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FITC–dextran conjugate (average MW = ~150K)

FITC-labeled dextran is used in cardiovascular, microcirculation, perfusion, cell monolayer and cell membrane permeability research as fluorescent flux tracer compound that supports the measurement of processes such as blood flow, membrane damage, vascular drainage and renal elimination. It is also used in microcirculation and cell permeability research utilizing microfluorimetry, and possible in perfusion studies in animals. FITC-dextran has also been used to study plant cell wall porosity and capillary permeability. Plasma proteins have been shown not to bind to FITC-dextran. Fluorescein-dextran of150 kDa may be used to help assess the integrity of the blood brain barrier (BBB) and to perform fluorescence microlymphography. It may also be used as a microcirculation vascular flux tracer.

Spectrum

Product family

NameExcitation (nm)Emission (nm)Extinction coefficient (cm -1 M -1)Quantum yieldCorrection Factor (280 nm)
FITC–dextran conjugate (average MW = ~20K)491516730000.920.35
FITC–dextran conjugate (average MW = ~70K)491516730000.920.35
TRITC–dextran conjugate (average MW = ~150K)544570100000-0.34

Citations

View all 44 citations: Citation Explorer
Vitexin Suppresses High-Glucose-upregulated Adhesion Molecule Expression in Endothelial Cells through Inhibiting NF-$\kappa$B Signaling Pathway
Authors: Chen, Pie-Che and Chang, Yun-Ching and Tsai, Kun-Ling and Shen, Cheng Huang and Lee, Shin-Da
Journal: ACS Omega (2024)
Lymphatic Reconnection and Restoration of Lymphatic Flow by Nonvascularized Lymph Node Transplantation: Real-Time Fluorescence Imaging Using Indocyanine Green and Fluorescein Isothiocyanate-Dextran
Authors: Maeda, T., Yamamoto, Y., Iwasaki, D., Hayashi, T., Funayama, E., Oyama, A., Murao, N., Furukawa, H.
Journal: Lymphat Res Biol (2018): 165-173
Optimizing Fluorescein Isothiocyanate Dextran Measurement As a Biomarker in a 24-h Feed Restriction Model to Induce Gut Permeability in Broiler Chickens
Authors: Baxter, M. F. A., Merino-Guzman, R., Latorre, J. D., Mahaffey, B. D., Yang, Y., Teague, K. D., Graham, L. E., Wolfenden, A. D., Hern and ez-Velasco, X., Bielke, L. R., Hargis, B. M., Tellez, G.
Journal: Front Vet Sci (2017): 56
Fluorescein Isothiocyanate (FITC)-Dextran Extravasation as a Measure of Blood-Brain Barrier Permeability
Authors: Natarajan, R., Northrop, N., Yamamoto, B.
Journal: Curr Protoc Neurosci (2017): 9 58 1-9 58 15
Adenosine receptor agonist NECA increases cerebral extravasation of fluorescein and low molecular weight dextran independent of blood-brain barrier modulation
Authors: Cheng, C. C., Yang, Y. L., Liao, K. H., Lai, T. W.
Journal: Sci Rep (2016): 23882
Page updated on November 9, 2024

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Catalog Number21704
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Physical properties

Molecular weight

~150000

Solvent

Water

Spectral properties

Correction Factor (280 nm)

0.35

Extinction coefficient (cm -1 M -1)

73000

Excitation (nm)

491

Emission (nm)

516

Quantum yield

0.92

Storage, safety and handling

H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22

Storage

Freeze (< -15 °C); Minimize light exposure
UNSPSC12171501
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