ICG-TFP ester

Indocyanine green (ICG) is a cyanine dye used in medical diagnostics. It is used for determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography. It has a peak spectral absorption close to 800 nm. These infrared frequencies penetrate retinal layers, allowing ICG angiography to image deeper patterns of circulation than fluorescein angiography. The amino-reactive ICG-Sulfo-OSu (#180) is predominantly used to make various ICG bioconjugates with antibodies and other biological molecules since it has improved water solubility compared to other ICG amine-reactive derivatives. However, the well-known ICG-Sulfo-OSu is extremely unstable. ICG-TFP ester has significantly improved stability and good water solubility. Under the same conditions, it gives higher conjugation yield than ICG-Sulfo-OSu.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
990	1 mg	Price

Citations

View all 5 citations: Citation Explorer

In vivo photoacoustic imaging of cancer using indocyanine green-labeled monoclonal antibody targeting the epidermal growth factor receptor

Authors:

Sano, K., Ohashi, M., Kanazaki, K., Ding, N., Deguchi, J., Kanada, Y., Ono, M., Saji, H.

Journal:

Biochem Biophys Res Commun (2015): 820-5

In vitro and in vivo analysis of indocyanine green-labeled panitumumab for optical imaging-a cautionary tale

Authors:

Zhou, Y., Kim, Y. S., Milenic, D. E., Baidoo, K. E., Brechbiel, M. W.

Journal:

Bioconjug Chem (2014): 1801-10

Activatable fluorescent cys-diabody conjugated with indocyanine green derivative: consideration of fluorescent catabolite kinetics on molecular imaging

Authors:

Sano, K., Nakajima, T., Ali, T., Bartlett, D. W., Wu, A. M., Kim, I., Paik, C. H., Choyke, P. L., Kobayashi, H.

Journal:

J Biomed Opt (2013): 101304

Dual-modality imaging with 99mTc and fluorescent indocyanine green using surface-modified silica nanoparticles for biopsy of the sentinel lymph node: an animal study

Authors:

Tsuchimochi, M., Hayama, K., Toyama, M., Sasagawa, I., Tsubokawa, N.

Journal:

EJNMMI Res (2013): 33

Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes

Authors:

Sano, K., Nakajima, T., Miyazaki, K., Ohuchi, Y., Ikegami, T., Choyke, P. L., Kobayashi, H.

Journal:

Bioconjug Chem (2013): 811-6

Physical properties

Molecular weight	981.06
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501

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Page updated on October 15, 2025