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ICG-TFP ester
Ordering information
| Price | |
| Catalog Number | |
| Unit Size | |
| Quantity |
Additional ordering information
| Telephone | 1-800-990-8053 |
| Fax | 1-800-609-2943 |
| sales@aatbio.com | |
| International | See distributors |
| Bulk request | Inquire |
| Custom size | Inquire |
| Shipping | Standard overnight for United States, inquire for international |
Physical properties
| Molecular weight | 981.06 |
| Solvent | DMSO |
Storage, safety and handling
| H-phrase | H303, H313, H333 |
| Hazard symbol | XN |
| Intended use | Research Use Only (RUO) |
| R-phrase | R20, R21, R22 |
| Storage | Freeze (< -15 °C); Minimize light exposure |
| UNSPSC | 12171501 |
| Overview |  SDSProtocol |
See also: Indocyanine Green
Molecular weight 981.06 |
Indocyanine green (ICG) is a cyanine dye used in medical diagnostics. It is used for determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography. It has a peak spectral absorption close to 800 nm. These infrared frequencies penetrate retinal layers, allowing ICG angiography to image deeper patterns of circulation than fluorescein angiography. The amino-reactive ICG-Sulfo-OSu (#180) is predominantly used to make various ICG bioconjugates with antibodies and other biological molecules since it has improved water solubility compared to other ICG amine-reactive derivatives. However, the well-known ICG-Sulfo-OSu is extremely unstable. ICG-TFP ester has significantly improved stability and good water solubility. Under the same conditions, it gives higher conjugation yield than ICG-Sulfo-OSu.
Calculators
Common stock solution preparation
Table 1. Volume of DMSO needed to reconstitute specific mass of ICG-TFP ester to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 101.931 µL | 509.653 µL | 1.019 mL | 5.097 mL | 10.193 mL |
| 5 mM | 20.386 µL | 101.931 µL | 203.861 µL | 1.019 mL | 2.039 mL |
| 10 mM | 10.193 µL | 50.965 µL | 101.931 µL | 509.653 µL | 1.019 mL |
Molarity calculator
Enter any two values (mass, volume, concentration) to calculate the third.
| Mass (Calculate) | Molecular weight | Volume (Calculate) | Concentration (Calculate) | Moles | ||||
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Images
Figure 1. Chemical structure for ICG-TFP ester.
Citations
View all 5 citations: Citation Explorer
In vivo photoacoustic imaging of cancer using indocyanine green-labeled monoclonal antibody targeting the epidermal growth factor receptor
Authors: Sano, K., Ohashi, M., Kanazaki, K., Ding, N., Deguchi, J., Kanada, Y., Ono, M., Saji, H.
Journal: Biochem Biophys Res Commun (2015): 820-5
Authors: Sano, K., Ohashi, M., Kanazaki, K., Ding, N., Deguchi, J., Kanada, Y., Ono, M., Saji, H.
Journal: Biochem Biophys Res Commun (2015): 820-5
In vitro and in vivo analysis of indocyanine green-labeled panitumumab for optical imaging-a cautionary tale
Authors: Zhou, Y., Kim, Y. S., Milenic, D. E., Baidoo, K. E., Brechbiel, M. W.
Journal: Bioconjug Chem (2014): 1801-10
Authors: Zhou, Y., Kim, Y. S., Milenic, D. E., Baidoo, K. E., Brechbiel, M. W.
Journal: Bioconjug Chem (2014): 1801-10
Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes
Authors: Sano, K., Nakajima, T., Miyazaki, K., Ohuchi, Y., Ikegami, T., Choyke, P. L., Kobayashi, H.
Journal: Bioconjug Chem (2013): 811-6
Authors: Sano, K., Nakajima, T., Miyazaki, K., Ohuchi, Y., Ikegami, T., Choyke, P. L., Kobayashi, H.
Journal: Bioconjug Chem (2013): 811-6
Dual-modality imaging with 99mTc and fluorescent indocyanine green using surface-modified silica nanoparticles for biopsy of the sentinel lymph node: an animal study
Authors: Tsuchimochi, M., Hayama, K., Toyama, M., Sasagawa, I., Tsubokawa, N.
Journal: EJNMMI Res (2013): 33
Authors: Tsuchimochi, M., Hayama, K., Toyama, M., Sasagawa, I., Tsubokawa, N.
Journal: EJNMMI Res (2013): 33
Activatable fluorescent cys-diabody conjugated with indocyanine green derivative: consideration of fluorescent catabolite kinetics on molecular imaging
Authors: Sano, K., Nakajima, T., Ali, T., Bartlett, D. W., Wu, A. M., Kim, I., Paik, C. H., Choyke, P. L., Kobayashi, H.
Journal: J Biomed Opt (2013): 101304
Authors: Sano, K., Nakajima, T., Ali, T., Bartlett, D. W., Wu, A. M., Kim, I., Paik, C. H., Choyke, P. L., Kobayashi, H.
Journal: J Biomed Opt (2013): 101304
Application notes
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