Name: EGTA tetrasodium salt *CAS 13368-13-3*
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SKU: 21007
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EGTA tetrasodium salt

CAS 13368-13-3

EGTA (1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid) is a water-soluble and cell-impermeable calcium chelator. It has high selectivity to calcium. Compared to EDTA, EGTA has a lower affinity for magnesium, making it more selective for calcium ions. It is useful in buffer solutions that resemble the environment in living cells where calcium ions are usually at least a thousand fold less concentrated than magnesium. The pKa for binding of calcium ions by tetrabasic EGTA is 11.00, but the protonated forms do not significantly contribute to binding, so at pH 7, the apparent pKa becomes 6.91.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
21007	1 g	Price

Calculators

Common stock solution preparation

Table 1. Volume of Water needed to reconstitute specific mass of EGTA tetrasodium salt *CAS 13368-13-3* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	213.547 µL	1.068 mL	2.135 mL	10.677 mL	21.355 mL
5 mM	42.709 µL	213.547 µL	427.095 µL	2.135 mL	4.271 mL
10 mM	21.355 µL	106.774 µL	213.547 µL	1.068 mL	2.135 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	468.28 g/mol	=	mL	x	mM	=	mmol

Citations

View all 2 citations: Citation Explorer

Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy

Authors:

Viswanathan, Meera C and Schmidt, William and Rynkiewicz, Michael J and Agarwal, Karuna and Gao, Jian and Katz, Joseph and Lehman, William and Cammarato, Anthony

Journal:

Cell Reports (2017): 2612--2625

Routes of Ca2+ Shuttling during Ca2+ Oscillations FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS

Authors:

Pecze, László and Blum, Walter and Schwaller, Beat

Journal:

Journal of Biological Chemistry (2015): 28214--28230

References

View all 77 references: Citation Explorer

Tuning caged calcium: photolabile analogues of EGTA with improved optical and chelation properties

Authors:

Ellis-Davies GC, Barsotti RJ.

Journal:

Cell Calcium (2006): 75

Catalytic superoxide scavenging by metal complexes of the calcium chelator EGTA and contrast agent EHPG

Authors:

Fisher AE, Hague TA, Clarke CL, Naughton DP.

Journal:

Biochem Biophys Res Commun (2004): 163

Voltage-activated calcium signals in myotubes loaded with high concentrations of EGTA

Authors:

Schuhmeier RP, Dietze B, Ursu D, Lehmann-Horn F, Melzer W.

Journal:

Biophys J (2003): 1065

Gravicurvature loss, changes in ultrastructure and calcium balance of pea root statocytes treated with EGTA

Authors:

Belyavskaya NA., undefined

Journal:

J Gravit Physiol (2001): P33

L-type calcium channel blockers and EGTA enhance superoxide production in cardiac fibroblasts

Authors:

Shivakumar K, Kumaran C.

Journal:

J Mol Cell Cardiol (2001): 373

Physical properties

Molecular weight	468.28
Solvent	Water

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12352200
CAS	13368-13-3

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