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FerroBrite™ Green

Ferroptosis is an iron-dependent form of regulated cell death associated with the increase in lipid peroxides. Divalent iron (Fe2+) can lead to spontaneous lipid peroxidation through the Fenton reaction. Ferroptosis is regulated by signaling pathways that control iron storage and oxidative stress. FerroBrite™ Green has been developed for detecting ferroptosis via fluorescence imaging. FerroBrite™ Green has superior photostability and responds quickly to ferroptosis. The dye is permeable to live cells. Upon induction of ferroptosis, the imbalance of Fe2+ causes the reduction in the fluorescence intensity of FerroBrite™ Green. The fluorescence of FerroBrite™ Green can be readily monitored using the common FITC filter, which is equipped in most of fluorescence instruments. FerroBrite™ Green enables the real-time tracking of ferroptosis.

Erastin induced ferroptosis in Hela cells. The fluorescence response of FerroBrite™ Green (20 µM) was evaluated in HeLa cells, in the absence and presence of 6-hour Erastin treatment at 37°C, 5% CO2 incubator. Fluorescence intensities were measured using fluorescence microscopy equipped with a FITC filter.
Erastin induced ferroptosis in Hela cells. The fluorescence response of FerroBrite™ Green (20 µM) was evaluated in HeLa cells, in the absence and presence of 6-hour Erastin treatment at 37°C, 5% CO2 incubator. Fluorescence intensities were measured using fluorescence microscopy equipped with a FITC filter.
CatalogSize
Price
Quantity
202051 mg
Price
 
Physical properties

Molecular weight352.45
SolventDMSO
Spectral properties

Excitation (nm)453
Emission (nm)552
Storage, safety and handling

Certificate of OriginDownload PDF
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
Instrument settings

Fluorescence microscope
Excitation450 nm
Emission550 nm
Recommended plateBlack wall/clear bottom
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Page updated on October 16, 2025