting EDTA into the bloodstream, where it binds to these substances, allowing them to be excreted through urine. EDTA is approved for treating lead poisoning, but it's also used in other conditions, including coronary artery disease and arthritis.

Calculators

Common stock solution preparation

Table 1. Volume of DMF needed to reconstitute specific mass of EDTA Alkyne to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	157.08 µL	785.398 µL	1.571 mL	7.854 mL	15.708 mL
5 mM	31.416 µL	157.08 µL	314.159 µL	1.571 mL	3.142 mL
10 mM	15.708 µL	78.54 µL	157.08 µL	785.398 µL	1.571 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	636.62 g/mol	=	mL	x	mM	=	mmol

References

View all 50 references: Citation Explorer

Two-in-one strategy to enhance the stability of Ti3C2Tx in transition metal ion solutions.

Authors:

Wang, Jie and Xie, Guanshun and Zhang, Senlin and Li, Guohao and Huang, Zhaohui and Li, Xiaohui and Xie, Xiuqiang and Zhang, Nan

Journal:

Journal of colloid and interface science (2025): 724-732

Use of confocal laser scanning microscopy to evaluate the metal ion removal and destabilization of Enterococcus faecalis biofilms by EDTA and etidronic acid.

Authors:

Tartari, Talita and Estrela, Carlos and de Araújo, Larissa Barbosa Borges and Graeff, Márcia Sirlene Zardin and de Andrade, Flaviana Bombarda and Duarte, Marco Antonio Hungaro

Journal:

Odontology (2025)

Highly efficient determination of metal ion in cosmetic samples by reversed-phase liquid-liquid microextraction based on green hydrophobic deep eutectic solvent.

Authors:

Liu, Bangfu and Zhou, Le-Zhou and He, Guo-Wen and Wang, Chaoli

Journal:

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry (2024): 115-121

Preparation of cellulose nanofiber/polyvinyl alcohol-based composite films for metal ion detection by starch/disodium calcium ethylenediaminetetraacetate synergistic complexation effect.

Authors:

Wang, Can and Shang, Yanlong and Guan, Jie and Chen, Nannan and Gao, Shan and Xu, Wenjing and Tao, Limin and Li, Zhimao and Shao, Ziqiang

Journal:

International journal of biological macromolecules (2024): 137265

Luminescent Silicon Nanocrystals as Metal Ion Sensors.

Authors:

Stacy, Benjamin J and Nagasaki, Kara and Korgel, Brian A

Journal:

ACS nano (2024): 15744-15753

Physical properties

Molecular weight	636.62
Solvent	DMF

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure

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Page updated on May 9, 2026