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Fentanyl maleimide

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Physical properties
Molecular weight502.62
SolventDMSO
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
UNSPSC12171501
Alternative formats
Fentanyl succinimidyl ester

OverviewpdfSDSpdfProtocol


Molecular weight
502.62
Fentanyl maleimide can be conveniently used to make biological conjugates of fentanyl that are used to develop fentanyl assays and tests. It specifically reacts with thiols such as residue residue of proteins under slightly acidic conditions (pH 5.5-7.0).

Calculators


Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Fentanyl maleimide to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM198.957 µL994.787 µL1.99 mL9.948 mL19.896 mL
5 mM39.791 µL198.957 µL397.915 µL1.99 mL3.979 mL
10 mM19.896 µL99.479 µL198.957 µL994.787 µL1.99 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)Molecular weightVolume (Calculate)Concentration (Calculate)Moles
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References


View all 50 references: Citation Explorer
Nasal fentanyl alone plus buccal midazolam: an open-label, randomised, controlled feasibility study in the dying.
Authors: Perkins, Paul and Parkinson, Anne and Akyea, Ralph Kwame and Husbands, Emma
Journal: BMJ supportive & palliative care (2020)
Remifentanil and perioperative glycaemic response in cardiac surgery: an open-label randomised trial.
Authors: Subramaniam, Kathirvel and Sciortino, Christopher and Ruppert, Kristin and Monroe, Amy and Esper, Stephen and Boisen, Michael and Marquez, Jose and Hayanga, Heather and Badhwar, Vinay
Journal: British journal of anaesthesia (2020): 684-692
Low dose fentanyl infusion versus 24% oral sucrose for pain management during laser treatment for retinopathy of prematurity-an open label randomized clinical trial.
Authors: Sethi, Amanpreet and Sankar, M Jeeva and Kulkarni, Srikanth and Thukral, Anu and Chandra, Parijat and Agarwal, Ramesh
Journal: European journal of pediatrics (2020): 285-292
Continuous regional arterial infusion versus intravenous administration of the protease inhibitor nafamostat mesilate for predicted severe acute pancreatitis: a multicenter, randomized, open-label, phase 2 trial.
Authors: Hirota, Morihisa and Shimosegawa, Tooru and Kitamura, Katsuya and Takeda, Kazunori and Takeyama, Yoshifumi and Mayumi, Toshihiko and Ito, Tetsuhide and Takenaka, Mamoru and Iwasaki, Eisuke and Sawano, Hirotaka and Ishida, Etsuji and Miura, Shin and Masamune, Atsushi and Nakai, Yousuke and Mitoro, Akira and Maguchi, Hiroyuki and Kimura, Kenji and Sanuki, Tsuyoshi and Ito, Tetsuya and Haradome, Hiroki and Kozaka, Kazuto and Gabata, Toshifumi and Kataoka, Keisho and Hirota, Masahiko and Isaji, Shuji and Nakamura, Ryoji and Yamagiwa, Koki and Kayaba, Chie and Ikeda, Koji
Journal: Journal of gastroenterology (2020): 342-352
Raman mapping of fentanyl transdermal delivery systems with off-label modifications.
Authors: Xu, Teng and Yilmaz, Huzeyfe and Willett, Daniel R and Strasinger, Caroline and Rodriguez, Jason D and Keire, David A and Wokovich, Anna M
Journal: The Analyst (2020): 953-962
Off-label use of prescription analgesics among hospitalized children in the United States.
Authors: Carmack, Mary and Berde, Charles and Monuteaux, Michael C and Manzi, Shannon and Bourgeois, Florence T
Journal: Pharmacoepidemiology and drug safety (2020): 474-481
OFF-LABEL AND UNLICENSED DRUGS IN PEDIATRIC PALLIATIVE CARE: A PROSPECTIVE OBSERVATIONAL STUDY.
Authors: García-López, Isabel and Cuervas-Mons Vendrell, Margarita and Romero, Irene Martin and de Noriega, Iñigo and González, Juana Benedí and Martino-Alba, Ricardo
Journal: Journal of pain and symptom management (2020)
Cross-sectional survey of off-label and unlicensed prescribing for inpatients at a paediatric teaching hospital in Western Australia.
Authors: Landwehr, Caitlin and Richardson, Jennifer and Bint, Lewis and Parsons, Richard and Sunderland, Bruce and Czarniak, Petra
Journal: PloS one (2019): e0210237
Continuous infusion versus intermittent bolus doses of fentanyl for analgesia and sedation in neonates: an open-label randomised controlled trial.
Authors: Abiramalatha, Thangaraj and Mathew, Sumith Koshy and Mathew, Binu Susan and Shabeer, Machilakath Panangandi and Arulappan, Geethanjali and Kumar, Manish and Jayaseelan, Visalakshi and Kuruvilla, Kurien Anil
Journal: Archives of disease in childhood. Fetal and neonatal edition (2019): F433-F439
Effect of intrathecal morphine and epidural analgesia on postoperative recovery after abdominal surgery for gynecologic malignancy: an open-label randomised trial.
Authors: Kjølhede, Preben and Bergdahl, Olga and Borendal Wodlin, Ninnie and Nilsson, Lena
Journal: BMJ open (2019): e024484