EGTA AM *10 mM DMSO solution*

EGTA AM

10 mM DMSO solution

EGTA AM is cell-permeable version of EGTA (ethylene glycol tetraacetic acid), a cell-permeable calcium chelator. This EGTA derivative is used for adjusting calcium concentrations in cells and tissues. EGTA is an aminopolycarboxylic acid, a chelating agent. Compared to EDTA, EGTA has a lower affinity for magnesium, making it more selective for calcium ions. It is useful in buffer solutions that resemble the environment in living cells where calcium ions are usually at least a thousand fold less concentrated than magnesium. The pKa for binding of calcium ions by tetrabasic EGTA is 11.00, but the protonated forms do not significantly contribute to binding, so at pH 7, the apparent pKa becomes 6.91.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
21006	1 mL	Price

Citations

View all 4 citations: Citation Explorer

Dual ablation of the RyR2-Ser2808 and RyR2-Ser2814 sites increases propensity for pro-arrhythmic spontaneous Ca2+ releases

Authors:

Janicek, Radoslav and Camors, Emmanuel M and Potenza, Duilio M and Fernandez-Tenorio, Miguel and Zhao, Yanting and Dooge, Holly C and Loaiza, Randall and Alvarado, Francisco J and Egger, Marcel and Valdivia, Hector H and others,

Journal:

The Journal of Physiology (2024)

Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy

Authors:

Viswanathan, Meera C and Schmidt, William and Rynkiewicz, Michael J and Agarwal, Karuna and Gao, Jian and Katz, Joseph and Lehman, William and Cammarato, Anthony

Journal:

Cell Reports (2017): 2612--2625

Routes of Ca2+ shuttling during Ca2+ oscillations: Focus on the role of mitochondrial Ca2+ handling and cytosolic Ca2+ buffers

Authors:

Pecze, L{\'a}szl{\'o} and Blum, Walter and Schwaller, Beat

Journal:

Journal of Biological Chemistry (2015): 28214--28230

Routes of Ca2+ Shuttling during Ca2+ Oscillations FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS

Authors:

Pecze, László and Blum, Walter and Schwaller, Beat

Journal:

Journal of Biological Chemistry (2015): 28214--28230

References

View all 77 references: Citation Explorer

Tuning caged calcium: photolabile analogues of EGTA with improved optical and chelation properties

Authors:

Ellis-Davies GC, Barsotti RJ.

Journal:

Cell Calcium (2006): 75

Catalytic superoxide scavenging by metal complexes of the calcium chelator EGTA and contrast agent EHPG

Authors:

Fisher AE, Hague TA, Clarke CL, Naughton DP.

Journal:

Biochem Biophys Res Commun (2004): 163

Voltage-activated calcium signals in myotubes loaded with high concentrations of EGTA

Authors:

Schuhmeier RP, Dietze B, Ursu D, Lehmann-Horn F, Melzer W.

Journal:

Biophys J (2003): 1065

Role of calcium in nitric oxide-induced cytotoxicity: EGTA protects mouse oligodendrocytes

Authors:

Boullerne AI, Nedelkoska L, Benjamins JA.

Journal:

J Neurosci Res (2001): 124

L-type calcium channel blockers and EGTA enhance superoxide production in cardiac fibroblasts

Authors:

Shivakumar K, Kumaran C.

Journal:

J Mol Cell Cardiol (2001): 373

Physical properties

Molecular weight	668.6
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C)
UNSPSC	12352200
CAS	99590-86-0

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Page updated on September 30, 2025