Maleimide Activated cOVA *Optimized for Maximum Immunization Response*

Maleimide Activated cOVA

Optimized for Maximum Immunization Response

Maleimide Activated cOVA is a sulfhydryl-reactive form specifically designed for efficient hapten-carrier conjugation with cysteine-containing peptides and other thiolated antigens. This product consists of purified cationized ovalbumin (cOVA) that has been modified with an SMCC crosslinker to introduce maleimide groups. These groups facilitate the formation of stable covalent bonds with sulfhydryl groups on cysteine residues, enabling precise conjugation and the attachment of multiple antigens per carrier molecule without epitope interference. Cationized Ovalbumin (cOVA) is synthesized by treating native ovalbumin with ethylenediamine, which replaces the majority of negatively charged carboxyl groups with positively charged primary amines. This modification results in a highly positively charged cOVA, significantly enhancing the immunogenicity of the ovalbumin. Additionally, the increase in primary amines provides more conjugation sites for hapten molecules, thus enhancing the versatility of standard conjugation techniques. Despite being more hydrophobic and less soluble in aqueous buffers than Bovine Serum Albumin (BSA), cOVA maintains solubility in up to 70% DMSO. This characteristic makes it particularly useful for conjugation with haptens that require DMSO for solubility.

General packaging for Cat. No. 5610. Your actual packaging may differ.

Datasheet

SDS

COA

Catalog	Size	Price	Quantity
5610	5 x 1 mg	Price

References

View all 30 references: Citation Explorer

Sustained intra-cartilage delivery of interleukin-1 receptor antagonist using cationic peptide and protein-based carriers.

Authors:

Mehta, S and Boyer, T L and Akhtar, S and He, T and Zhang, C and Vedadghavami, A and Bajpayee, A G

Journal:

Osteoarthritis and cartilage (2023): 780-792

Preparation of Peptide and Recombinant Tissue Plasminogen Activator Conjugated Poly(Lactic-Co-Glycolic Acid) (PLGA) Magnetic Nanoparticles for Dual Targeted Thrombolytic Therapy.

Authors:

Chen, Huai-An and Ma, Yunn-Hwa and Hsu, Tzu-Yuan and Chen, Jyh-Ping

Journal:

International journal of molecular sciences (2020)

A versatile platform for surface modification of microfluidic droplets.

Authors:

Li, Mingqiang and Jiang, Weiqian and Chen, Zaozao and Suryaprakash, Smruthi and Lv, Shixian and Tang, Zhaohui and Chen, Xuesi and Leong, Kam W

Journal:

Lab on a chip (2017): 635-639

Optimizing ultrasound molecular imaging of secreted frizzled related protein 2 expression in angiosarcoma.

Authors:

Tsuruta, James K and Schaub, Nicholas P and Rojas, Juan D and Streeter, Jason and Klauber-DeMore, Nancy and Dayton, Paul

Journal:

PloS one (2017): e0174281

Iminoboronates are efficient intermediates for selective, rapid and reversible N-terminal cysteine functionalisation.

Authors:

Faustino, Hélio and Silva, Maria J S A and Veiros, Luís F and Bernardes, Gonçalo J L and Gois, Pedro M P

Journal:

Chemical science (2016): 5052-5058

Physical properties

Solvent

Water

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C)
UNSPSC	12171501

Telephone
Fax
Email	sales@aatbio.com
International	See distributors
Bulk request	Inquire
Custom size	Inquire
Technical Support	Contact us
Request quotation	Request
Purchase order	Send to sales@aatbio.com
Shipping	Standard overnight for United States, inquire for international

Page updated on May 6, 2026