Estradiol succinimidyl ester

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Physical properties

Molecular weight	456.50
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501

Alternative formats

Overview SDS Protocol

Molecular weight

456.50

Estradiol is an estrogen steroid hormone and the major female sex hormone. It is also called 17 beta-estradiol. Estradiol is involved in the regulation of the estrous and menstrual female reproductive cycles. It is responsible for the development of female secondary sexual characteristics and important in the development and maintenance of female reproductive tissues and pregnancy. It also has important effects in many other tissues including bone, fat, skin, liver, and the brain. Though estradiol levels in males are much lower compared to those in females, estradiol has important roles in males as well. An estradiol test measures the amount of the hormone estradiol in your blood. It is also called an E2 test. An estradiol test has a number of clinically important applications. Estradiol succinimidyl ester is a convenient building block for developing estradiol conjugates and assays.

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Estradiol succinimidyl ester to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	219.058 µL	1.095 mL	2.191 mL	10.953 mL	21.906 mL
5 mM	43.812 µL	219.058 µL	438.116 µL	2.191 mL	4.381 mL
10 mM	21.906 µL	109.529 µL	219.058 µL	1.095 mL	2.191 mL

Molarity calculator

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Images

Figure 1. Chemical structure for Estradiol succinimidyl ester.

References

View all 30 references: Citation Explorer

Efficient Synthesis of Glutamate Peptide-Estradiol Conjugate for Imaging Estrogen Receptor-Positive Diseases.
Authors: Shih, Ming-Chi and Simon, Sergio Daniel and Jin, Zhiming and Gui, Yuan and Xu, Bohua and Xu, Zhihong and Rosado-de-Castro, Paulo Henrique and Silveira Braghirolli, Ana Maria and Barbosa da Fonseca, Lea Mirian and Inoue, Tomio and Yang, David J
Journal: BioMed research international (2018): 5208964

A Gold(III) Pincer Ligand Scaffold for the Synthesis of Binuclear and Bioconjugated Complexes: Synthesis and Anticancer Potential.
Authors: Bertrand, Benoît and O'Connell, Maria A and Waller, Zoë A E and Bochmann, Manfred
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (2018): 3613-3622

Membrane-initiated estradiol signaling increases tyrosine hydroxylase promoter activity with ER alpha in PC12 cells.
Authors: Maharjan, Shreekrishna and Serova, Lidia I and Sabban, Esther L
Journal: Journal of neurochemistry (2010): 42-55

Bone selective effect of an estradiol conjugate with a novel tetracycline-derived bone-targeting agent.
Authors: Neale, Jason R and Richter, Natali B and Merten, Kevyn E and Taylor, K Grant and Singh, Sujan and Waite, Leonard C and Emery, Nicole K and Smith, Ned B and Cai, Jian and Pierce, William M
Journal: Bioorganic & medicinal chemistry letters (2009): 680-3

Picogram-detection of estradiol at an electrochemical immunosensor with a gold nanoparticle|Protein G-(LC-SPDP)-scaffold.
Authors: Liu, Xiaoqiang and Wong, Danny K Y
Journal: Talanta (2009): 1437-43

Estrogens exert a rapid apoptotic action in anterior pituitary cells.
Authors: Zárate, S and Jaita, G and Zaldivar, V and Radl, D B and Eijo, G and Ferraris, J and Pisera, D and Seilicovich, A
Journal: American journal of physiology. Endocrinology and metabolism (2009): E664-71

An estradiol-conjugate for radiolabelling with 177Lu: an attempt to prepare a radiotherapeutic agent.
Authors: Banerjee, Sharmila and Das, Tapas and Chakraborty, Sudipta and Samuel, Grace and Korde, Aruna and Venkatesh, Meera and Pillai, M R A
Journal: Bioorganic & medicinal chemistry (2005): 4315-22

Macromolecular prodrugs XI. Synthesis and characterization of polymer-estradiol conjugate.
Authors: Zovko, M and Zorc, B and Novak, P and Tepes, P and Cetina-Cizmek, B and Horvat, M
Journal: International journal of pharmaceutics (2004): 35-41

Engineering receptors and antibodies for biosensors.
Authors: Hock, B and Seifert, M and Kramer, K
Journal: Biosensors & bioelectronics (2002): 239-49

Some new aspects of 17alpha-estradiol metabolism in man.
Authors: Hobe, Gerhard and Schön, Renate and Goncharov, Nikolai and Katsiya, Gulnara and Koryakin, Mikhail and Gesson-Cholat, Isabelle and Oettel, Michael and Zimmermann, Holger
Journal: Steroids (2002): 883-93