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iFluor® 790 Alkyne

iFluor® 790 Alkyne readily reacts with biomolecules that contain an azido group. It can be conveniently used to develop NIR imaging probers. Our iFluor® 790 dye is designed to label proteins and other biomolecules with near infrared fluorescence. Conjugates prepared with iFluor® 790 have the excitation and emission spectra similar to that of indocyanine green (ICG) and the IRDye® 800 dye, with 783/814 nm excitation/emission maxima. iFluor® 790 dye emission is well separated from commonly used far-red fluorophores such as Cy5, Cy7 or allophycocyanin (APC), facilitating multicolor analysis. This fluorophore is extremely useful for small animal in-vivo imaging applications or for other imaging applications that require NIR detections such as the two-color western applications with the LI-COR® Odyssey® infrared imaging system. In vivo fluorescence imaging uses a sensitive camera to detect fluorescence emission from fluorophores in whole-body living small animals. To overcome the photon attenuation in living tissue, fluorophores with long emission at the near-infrared (NIR) region are generally preferred, including widely used small indocarbocyanine dyes. Recent advances in imaging strategies and reporter techniques for in vivo fluorescence imaging include novel approaches to improve the specificity and affinity of the probes and to modulate and amplify the signal at target sites for enhanced sensitivity. Further emerging developments are aiming to achieve high-resolution, multimodality and lifetime-based in vivo fluorescence imaging.

Spectrum

Product family

NameExcitation (nm)Emission (nm)Extinction coefficient (cm -1 M -1)Quantum yieldCorrection Factor (260 nm)Correction Factor (280 nm)
iFluor® 647 alkyne65667025000010.2510.030.03
iFluor® 555 alkyne55757010000010.6410.230.14
iFluor® 488 alkyne4915167500010.910.210.11
iFluor® 790 Styramide *Superior Replacement for Alexa Fluor 790 tyramide*78781225000010.1310.10.09

References

View all 50 references: Citation Explorer
CD64 as novel molecular imaging marker for the characterization of synovitis in rheumatoid arthritis.
Authors: Theeuwes, Wessel F and Di Ceglie, Irene and Dorst, Daphne N and Blom, Arjen B and Bos, Desiree L and Vogl, Thomas and Tas, Sander W and Jimenez-Royo, Pilar and Bergstrom, Mats and Cleveland, Matthew and van der Kraan, Peter M and Laverman, Peter and Koenders, Marije I and van Lent, Peter L and van den Bosch, Martijn H J
Journal: Arthritis research & therapy (2023): 158
In vivo quantification of programmed death-ligand-1 expression heterogeneity in tumors using fluorescence lifetime imaging.
Authors: Pal, Rahul and K, Murali and Matsui, Aya and Kang, Homan and Morita, Satoru and Taniguchi, Hajime and Kobayashi, Tatsuya and Morita, Atsuyo and Choi, Hak Soo and Duda, Dan G and Kumar, Anand T N
Journal: Research square (2023)
Near-Infrared Fluorescence Imaging in Preclinical Models of Glioblastoma.
Authors: Llaguno-Munive, Monserrat and Villalba-Abascal, Wilberto and Avilés-Salas, Alejandro and Garcia-Lopez, Patricia
Journal: Journal of imaging (2023)
Preclinical evaluation of EpCAM-binding designed ankyrin repeat proteins (DARPins) as targeting moieties for bimodal near-infrared fluorescence and photoacoustic imaging of cancer.
Authors: Houvast, Ruben D and Badr, Nada and March, Taryn and de Muynck, Lysanne D A N and Sier, Vincent Q and Schomann, Timo and Bhairosingh, Shadhvi and Baart, Victor M and Peeters, Judith A H M and van Westen, Gerard J P and Plückthun, Andreas and Burggraaf, Jacobus and Kuppen, Peter J K and Vahrmeijer, Alexander L and Sier, Cornelis F M
Journal: European journal of nuclear medicine and molecular imaging (2023)
NIRDye 812: A molecular platform tailored for multimodal bioimaging applications of targeted fluorescence- and photoacoustic-guided surgery.
Authors: Hettie, Kenneth S and Chin, Frederick T
Journal: Journal of photochemistry and photobiology. B, Biology (2023): 112683
Page updated on October 11, 2024

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Catalog Number1365
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Physical properties

Molecular weight

1316.35

Solvent

Water

Spectral properties

Correction Factor (260 nm)

0.1

Correction Factor (280 nm)

0.09

Extinction coefficient (cm -1 M -1)

2500001

Excitation (nm)

787

Emission (nm)

812

Quantum yield

0.131

Storage, safety and handling

H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22

Storage

Freeze (< -15 °C); Minimize light exposure
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