Name: IP1 Maleimide
Brand: AAT Bioquest
SKU: 20341
Price: 459 USD
Availability: InStock

IP1 Maleimide

IP1 maleimide is a thiol-reactive inositol monophosphate building block that selectively conjugates to cysteine residues for developing site-specific IP1 probes and studying inositol signaling cascades.

Thiol-Selective Conjugation: Maleimide rapidly reacts with free cysteines at pH 6.5–7.5
Site-Specific Labeling: Targets reduced cysteine residues in proteins and peptides
Stable Thioether Bond: Forms irreversible conjugates under physiological conditions
IP1 Sensor Development: Creates targeted probes for monitoring inositol phosphate signaling

Protocol

SDS

COA

Catalog	Size	Price	Quantity
20341	100 ug	Price

Overview

IP1 Maleimide is an excellent building block to develop probes for detecting 1D-myo-inositol 1-phosphate (IP1). It readily reacts with thiol-containing biomolecules (such as peptides, antibodies and thiol-modified oligos) under extremely mild conditions. IP1 is an inositol having myo- configuration substituted at position 1 by a phosphate group. It has a role as a human metabolite, an Escherichia coli metabolite and a mouse metabolite. IP1 is functionally related to myo-inositol. It is a conjugate acid of 1D-myo-inositol 1-phosphate.

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of IP1 Maleimide to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	220.109 µL	1.101 mL	2.201 mL	11.005 mL	22.011 mL
5 mM	44.022 µL	220.109 µL	440.218 µL	2.201 mL	4.402 mL
10 mM	22.011 µL	110.055 µL	220.109 µL	1.101 mL	2.201 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	454.32 g/mol	=	mL	x	mM	=	mmol

References

View all 50 references: Citation Explorer

A new look at angiogenesis inhibition of geniposide in experimental arthritis by blocking angiopoietin-2 exocytosis.

Authors:

Gan, Peirong and Wu, Hong and Zhu, Yulong and Shu, Yin and Wei, Yi

Journal:

Phytotherapy research : PTR (2024): 1245-1261

SCA44- and SCAR13-associated GRM1 mutations affect metabotropic glutamate receptor 1 function through distinct mechanisms.

Authors:

Wang, Yuyang and Muraleetharan, Ashwin and Langiu, Monica and Gregory, Karen J and Hellyer, Shane D

Journal:

British journal of pharmacology (2024)

Non-inositol 1,4,5-trisphosphate (IP3) receptor IP3-binding proteins.

Authors:

Mackrill, John James

Journal:

Biochimica et biophysica acta. Molecular cell research (2023): 119470

The pair ceramide 1-phosphate/ceramide kinase regulates intracellular calcium and progesterone-induced human sperm acrosomal exocytosis.

Authors:

Vaquer, Cintia C and Suhaiman, Laila and Pavarotti, Martín A and Arias, Rodolfo J and Pacheco Guiñazú, Anahí B and De Blas, Gerardo A and Belmonte, Silvia A

Journal:

Frontiers in cell and developmental biology (2023): 1148831

A mutation in Arabidopsis SAL1 alters its in vitro activity against IP3 and delays developmental leaf senescence in association with lower ROS levels.

Authors:

Shirzadian-Khorramabad, Reza and Moazzenzadeh, Taghi and Sajedi, Reza H and Jing, Hai-Chun and Hille, Jacques and Dijkwel, Paul P

Journal:

Plant molecular biology (2022): 549-563

Physical properties

Molecular weight	454.32
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure

Documents

Protocol
Safety Data Sheet
Certificate of Analysis

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Page updated on December 15, 2025