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Fentanyl succinimidyl ester

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InternationalSee distributors
ShippingStandard overnight for United States, inquire for international
Physical properties
Molecular weight477.56
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
Alternative formats
Fentanyl maleimide


Molecular weight
Fentanyl succinmidyl ester can be conveniently used to make biological conjugates of fentanyl that are used to develop fentanyl assays and tests. It specifically reacts with aliphatic amines such as lysine residue of proteins under slightly basic conditions (pH 7.5-9.5).


Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Fentanyl succinimidyl ester to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM209.398 µL1.047 mL2.094 mL10.47 mL20.94 mL
5 mM41.88 µL209.398 µL418.796 µL2.094 mL4.188 mL
10 mM20.94 µL104.699 µL209.398 µL1.047 mL2.094 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

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View all 9 references: Citation Explorer
A fentanyl vaccine constructed upon opsonizing antibodies specific for the Galα1-3Gal epitope.
Authors: Wang, Jiaxing and Ellis, Beverly and Zhou, Bin and Eubanks, Lisa M and Blake, Steven and Janda, Kim D
Journal: Chemical communications (Cambridge, England) (2020): 6551-6554
[Study of the Metabolism of New Drugs of Abuse].
Authors: Kanamori, Tatsuyuki
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan (2019): 699-704
A chemically contiguous hapten approach for a heroin-fentanyl vaccine.
Authors: Natori, Yoshihiro and Hwang, Candy S and Lin, Lucy and Smith, Lauren C and Zhou, Bin and Janda, Kim D
Journal: Beilstein journal of organic chemistry (2019): 1020-1031
Use of hepatocytes isolated from a liver-humanized mouse for studies on the metabolism of drugs: application to the metabolism of fentanyl and acetylfentanyl.
Authors: Kanamori, Tatsuyuki and Togawa-Iwata, Yuko and Segawa, Hiroki and Yamamuro, Tadashi and Kuwayama, Kenji and Tsujikawa, Kenji and Inoue, Hiroyuki
Journal: Forensic toxicology (2018): 467-475
In Vitro and In Vivo Metabolite Identification Studies for the New Synthetic Opioids Acetylfentanyl, Acrylfentanyl, Furanylfentanyl, and 4-Fluoro-Isobutyrylfentanyl.
Authors: Watanabe, Shimpei and Vikingsson, Svante and Roman, Markus and Green, Henrik and Kronstrand, Robert and Wohlfarth, Ariane
Journal: The AAPS journal (2017): 1102-1122
Fentanyl-related 4-heteroanilido piperidine OHM3295 augments splenic natural killer activity and induces analgesia through opioid receptor pathways.
Authors: Baker, M L and Brockunier, L L and Bagley, J R and France, C P and Carr, D J
Journal: The Journal of pharmacology and experimental therapeutics (1995): 1285-92
Gamma-scintigraphy and early hepatocellular dysfunction during posttraumatic sepsis.
Authors: McGinty, M P and Stewart, R M and Fabian, M J and Fabian, T C and Proctor, K G
Journal: Surgery (1994): 535-43
Alfentanil pharmacokinetics and metabolism in humans.
Authors: Meuldermans, W and Van Peer, A and Hendrickx, J and Woestenborghs, R and Lauwers, W and Heykants, J and Vanden Bussche, G and Van Craeyvelt, H and Van der Aa, P
Journal: Anesthesiology (1988): 527-34
Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing painful orthognathic surgery.
Authors: Muraoka, Wataru and Nishizawa, Daisuke and Fukuda, Kenichi and Kasai, Shinya and Hasegawa, Junko and Wajima, Koichi and Nakagawa, Taneaki and Ikeda, Kazutaka
Journal: Molecular pain : 1744806916683182