Name: Maleimide Activated cBSA *Optimized for Maximum Immunization Response*
Brand: AAT Bioquest
SKU: 5608
Price: 412 USD
Availability: InStock

Maleimide Activated cBSA

Optimized for Maximum Immunization Response

Maleimide Activated cBSA facilitates the conjugation of sulfhydryl-containing peptide antigens to immunogenic bovine serum albumin (BSA) carrier proteins for immunization and antibody production. The purified, carrier-grade BSA is rendered sulfhydryl-reactive through chemical modification with a Sulfo-SMCC crosslinker, resulting in a maleimide-activated protein capable of forming covalent crosslinks with sulfhydryl (-SH) groups on cysteine residues of peptides and other thiol-containing haptens. This process allows the conjugation of multiple antigen molecules to each cBSA molecule, enhancing their immunogenicity and increasing the likelihood of eliciting high-titer antisera to the desired epitopes in immunized animals. As an immunogen, cationized BSA (cBSA) induces a significantly higher antibody response compared to native BSA. cBSA is produced by substituting the anionic carboxyl groups of native BSA with cationic aminoethyl-amide groups, thereby markedly enhancing its immunogenic properties. cBSA is effective in conjugation with both haptens and proteins, amplifying the immunological response to the conjugated molecule. This method eliminates the need for developing specific protocols for each antigen system, generating a stronger anti-peptide response than traditional carriers and enhancing the antibody response to proteins with low isoelectric points.

General packaging for Cat. No. 5608. Your actual packaging may differ.

Datasheet

SDS

COA

Catalog	Size	Price	Quantity
5608	5 x 1 mg	Price

References

View all 50 references: Citation Explorer

Unfolding Protein-Based Hapten Coupling via Thiol-Maleimide Click Chemistry: Enhanced Immunogenicity in Anti-Nicotine Vaccines Based on a Novel Conjugation Method and MPL/QS-21 Adjuvants.

Authors:

Xu, Ying and Li, Huiting and Meng, Xiongyan and Yang, Jing and Xue, Yannan and Teng, Changcai and Lv, Wenxin and Wang, Zhen and Li, Xiaodan and Sun, Tiantian and Meng, Shuai and Zong, Chengli

Journal:

Polymers (2024)

Enhancing Photothermal/Photodynamic Therapy for Glioblastoma by Tumor Hypoxia Alleviation and Heat Shock Protein Inhibition Using IR820-Conjugated Reduced Graphene Oxide Quantum Dots.

Authors:

Dash, Banendu Sunder and Lu, Yu-Jen and Chen, Jyh-Ping

Journal:

ACS applied materials & interfaces (2024): 13543-13562

Big is not better: Comparing two alpha-Gal-bearing glycotopes in neoglycoproteins as biomarkers for Leishmania (Viannia) braziliensis infection.

Authors:

Montoya, Alba L and Gil, Eileni R and Vinales, Irodiel and Estevao, Igor L and Taboada, Paola and Torrico, Mary Cruz and Torrico, Faustino and Marco, Jorge Diego and Almeida, Igor C and Michael, Katja

Journal:

Carbohydrate research (2024): 109015

Barrier-penetrating liposome targeted delivery of basic fibroblast growth factor for spinal cord injury repair.

Authors:

Wu, Fenzan and Wang, Penghui and Wei, Xiaojie and Yang, Yanhong and Al Mamun, Abdullah and Zhang, Xie and Zhu, Yunsen and Mo, Tingting and Zhang, Hongyu and Jiang, Chang and Hu, Jie and Xiao, Jian

Journal:

Materials today. Bio (2023): 100546

Naphthalene Diimide-Based Orange Emitting Luminogen: A Fluorometric Probe for Thiol Sensing through the Click Reaction.

Authors:

Roy, Kathakoli and Ghosh, Anup Kumar and Das, Prasanta Kumar

Journal:

Langmuir : the ACS journal of surfaces and colloids (2023): 15690-15704

Physical properties

Solvent

Water

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C)
UNSPSC	12171501

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Page updated on May 5, 2026