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FMOC-Statine [FMOC-Sta(3S,4S)-OH] *CAS 158257-40-0*
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Additional ordering information
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| Shipping | Standard overnight for United States, inquire for international |
Physical properties
| Molecular weight | 397.47 |
| Solvent | DMF |
Storage, safety and handling
| H-phrase | H303, H313, H333 |
| Hazard symbol | XN |
| Intended use | Research Use Only (RUO) |
| R-phrase | R20, R21, R22 |
| Storage | Freeze (< -15 °C) |
| UNSPSC | 12352200 |
| Overview |  SDSProtocol |
CAS 158257-40-0 | Molecular weight 397.47 |
(3S,4S)-Statine is a novel amino acid of pepstatin, a low molecular weight inhibitor of acid proteases. This FMOC-Statine building lock is a very useful precursor for preparing protease-resistant peptide for pharmacetical application using the standard FMOC chemistry.
Calculators
Common stock solution preparation
Table 1. Volume of DMF needed to reconstitute specific mass of FMOC-Statine [FMOC-Sta(3S,4S)-OH] *CAS 158257-40-0* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 251.591 µL | 1.258 mL | 2.516 mL | 12.58 mL | 25.159 mL |
| 5 mM | 50.318 µL | 251.591 µL | 503.183 µL | 2.516 mL | 5.032 mL |
| 10 mM | 25.159 µL | 125.796 µL | 251.591 µL | 1.258 mL | 2.516 mL |
Molarity calculator
Enter any two values (mass, volume, concentration) to calculate the third.
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Images
Figure 1. Chemical structure for FMOC-Statine [FMOC-Sta(3S,4S)-OH] *CAS 158257-40-0*
References
View all 54 references: Citation Explorer
Drug (statine)-induced hepatitis
Authors: Lazebnik LB, Zvenigorodskaia LA, Khomeriki SG, Efremov LI, Cherkashova EA.
Journal: Eksp Klin Gastroenterol (2009): 110
Authors: Lazebnik LB, Zvenigorodskaia LA, Khomeriki SG, Efremov LI, Cherkashova EA.
Journal: Eksp Klin Gastroenterol (2009): 110
Investigation of the synthetic route to pepstatin analogues by SPPS using O-protected and O-unprotected statine as building blocks
Authors: Cadicamo CD, Asante V, Abu Ammar M, Borelli C, Korting HC, Koksch B.
Journal: J Pept Sci (2009): 272
Authors: Cadicamo CD, Asante V, Abu Ammar M, Borelli C, Korting HC, Koksch B.
Journal: J Pept Sci (2009): 272
Atovaquone-statine "double-drugs" with high antiplasmodial activity
Authors: Romeo S, Parapini S, Dell'Agli M, Vaiana N, Magrone P, Galli G, Sparatore A, Taramelli D, Bosisio E.
Journal: ChemMedChem (2008): 418
Authors: Romeo S, Parapini S, Dell'Agli M, Vaiana N, Magrone P, Galli G, Sparatore A, Taramelli D, Bosisio E.
Journal: ChemMedChem (2008): 418
A simple microscale method for determining the relative stereochemistry of statine units
Authors: Preciado A, Williams PG.
Journal: J Org Chem (2008): 9228
Authors: Preciado A, Williams PG.
Journal: J Org Chem (2008): 9228
Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: exploration of P1 phenoxy and benzyloxy residues
Authors: Back M, Nyhlen J, Kvarnstrom I, Appelgren S, Borkakoti N, Jansson K, Lindberg J, Nystrom S, Hallberg A, Rosenquist S, Samuelsson B.
Journal: Bioorg Med Chem (2008): 9471
Authors: Back M, Nyhlen J, Kvarnstrom I, Appelgren S, Borkakoti N, Jansson K, Lindberg J, Nystrom S, Hallberg A, Rosenquist S, Samuelsson B.
Journal: Bioorg Med Chem (2008): 9471
Stereocontrolled synthesis of 2,4-diamino-3-hydroxyacids starting from diketopiperazines: a new route for the preparation of statine analogues
Authors: Farran D, Toupet L, Martinez J, Dewynter G.
Journal: Org Lett (2007): 4833
Authors: Farran D, Toupet L, Martinez J, Dewynter G.
Journal: Org Lett (2007): 4833
Macrocyclic statine-based inhibitors of BACE-1
Authors: Barazza A, Gotz M, Cadamuro SA, Goettig P, Willem M, Steuber H, Kohler T, Jestel A, Reinemer P, Renner C, Bode W, Moroder L.
Journal: Chembiochem (2007): 2078
Authors: Barazza A, Gotz M, Cadamuro SA, Goettig P, Willem M, Steuber H, Kohler T, Jestel A, Reinemer P, Renner C, Bode W, Moroder L.
Journal: Chembiochem (2007): 2078
A novel approach to identifying beta-secretase inhibitors: bis-statine peptide mimetics discovered using structure and spot synthesis
Authors: Bridges KG, Chopra R, Lin L, Svenson K, Tam A, Jin G, Cowling R, Lovering F, Akopian TN, DiBlasio-Smith E, Annis-Freeman B, Marvell TH, LaVallie ER, Zollner RS, Bard J, Somers WS, Stahl ML, Kriz RW.
Journal: Peptides (2006): 1877
Authors: Bridges KG, Chopra R, Lin L, Svenson K, Tam A, Jin G, Cowling R, Lovering F, Akopian TN, DiBlasio-Smith E, Annis-Freeman B, Marvell TH, LaVallie ER, Zollner RS, Bard J, Somers WS, Stahl ML, Kriz RW.
Journal: Peptides (2006): 1877
Molecular docking and 3D-QSAR studies on the binding mechanism of statine-based peptidomimetics with beta-secretase
Authors: Zuo Z, Luo X, Zhu W, Shen J, Shen X, Jiang H, Chen K.
Journal: Bioorg Med Chem (2005): 2121
Authors: Zuo Z, Luo X, Zhu W, Shen J, Shen X, Jiang H, Chen K.
Journal: Bioorg Med Chem (2005): 2121
Plasmepsin II inhibition and antiplasmodial activity of Primaquine-Statine 'double-drugs'
Authors: Romeo S, Dell'Agli M, Parapini S, Rizzi L, Galli G, Mondani M, Sparatore A, Taramelli D, Bosisio E.
Journal: Bioorg Med Chem Lett (2004): 2931
Authors: Romeo S, Dell'Agli M, Parapini S, Rizzi L, Galli G, Mondani M, Sparatore A, Taramelli D, Bosisio E.
Journal: Bioorg Med Chem Lett (2004): 2931