Name: IP1 Alkyne
Brand: AAT Bioquest
SKU: 20343
Price: 469 USD
Availability: InStock

IP1 Alkyne

IP1 alkyne is a click chemistry-enabled inositol monophosphate building block that reacts with azide-containing molecules to create probes for detecting IP1 and studying inositol phosphate signaling pathways.

Click Chemistry Ready: Terminal alkyne enables CuAAC reactions with azido compounds
IP1 Detection Probes: Creates specific sensors for myo-inositol 1-phosphate quantification
GPCR Signaling Studies: Monitors IP1 accumulation as a readout for Gq-coupled receptor activity
Bioorthogonal Conjugation: Compatible with live-cell and in vitro labeling applications

Datasheet

SDS

COA

Catalog	Size	Price	Quantity
20343	100 ug	Price

Overview

IP1 Alkyne is an excellent building block to develop probes for detecting 1D-myo-inositol 1-phosphate (IP1) via the well-known click chemistry (CuAAC). It readily reacts with azido-containing biomolecules (such as peptides, antibodies and azido-modified oligos) under extremely mild conditions. IP1 is an inositol having myo- configuration substituted at position 1 by a phosphate group. It has a role as a human metabolite, an Escherichia coli metabolite and a mouse metabolite. IP1 is functionally related to myo-inositol. It is a conjugate acid of 1D-myo-inositol 1-phosphate.

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of IP1 Alkyne to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	281.5 µL	1.407 mL	2.815 mL	14.075 mL	28.15 mL
5 mM	56.3 µL	281.5 µL	563 µL	2.815 mL	5.63 mL
10 mM	28.15 µL	140.75 µL	281.5 µL	1.407 mL	2.815 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	355.24 g/mol	=	mL	x	mM	=	mmol

References

View all 49 references: Citation Explorer

SCA44- and SCAR13-associated GRM1 mutations affect metabotropic glutamate receptor 1 function through distinct mechanisms.

Authors:

Wang, Yuyang and Muraleetharan, Ashwin and Langiu, Monica and Gregory, Karen J and Hellyer, Shane D

Journal:

British journal of pharmacology (2024)

Direct Stimulatory Effects of the CB2 Ligand JTE 907 in Human and Mouse Islets.

Authors:

Ruz-Maldonado, Inmaculada and Atanes, Patricio and Huang, Guo Cai and Liu, Bo and Persaud, Shanta J

Journal:

Cells (2021)

Tacrine-xanomeline and tacrine-iperoxo hybrid ligands: Synthesis and biological evaluation at acetylcholinesterase and M1 muscarinic acetylcholine receptors.

Authors:

Maspero, Marco and Volpato, Daniela and Cirillo, Davide and Yuan Chen, Natalia and Messerer, Regina and Sotriffer, Christoph and De Amici, Marco and Holzgrabe, Ulrike and Dallanoce, Clelia

Journal:

Bioorganic chemistry (2020): 103633

Isolation of rat hepatocytes for pharmacological studies on metabotropic glutamate receptor (mGluR) subtype 5: a comparison between collagenase I versus collagenase IV.

Authors:

Berardo, Clarissa and Ferrigno, Andrea and Siciliano, Veronica and Richelmi, Plinio and Vairetti, Mariapia and Di Pasqua, Laura Giuseppina

Journal:

European journal of histochemistry : EJH (2020)

Potency, efficacy, and selectivity of GR64349 at human recombinant neurokinin NK2 and NK1 receptors.

Authors:

Perdona, Elisabetta and Cavallini, Palmina and Sava, Anna and Griffante, Cristiana and Ricca, Daniel J and Thor, Karl B and Rupniak, Nadia M J and Corsi, Mauro

Journal:

Neuroscience letters (2019): 134456

Physical properties

Molecular weight	355.24
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure

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Page updated on May 5, 2026