Name: EDTA Succinimidyl Ester
Brand: AAT Bioquest
SKU: 65005
Price: 199 USD
Availability: InStock

EDTA Succinimidyl Ester

EDTA succinimidyl ester is an amine-reactive chelating reagent that covalently attaches EDTA to lysine residues and N-termini, creating metal-binding bioconjugates for purification, detection, and therapeutic applications.

Amine-reactive NHS ester: Efficiently labels primary amines at pH 7–9 forming stable amide bonds
Broad Protein Compatibility: Conjugates to lysine residues and N-terminal amines
Metal Detection Capability: Creates chelating antibodies for heavy metal immunoassays
Therapeutic Applications: Develops targeted chelation therapy agents for metal toxicity

Datasheet

SDS

COA

Catalog	Size	Price	Quantity
65005	1 mg	Price

Overview

EDTA succinimidyl ester is an excellent building block to develop site-specific ethylenediaminetetraacetic acid (EDTA) probes for variety of biomedical applications. It readily reacts with an amino compound under extremely mild conditions. EDTA is the most commonly used chelator for complexing transitional metal ions. EDTA chelation therapy uses the chelating agent, EDTA, to remove heavy metals and minerals from the body. It involves injecting EDTA into the bloodstream, where it binds to these substances, allowing them to be excreted through urine. EDTA is approved for treating lead poisoning, but it's also used in other conditions, including coronary artery disease and arthritis.

Calculators

Common stock solution preparation

Table 1. Volume of DMF needed to reconstitute specific mass of EDTA Succinimidyl Ester to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	85.384 µL	426.92 µL	853.84 µL	4.269 mL	8.538 mL
5 mM	17.077 µL	85.384 µL	170.768 µL	853.84 µL	1.708 mL
10 mM	8.538 µL	42.692 µL	85.384 µL	426.92 µL	853.84 µL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	1171.18 g/mol	=	mL	x	mM	=	mmol

References

View all 11 references: Citation Explorer

Evaluating the Protective Effects of Melatonin Against Chronic Iron Administration in Male Wistar Rats: a Comparative Analysis of Affective, Cognitive, and Oxidative Stress with EDTA Chelator.

Authors:

Rezqaoui, Ayoub and Boumlah, Soufiane and El Hessni, Aboubaker and El Brouzi, Mohamed Yassine and El Hamzaoui, Abdelghafour and Ibouzine-Dine, Laila and Benkirane, Samir and Adnani, Manal and Mesfioui, Abdelhalem

Journal:

Biological trace element research (2024): 4531-4546

Looking for Novel Natural Gels to Improve Cleaning Methods for Bronze Leachates on Marble.

Authors:

Vázquez-de la Fuente, Iñaki and Barbier, Inés and Puente-Muñoz, Sara and Prieto-Taboada, Nagore and Arana, Gorka and Madariaga, Juan Manuel

Journal:

Gels (Basel, Switzerland) (2023)

Use of Parthenium hysterophorus with synthetic chelator for enhanced uptake of cadmium and lead from contaminated soils-a step toward better public health.

Authors:

Ejaz, Ujala and Khan, Shujaul Mulk and Aqeel, Muhammad and Khalid, Noreen and Sarfraz, Wajiha and Naeem, Nayab and Han, Heesup and Yu, Jongsik and Yue, Gong and Raposo, António

Journal:

Frontiers in public health (2022): 1009479

Doped Nanoscale NMC333 as Cathode Materials for Li-Ion Batteries.

Authors:

Hashem, Ahmed M and Abdel-Ghany, Ashraf E and Scheuermann, Marco and Indris, Sylvio and Ehrenberg, Helmut and Mauger, Alain and Julien, Christian M

Journal:

Materials (Basel, Switzerland) (2019)

Wood ash effects on growth and cadmium uptake in Deschampsia flexuosa (Wavy hair-grass).

Authors:

Kindtler, Nikolaj Lunding and Ekelund, Flemming and Rønn, Regin and Kjøller, Rasmus and Hovmand, Mads and Vestergård, Mette and Christensen, Søren and Johansen, Jesper Liengaard

Journal:

Environmental pollution (Barking, Essex : 1987) (2019): 886-893

Physical properties

Molecular weight	1171.18
Solvent	DMF

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure

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Page updated on April 3, 2026